A5030763134- Logic, Reasoning, and Knowledge
- Formal Methods in Verification
- Melanoma and MAPK Pathways
- Logic, programming, and type systems
- Semantic Web and Ontologies
- Multi-Agent Systems and Negotiation
- Protein Degradation and Inhibitors
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Advanced Breast Cancer Therapies
- Advanced Algebra and Logic
- Access Control and Trust
- Software Reliability and Analysis Research
- Software Testing and Debugging Techniques
- Service-Oriented Architecture and Web Services
- Aviation Industry Analysis and Trends
- Topic Modeling
- Distributed and Parallel Computing Systems
- Evolutionary Algorithms and Applications
- Metaheuristic Optimization Algorithms Research
- semigroups and automata theory
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Innovative Teaching and Learning Methods
- Usability and User Interface Design
The University of Western Australia
2016-2025
AstraZeneca (United Kingdom)
2008-2023
Bioscience Research
2023
DePaul University
2015-2019
Belden (United States)
2015-2019
Loyola University Chicago
2017
University of Bedfordshire
2004-2016
University of Reading
2007-2012
The Netherlands Cancer Institute
2012
AstraZeneca (Netherlands)
2012
Selumetinib (AZD6244, ARRY-142886) is a selective, non-ATP-competitive inhibitor of mitogen-activated protein/extracellular signal-regulated kinase (MEK)-1/2. The range antitumor activity seen preclinically and in patients highlights the importance identifying determinants response to this drug. In large tumor cell panels diverse lineage, we show that MEK does not have an absolute correlation with mutational or phospho-protein markers BRAF/MEK, RAS, phosphoinositide 3-kinase (PI3K) activity....
Abstract Background Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. To tailor CRC treatment, it essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological clinical characteristics second match these cell lines for which extensive pharmacological data available, thus linking targeted therapies most likely respond treatment. Methods We applied new unsupervised, iterative approach stratify tumor samples into...
Abstract Background Homologous recombination deficiency (HRD) is a phenotype that characterized by the inability of cell to effectively repair DNA double-strand breaks using homologous (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, which target destruction cancer cells working concert with HRD through synthetic lethality. However, identify patients these...
In this paper we present a process model for developing usable cross-cultural websites. Compatible with ISO 13407, the documents an abstraction of design focusing on cultural issues in development. It provides framework which variety user-based and expert-based techniques analysis are placed within life-cycle website model, relate practical approaches to theories models culture discuss relevance such process. particular focus four key concerns: how audit local attractors can inform process;...
Electronic fraud is highly lucrative, with estimates suggesting these crimes to be worth millions of dollars annually. Because its complex nature, electronic detection typically impractical solve without automation. However, the creation automated systems detect very difficult as adversaries readily adapt and change their fraudulent activities which are often lost in magnitude legitimate transactions. This study reviews most popular types existing nature-inspired methods that used for them....
Experimental and computational THz (or far-infrared) spectra of polycrystalline valine samples are reported. The experimental have been measured using time-domain spectroscopy. Spectra the pure enantiomers, both D L, as well DL racemate taken at room temperature low (78 K). L enantiomers essentially identical, they markedly different from racemate. In addition, a temperature-dependent study L-valine was undertaken in which absorption maxima were found to red shift function increasing...
Selumetinib (AZD6244; ARRY-142886) is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. We evaluated the effects selumetinib 31 human breast cancer cell lines 43 non-small lung (NSCLC) to identify characteristics correlating with vitro sensitivity MEK inhibition. IC(50) <1 micromol/L (considered sensitive) was seen 5 15 NSCLC lines, correlation between raf mutations (P = 0.022) ras 0.045). Evaluation 27...
Wastewater treatment plants are complex, non-linear, engineered systems of physical, biological and chemical processes operating at different timescales. Sensor used to monitor wastewater in order ensure public safety for efficient management the plants. However, parameters interest can require expensive or inaccurate sensors may off-site laboratory analysis. For example, ammonium is important as a prime indicator efficiency highly regulated discharge water. But also over <inline-formula...
Much work is underway within the broad next generation technologies community on issues associated with development of services to foster collaboration via integration distributed and heterogeneous data systems technologies. Various technology-driven paradigms have emerged, including Web Services, 2.0, Pervasive, Grids Cloud Computing. Recently, some new Situated Computing Crowd Sourcing. In this exploratory paper, we aim be visionary, thus, offer an overview highlighting relationships...
FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected amplified patients by FISH. Lung cancer cell lines were profiled for sensitivity to AZD4547, a potent, selective inhibitor FGFRs 1-3. Sensitivity inhibition was associated but not wholly predicted increased gene copy number. Additional biomarker assays evaluating expression correlation between clinical tissues are therefore warranted. We validated nanoString mRNA analysis 194 genes, including FGFRs,...
In mining, manufacturing and industrial process industries, maintenance procedures are used as an aid to guide technicians through complex manual tasks. These not machine-readable, cannot support reasoning in digitally integrated systems. Procedure documents contain unstructured text stored a variety of formats. The aim this work is query information held real procedures. To achieve this, we develop ontology for using the OWL 2 description language. We leverage classes object properties from...
We propose various logical semantics for change of awareness. The setting is that multiple agents may become aware facts or other agents, forget about them. model these dynamics by quantifying over propositional variables and agent variables, in a multi-agent epistemic language with awareness operators, employing notion bisimulation clause `same awareness'. quantification all different ways which an can (or forget).
In this 'visionary' paper, we describe how a semiotic ladder, together with supportive trust agent, can be used to address 'soft' issues in the context of collaborative Virtual Organisations (VOs). The intention is offer all parties better support for (as reputation) management, including reduction risk and improved reliability VO e-services. ladder intended e-service life cycle through articulation e-trust at various levels system abstraction, as measurable confidence level. A novel agent...