A5049560811- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Platelet Disorders and Treatments
- Blood donation and transfusion practices
- Vascular Anomalies and Treatments
- Abdominal vascular conditions and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Complement system in diseases
- Congenital Heart Disease Studies
- Immune cells in cancer
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
Texas A&M University
2022-2023
Methodist Hospital
2023
Children's Hospital of Philadelphia
2019-2021
Hospital of the University of Pennsylvania
2017-2021
University of Pennsylvania
2017
Vanderbilt University
2017
The Ohio State University
2017
Rationale: The objective of this autopsy study was to determine whether gastrointestinal angiodysplasia develops during continuous-flow left ventricular assist device (LVAD) support. Objective: LVAD support causes pathologic degradation von Willebrand factor (vWF) and bleeding from at an alarming rate. It has been speculated that itself may cause angiodysplasia. relationship abnormal vWF metabolism is unknown. We tested the hypothesis vascularity Methods Results: Small bowel obtained...
Background Gastrointestinal bleeding from angiodysplasia is a major problem in continuous-flow left ventricular assist device (LVAD) patients. LVAD shear stress causes pathologic degradation of VWF (von Willebrand factor). A mechanistic relationship between and has not been explored. We tested 2 novel hypotheses: (1) clinical hypothesis: fragments are elevated patients that develop (2) vitro generated during support alter angiogenesis, which may contribute to angiodysplasia. Methods Results...
In utero hypoxia is a major cause of neonatal morbidity and mortality predisposes to adult cardiovascular disease. No therapies exist correct fetal hypoxia. new ex support system, we tested the hypothesis that hypoxemic fetus impairs myocardial development, whereas normoxic allows normal development. Preterm lambs were connected via umbilical vessels low-resistance oxygenator placed in sterile-fluid environment. Control fetuses received oxygenation, subphysiologic oxygenation. Fetuses with...
Children with a bidirectional superior cavopulmonary (Glenn) circulation develop angiodysplasia and pulmonary arteriovenous malformations (AVMs). The von Willebrand factor (vWF)-angiopoietin axis plays major role in AVM formation multiple diseases. We observed derangements global angiogenic signaling, vWF metabolism, angiopoietins, vitro angiogenesis children Glenn versus controls within systemic circulations. These findings support the novel hypothesis that abnormalities vWF-angiopoietin...