A5050529121- MicroRNA in disease regulation
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Developmental Biology and Gene Regulation
- Food Security and Health in Diverse Populations
- Fibroblast Growth Factor Research
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Trypanosoma species research and implications
- Genetic factors in colorectal cancer
- Insect Pest Control Strategies
- Genomics and Chromatin Dynamics
- Obesity, Physical Activity, Diet
- Research on Leishmaniasis Studies
- Nutritional Studies and Diet
- Multiple Myeloma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Circular RNAs in diseases
Stanford University
2020-2024
Massachusetts Institute of Technology
2012-2017
The University of Texas MD Anderson Cancer Center
2012-2014
Allen Institute
2012
Koch Institute for Integrative Cancer Research At MIT
2012
The Lundquist Institute
2011
Harbor–UCLA Medical Center
2011
Dicer is an RNase III family endoribonuclease and haploinsufficient tumor suppressor that processes mature miRNAs from the 5′ (5p) or 3′ (3p) arm of hairpin precursors. In murine knockout fibroblasts, we expressed human with point mutations in III, helicase, PAZ domains characterized miRNA expression by Northern blot massively parallel sequencing small RNAs. We report inactivation IIIA domain results complete loss 3p-derived miRNAs, but only partial reduction 5p-derived miRNAs. Conversely,...
Significance The mammalian central nervous system contains unique projections from the cerebral cortex thought to underpin complex motor and cognitive skills, including corticospinal tract corpus callosum. neurons giving rise these projections—corticospinal callosal projection neurons—develop same progenitors, but acquire strikingly different fates. broad evolutionary conservation of known genes controlling cortical neuron fates raises question how more narrowly conserved evolved. We...
Background TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk cancers. In this study, we investigated associations between potentially functional SNPs 3′UTR gastric cancer US population. Methods We conducted case-control study 301 patients 313 cancer-free controls frequency-matched by age, sex ethnicity. genotyped four selected (rs8126 T>C, rs710100 G>A, rs1052912 G>A...
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression critical for organismal viability. Changes in miRNA activity common cancer, but how these changes relate to subsequent alterations transcription and the process tumorigenesis is not well understood. Here, we report a deep transcriptional, oncogenic network regulated by miRNAs. We present analysis phenotypic associated with global restoration miRNA-deficient fibroblasts. This uncovers miRNA-repressed containing...
Host defense peptides are naturally occurring molecules that play essential roles in innate immunity to infection. Based on prior structure-function knowledge, we tested two synthetic (RP-1 and AA-RP-1) modeled the conserved, microbicidal α-helical domain of mammalian CXCL4 platelet kinocidins. These were evaluated for efficacy against Leishmania species, causative agents group diseases known as leishmaniasis. In vitro antileishmanial activity was assessed three distinct strains by measuring...
CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) may modulate its gene functions thus cancer risk patient survival. We hypothesized that potentially SNPs are associated with gastric (GC) To test this hypothesis, we conducted a case-control study 371 GC patients 313 cancer-free controls frequency-matched by age, sex, ethnicity. genotyped four selected, (rs2240688A>C, rs7686732C>G, rs10022537T>A, rs3130C>T) used logistic regression...
Abstract The corticospinal tract is unique to mammals and the corpus callosum placental (eutherians). emergence of these structures thought underpin evolutionary acquisition complex motor cognitive skills. Corticospinal neurons (CSMN) callosal projection (CPN) are archetypal callosum, respectively. Although a number conserved transcriptional regulators CSMN CPN development have been identified in vertebrates, none most co-expressed across multiple neuron subtypes. Here, we discover seventeen...
MicroRNAs (miRNAs) are post‐transcriptional regulators that fine‐tune gene expression. Despite the modest 2‐fold repression miRNA activity generally confers on a target, miRNAs critical for many biological processes. By regulating core transcription factors and their downstream effectors, modify transcriptional networks. However, description of interactions between networks has been limited, magnitude these not investigated. We sought to investigate programs regulated by in adult murine...
Abstract In the cerebral cortex, cortical projection neurons comprise classes of project to distant regions central nervous system. These develop from same progenitor pool, but they acquire strikingly different inputs and outputs underpin functions. The question how corticospinal - involved in motor function implicated paralysis callosal cognitive autism represents a fundamental clinically important neurodevelopment. A network transcription factors, including selector gene Fezf2, is...