A5078300510- Chemical Synthesis and Analysis
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Mesoporous Materials and Catalysis
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Antimicrobial Peptides and Activities
- Catalytic C–H Functionalization Methods
- Metal complexes synthesis and properties
- Catalytic Cross-Coupling Reactions
- Pharmacological Effects and Toxicity Studies
- Neuroendocrine regulation and behavior
- Pharmacological Receptor Mechanisms and Effects
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Catalytic Processes in Materials Science
- Biochemical and Structural Characterization
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Fungal Infections and Studies
- Inorganic and Organometallic Chemistry
- Epilepsy research and treatment
- Neurotransmitter Receptor Influence on Behavior
Iowa State University
2022-2024
National Institute of Pharmaceutical Education and Research
2012-2023
Chitkara University
2023
The Ohio State University
2020-2022
University of Kansas
2018-2019
National Institute of Pharmaceutical Education and Research
2014-2017
Eternal Hospital
2015
Sharda University
2013-2014
University College of Medical Sciences
2005-2014
Institute of Medical Sciences
2013
Hard graft pays off for Henry: An efficient acid–base bifunctional mesoporous catalyst was prepared by one-step post-synthesis grafting of aminoorganoalkoxysilane groups on silica (see picture). The led to yields over 99 % in the Henry reaction (nitroaldol condensation) p-hydroxybenzaldehyde and nitromethane form nitrostyrene.
We report that the polarity and dielectric constants of solvents used for grafting organosilanes on mesoporous materials strongly affect concentration grafted organic groups, degree their site-isolation, catalytic properties resulting materials. Polar nonpolar as well polar-protic, dipolar-aprotic, were investigated. Polar-protic solvents, which have high constants, resulted in smaller concentrations ( approximately 1-2 mmol/g) polar groups such 3-aminopropyl higher surface area materials,...
We studied the effect of two types mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) isolated mitochondria. SBA-15 inhibited cellular respiration at 25–500 µg/mL; inhibition was concentration-dependent time-dependent. The ATP profile paralleled that respiration. had no noticeable rate. In cells depleted metabolic fuels, 50 µg/mL delayed onset glucose-supported by 12 min 200 34 min; also Neither nor...
Gold (Au) catalysts have been rarely investigated for the oxidation of glucose in absence a base. These conditions are critical, however, to enable sequential one-pot combination cellulose hydrolysis and glucoseoxidation. Here we evaluate catalytic performance stability Au nanoparticles supported on metal oxides gluconic acid under unadjusted pH acidic conditions. The study provides insights into deactivation caused by leaching hydrothermal sintering nanoparticles, as well adsorption...
Abstract We report a solution‐phase synthetic route to copper nanoparticles with controllable size and shape. The synthesis of the is achieved by reduction copper(II) salt in aqueous solution hydrazine under air atmosphere presence poly(acrylic acid) (PAA) as capping agent. results suggest that pH plays key role for formation pure nanoparticles, whereas concentration PAA important controlling geometric shape nanoparticles. average can be varied from 30 80 nm, depending on PAA. With moderate...
We report on the effects of surface density and spacing between grafted organoamines (and residual ungrafted silanols) amine-functionalized mesoporous materials their (cooperative) catalytic activity in Henry reaction. The bifunctional groups (amines silanols), site isolation, were controlled by one-step or two-step grafting a series organosilanes containing linear alkylamine, alkyldiamine, alkyltriamine, meta- para-substituted aromatic amines onto silica ethanol and/or toluene. produced...
The present study was performed to examine the effect of Eugenia caryophyllata (Myrtaceae) on learning and memory, also evaluate whether it can modulate oxidative stress in mice. Passive avoidance step-down task elevated plus-maze were used assess memory scopolamine-treated Oxidative parameters assessed brain samples by estimating malondialdehyde (MDA) reduced glutathione (GSH) levels at end study. Scopolamine (0.3 mg/kg, i. p.) produced impairment acquisition as evidenced a decrease latency...
Abstract Contemporary research indicates promising anticonvulsant effect of curcumin. However, its poor oral bioavailability is a major hindrance toward pharmacological action. Thus, this study was carried out to evaluate the acute liposome‐entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)‐induced seizures, and status epilepticus in mice. Liposome‐entrapped doses 25 50 mg/kg demonstrated significant increase seizure threshold latency...
Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported.
Imidazolones represent an important class of heterocycles present in a wide range pharmaceuticals, metabolites, and bioactive natural products serve as the active chromophore green fluorescent protein. Recently, imidazolones have received attention for their ability to act nonaromatic amide bond bioisotere which improves pharmacological properties. Herein, we tandem amidine installation cyclization with adjacent ester yield (4