A5069622917- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Ovarian cancer diagnosis and treatment
- Cultural Differences and Values
- Digital Imaging for Blood Diseases
- Acute Myeloid Leukemia Research
- Advanced Breast Cancer Therapies
- Psychology of Moral and Emotional Judgment
- Radiomics and Machine Learning in Medical Imaging
- Gynecological conditions and treatments
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Gut microbiota and health
- Management of metastatic bone disease
- vaccines and immunoinformatics approaches
- DNA Repair Mechanisms
- Hair Growth and Disorders
- Clostridium difficile and Clostridium perfringens research
Addgene
2022-2024
University of Minnesota
2020-2023
Bipar
2023
University of Minnesota Medical Center
2019-2022
Novartis (United States)
2022
University of Michigan
2018-2022
Precision for Medicine (United States)
2022
The University of Texas Health Science Center at Houston
2018-2020
University of Colorado Denver
2020
Roswell Park Comprehensive Cancer Center
2016
Abstract Background Homologous recombination deficiency (HRD) is a phenotype that characterized by the inability of cell to effectively repair DNA double-strand breaks using homologous (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, which target destruction cancer cells working concert with HRD through synthetic lethality. However, identify patients these...
The lack of comprehensive diagnostics and consensus analytical models for evaluating the status a patient's immune system has hindered wider adoption immunoprofiling treatment monitoring response prediction in cancer patients. To address this unmet need, we developed an platform that uses multiparameter flow cytometry to characterize cell heterogeneity peripheral blood healthy donors patients with advanced cancers. Using unsupervised clustering, identified five immunotypes unique...
Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create PDA mouse model and show that neoantigen expression required for intratumoral T cell accumulation response immune checkpoint blockade. By generating peptide:MHC tetramer, we identify induces rapid intratumoral, progressive systemic, tumor-specific exhaustion. Monotherapy PD-1 or PD-L1 blockade enhances systemic expansion objective responses require cells. However, tumor escape variants defective...
Recent studies have shown promising results in using Deep Learning to detect malignancy whole slide imaging, however, they were limited just predicting a positive or negative finding for specific neoplasm. We attempted use with convolutional neural network (CNN) algorithm build lymphoma diagnostic model four categories: (1) benign lymph node, (2) diffuse large B-cell lymphoma, (3) Burkitt and (4) small lymphocytic lymphoma. Our software was written Python language. obtained digital...
Abstract Pancreatic cancer is a particularly lethal malignancy that resists immunotherapy. In this study, using preclinical pancreatic murine model, we demonstrate progressive decrease in IFN-γ and granzyme B concomitant increase Tox IL-10 intratumoral tumor-specific T cells. Intratumoral myeloid cells produced elevated IL-27, cytokine correlates with poor patient outcome. Abrogating IL-27 signaling significantly decreased Tox+ delayed tumor growth yet was not curative. Agonistic αCD40...
The gastrointestinal tract represents one of the largest body surfaces that is exposed to outside world. It only mucosal surface required simultaneously recognize and defend against pathogens, while allowing nutrients containing foreign antigens be tolerated absorbed. differentiates between these substances through a complex system pattern recognition receptors expressed on intestinal epithelial cells as well underlying immune cells. These actively sample evaluate microbes other particles...
Silicone injections have been used for cosmetic soft tissue augmentation over five decades with documented consequences both systemic and dermatologic. We present a case of extensive filler migration causing bilateral lower extremity woody induration in 53 year old Hispanic woman. She presented multi-year history progressive joint stiffening at the knees, accompanied by pain extremities. The patient had received two an unknown substance placed into her gluteals 11 years prior. MRI indicated...
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells differentiate are maintained in vivo could inform novel therapeutic avenues promote cell antitumor activity. Here, we show that the spleen critical site harboring CD8 functionally segregate based on differential Cxcr3 Klrg1 expression. Cxcr3+ Klrg1- express memory stem marker Tcf1, whereas Cxcr3-Klrg1 + GzmB consistent with terminal...
This review provides an update on the role of operative laparoscopy in infertility treatment. The areas discussion include laparoscopic surgery for proximal and distal tubal disease, polycystic ovarian syndrome, endometriosis, assisted reproduction.
We explore how Deep Learning (DL) can be utilized to predict prognosis of acute myeloid leukemia (AML). Out TCGA (The Cancer Genome Atlas) database, 94 AML cases are used in this study. Input data include age, 10 common cytogenetic and 23 most mutation results; output is the (diagnosis death, DTD). In our DL network, autoencoders stacked form a hierarchical model from which raw compressed organized high-level features extracted. The network written R language designed for given case (DTD...
Cough, cough. Is that person sick, or do they just have a throat tickle? A growing body of research suggests pathogen threats shape key aspects human sociality. However, less has investigated specific processes involved in threat detection. Here, we examine whether perceivers can accurately detect using an understudied sensory modality—sound. Participants four studies judged cough and sneeze sounds were produced by people infected with communicable disease not. We found no evidence...
Abstract Virilization in pregnancy due to borderline mucinous ovarian tumors is very rare. A case of a 28‐year‐old patient who was noted at 28 weeks' gestation have marked virilization with raised serum androgens, ascites and large complex right adnexal mass presented. Delivery carried out by cesarean section surgery tumor the ovary. Histology revealed stromal luteinization, but there no evidence invasion. Serum androgens returned normal levels following maternal had resolved 6‐week...
Humans have a universal drive to understand other people’s intentions and behavior. From an evolutionary perspective, being perceptive about others in the social world—especially strangers—comes with host of benefits that promote survival (Cosmides & Tooby, 1992). People need decide whether person poses threat or opportunity, quickly accurately enough. Fortunately, humans well-developed, parsimonious method for perceiving others, where individuals situations we encounter are...
Abstract Background Esophageal adenocarcinoma (EAC) has become the predominant type of esophageal cancer in Western countries. Early diagnosis and intervention EAC significantly reduces disease mortality. A previous study identified a panel novel serum glycoprotein biomarkers that were associated with EAC, enabling development prototype diagnostic blood test, PromarkerEso. The current aimed to validate PromarkerEso an independent cohort patients EAC. Methods Blood samples from 165...
<h3>Background</h3> While immune checkpoint blockade (ICB) produces long-lasting remission in some patients, they may cause serious related adverse events (irAEs) that can result morbidity and mortality. irAEs have been increasingly recognized to stem from autoimmune-like activation of the adaptive system. Here, we analyzed pre-treatment peripheral blood mononuclear cells (PBMCs) patients with advanced melanoma treated ICB uncover processes underlying irAE occurrence if onset be predicted....
Objective: We explored how Deep Learning can be utilized to predict the prognosis of acute myeloid leukemia. Methods: Out The Cancer Genome Atlas database, 94 leukemia cases were used in this study. Input data included age, 10 most common cytogenetic and 23 mutation results; output was (diagnosis death). In our network, autoencoders stacked form a hierarchical model from which raw compressed organized, high-level features extracted. network written R language designed for given case death...
Abstract Recent advances in immunotherapy demonstrate the need to further understand characteristics of an individual cancer patient’s immune system and how it influences responses treatment. Here, we developed immunoprofiling platform evaluate features blood patients test hypothesis that peripheral cell heterogeneity could be used stratify these into different categories or immunotypes monitor disease progression treatment response. To end, established a unique diagnostic assay analytical...
Abstract Pancreatic ductal adenocarcinoma (PDA) has a dismal 5-year survival rate of 10%. Lethality is attributed to late diagnosis, early metastasis, and therapeutic resistance. We identified pancreatic tumor cells derived from mice which resist immunotherapy (e.g., escape variants, EV) rapidly metastasize upon re-implantation into the pancreas syngeneic immunocompetent mice. EVs retain dominant antigen, despite defect in IFNg-inducible MHC class I upregulation, remain sensitive antigen...