A5046617764- BRCA gene mutations in cancer
- Pancreatic and Hepatic Oncology Research
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- DNA Repair Mechanisms
- COVID-19 and healthcare impacts
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Colorectal Cancer Screening and Detection
- Advanced Causal Inference Techniques
- Ocular Oncology and Treatments
- Ovarian cancer diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Health Systems, Economic Evaluations, Quality of Life
- Polyomavirus and related diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Melanoma and MAPK Pathways
- Brain Metastases and Treatment
University of Utah
2021-2025
Huntsman Cancer Institute
2018-2025
City of Hope
2017-2025
City Of Hope National Medical Center
2017-2024
Yale University
2023
The Ohio State University
2017-2022
The Ohio State University Wexner Medical Center
2016-2022
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2022
University of Arizona
2008-2018
Dana-Farber Cancer Institute
2018
The purpose of this study was to quantify the risk cancers other than melanoma among family members CDKN2A mutation carriers using data from Genes, Environment and Melanoma study. Relative risks (RRs) all non-melanoma first-degree relatives (FDRs) patients with mutations (n = 65) FDRs without 3537) were calculated as ratio estimated event rates (number cancers/total person-years) in vs noncarriers exact Clopper-Pearson-type tests 95% confidence intervals (CIs). All statistical two-sided....
This analysis describes the outcome for patients who received targeted therapy (TT) prior to or following high-dose interleukin-2 (HD IL-2).Patients with renal cell carcinoma (n = 352) receiving HD IL-2 were enrolled in ProleukinR Observational Study Evaluate Treatment Patterns and Clinical Response Malignancy (PROCLAIMSM) beginning 2011. Statistical analyses performed using datasets as of September 24, 2015.Overall, there 4% complete response (CR), 13% partial (PR), 39% stable disease (SD),...
Approximately 40% of patients with uveal melanoma (UM) will develop metastatic disease. Tumors measuring at least 12mm in basal diameter a class 2 signature, as defined by widely used gene expression-profiling test, are associated significantly higher risk metastasis, median time to recurrence 32 months. No therapy has been shown reduce this risk.This was single-arm, multicenter study high-risk UM who received definitive treatment primary disease and had no evidence metastasis. Patients were...
Abstract Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs between May 2020 and March 2022 were collected, with defined as participants PRECEDE meeting guideline-based criteria for PDAC Of 1,273 enrolled, 1,113 eligible inclusion, 47.2% familial...
Background Type 1 diabetes mellitus (T1DM) is a rare, but serious immune-related adverse event (irAE) of immune checkpoint inhibitors (ICIs). Our goal was to characterize treatment outcomes associated with ICI-induced T1DM through analysis clinical, immunological and proteomic data. Methods This single-center case series patients solid tumors who received ICIs subsequently had new diagnosis T1DM. ICD codes C-peptide levels were used identify for chart review confirm Baseline blood specimens...
This study aimed to estimate the incremental lifetime effects, costs, and net monetary benefit (NMB) of knowing BRCA information by universal genetic testing all US women without breast cancer turning 40 in a given year, cumulative savings or losses yearly cohort over 16 years. We compared two strategies: (1) 'with information' (2) 'without information.'Incremental NMB (INMB) was calculated as monetized per person status. The value (cumulated INMB) estimated multiplying INMB with eligible...
Patients with advanced melanoma who progress on standard-dose ipilimumab (Ipi) + nivolumab continue to have poor prognosis. Studies support a dose–response activity of Ipi, and one promising combination is Ipi 10 mg/kg (Ipi10) temozolomide (TMZ). We performed retrospective cohort analysis patients treated Ipi10 TMZ in the immunotherapy refractory/resistant setting (n = 6, all progressed after prior nivolumab), using similar Ipi3 6) as comparison. Molecular profiling by whole-exome sequencing...
Recent advances in molecular genetics have identified several genes associated with inherited susceptibility to cancer and provided a means begin identifying individuals families an increased risk of cancer. This rapid expansion knowledge about has implications for all aspects management, including prevention, screening, treatment. These guidelines specifically address hereditary breast/ovarian syndrome (HBOC), Li-Fraumeni syndrome, Cowden syndrome. were developed understanding that much our...
OBJECTIVES: Colorectal cancer (CRC) is a feared complication of chronic ulcerative colitis (UC). Annual endoscopic surveillance recommended for the detection early neoplasia. 5-Aminosalicylates (5-ASAs) may prevent some UC-associated CRC. Therefore, in patients prescribed 5-ASAs maintenance remission, annual might be overly burdensome and inefficient. We aimed to determine ideal frequency with UC maintained on 5-ASAs. METHODS: performed systematic reviews literature, created Markov computer...
Because nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth in vitro , we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident 119 melanoma-free controls completed structured interview assessing risk factors. The unadjusted odds ratio (OR) for use nonaspirin 0.58 (95% CI 0.31–1.11), comparison controls. After adjustment...
Background: Previous reports have suggested that acupressure is effective in reducing pain and improving sleep quality; however, its effects on alertness not been characterized. Objectives: The aim of this study was to determine whether two different treatments opposing a full-day classroom setting. Design: This cross-over (two-treatments; three periods), single-blinded, randomized trial. Setting: University Michigan School Public Health the Subjects: Students attending course clinical...
Non-Hodgkin lymphoma (NHL) is the most common cancer in people with HIV. Although 95% of HIV patients are developing countries like Peru, majority these studies have been conducted developed countries. In this study we aim to evaluate prognostic factors associated outcomes positive undergoing systemic therapy for treatment NHL.This retrospective includes NHL seen Instituto Nacional de Enfermedades Neoplasicas (INEN) between 2004 2014. Patients were divided into two groups: antiretroviral...