A5051071221- Pancreatic and Hepatic Oncology Research
- Ethics in Clinical Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- COVID-19 and healthcare impacts
- Advanced Causal Inference Techniques
- Ovarian cancer diagnosis and treatment
- Intestinal Malrotation and Obstruction Disorders
- Liver Disease and Transplantation
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Neonatal Health and Biochemistry
- Endometrial and Cervical Cancer Treatments
- Congenital Anomalies and Fetal Surgery
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Heavy Metal Exposure and Toxicity
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
Arbor Research Collaborative for Health
2018-2023
Mayo Clinic in Florida
2015-2016
WinnMed
2015
Mayo Clinic
2015
Background and Aims: In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP). Infants with persistently high levels invariably need liver transplant, but those achieving normalized have a less certain disease course. We hypothesized that bile acid could help in the latter group. Approach Results: Participants atresia from Childhood Liver Disease Research Network were included if they had 6 months KP stored samples 6‐month post‐KP clinic...
Abstract Background and Aims The natural history of gastroesophageal variceal hemorrhage (VH) in biliary atresia (BA) is not well characterized. We analyzed risk factors, incidence, outcomes VH a longitudinal multicenter study. Approach Results Participants enrolled either an incident (Prospective Database Infants with Cholestasis [PROBE]) or prevalent (Biliary Atresia Study Children [BASIC]) cohort BA were included. Variceal was defined based on gastrointestinal bleeding the presence...
Abstract Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs between May 2020 and March 2022 were collected, with defined as participants PRECEDE meeting guideline-based criteria for PDAC Of 1,273 enrolled, 1,113 eligible inclusion, 47.2% familial...
Approximately 50% of infants with biliary atresia (BA) undergoing Kasai portoenterostomy show survival native liver (SNL) at age 2 years. Predictors disease progression after years are unknown, despite estimates 20%‐30% transplant (LT) between and 18 We sought to address this knowledge gap by developing prognostic models in participants the multicenter prospective National Institutes Health‐supported Childhood Liver Disease Research Network. extracted 14 clinical biochemical variables...
ABSTRACT Objectives: The aim of the study was to assess neurodevelopmental outcomes among children with biliary atresia (BA) surviving their native liver at ages 3 12 years and evaluate variables that associate neurodevelopment. Methods: Participants (ages 3–12 years) in a prospective, longitudinal, multicenter underwent testing Weschler Preschool Primary Scale Intelligence, 3rd edition (WPPSI‐III, 3–5 Intelligence for Children, 4th (WISC‐IV, 6–12 years). Continuous scores were analyzed...
Background: Alterations in both mitochondrial DNA (mtDNA) and nuclear genes affect mitochondria function, causing a range of liver-based conditions termed hepatopathies (MH), which are subcategorized as mtDNA depletion, RNA translation, deletion, enzymatic disorders. We aim to enhance the understanding pathogenesis natural history MH. Methods: analyzed data from patients with MH phenotypes identify genetic causes, characterize spectrum clinical presentation, determine outcomes. Results:...
Purpose: To test a novel bladder health tutorial on use of the Knack for overcoming control challenges. The Knack-tutorial is self-administered vignette-based instructional program preempting challenges in daily life (urgency, stress-leakage, or urge-leakage) through anticipatory, well-timed pelvic floor muscle contraction at moment challenge. Materials and Methods: This randomized controlled trial pilot 108 women with stress mixed urinary incontinence. group saw 15-minute slide show 10...
<b><i>Objective:</i></b> Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods focus specifically on interactions between candidate prognostic variables. <b><i>Methods Results:</i></b> Univariate, multivariate, elastic net modeling of 42 variables were applied a cohort 542 ovarian patients with 393 episodes recurrence/death. In univariate...
ABSTRACT Objectives: The aim of the study was to determine frequency and natural history infantile idiopathic cholestasis (IC) in a large, prospective, multicenter cohort infants. Methods: We studied 94 cholestatic infants enrolled up 6 months age NIDDK ChiLDReN (Childhood Liver Disease Research Network) “PROBE” protocol with final diagnosis IC; they were followed 30 age. Results: Male sex (66/94; 70%), preterm birth (22/90 data; 24% born at < 37 weeks’ gestational age), low weight...
To evaluate neurodevelopmental status among children with inherited cholestatic liver diseases native and variables predictive of impairment.Participants Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC), alpha 1 antitrypsin deficiency (A1AT) enrolled in a longitudinal, multicenter study completed the Wechsler Preschool Primary Scale Intelligence-III or Intelligence for Children-IV. Full Quotient (FSIQ) was analyzed continuously categorically (>100, 85-99, 70-84,...
687 Background: The international, multi-center Pancreatic Cancer Early Detection (PRECEDE) Consortium enrolls high-risk individuals (HRIs) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Enrollment began in 2020, and despite challenges related to the COVID-19 pandemic, PRECEDE rapidly accrued a large cohort of HRIs. purpose this study is describe characteristics assess racial, ethnic, sex-based disparities. Methods: (NCT04970056) prospective, multicenter focused on...
<div>Abstract<p>Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs between May 2020 and March 2022 were collected, with defined as participants PRECEDE meeting guideline-based criteria for PDAC Of 1,273 enrolled, 1,113 eligible...
<div>Abstract<p>Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs between May 2020 and March 2022 were collected, with defined as participants PRECEDE meeting guideline-based criteria for PDAC Of 1,273 enrolled, 1,113 eligible...