A5004071253- Neurogenesis and neuroplasticity mechanisms
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Molecular Biology Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Medical Imaging and Pathology Studies
- Cancer therapeutics and mechanisms
- Nerve injury and regeneration
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- LGBTQ Health, Identity, and Policy
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Pancreatitis Pathology and Treatment
The Ohio State University Wexner Medical Center
2024-2025
Broad Institute
2010-2025
American Academy of Neurology
2024
Albany Medical Center Hospital
2024
University of Massachusetts Chan Medical School
2024
UMass Memorial Medical Center
2024
The Ohio State University
2022-2024
Toronto Western Hospital
2024
University of Toronto
2024
Johns Hopkins University
2013-2023
The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor-armed T cells (CART-19), but relapses epitope loss occur in 10% to 20% of pediatric responders. We detected hemizygous deletions spanning the locus and de novo frameshift missense mutations exon 2 some relapse samples. However, we also discovered alternatively spliced mRNA species, including one lacking 2. Pull-down/siRNA experiments identified SRSF3 as a splicing...
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout body, including in CNS and immune system. Whether bile acid metabolism abnormal MS unknown. Using global targeted metabolomic profiling, we identified lower levels circulating multiple cohorts adult pediatric patients with compared controls. In white matter lesions from brain tissue, noted presence glial cells. To...
Mutations in the potassium channel subunit KCNQ2 lead to benign familial neonatal convulsions, a dominantly inherited form of generalized epilepsy. In heterologous cells, expression yields voltage-gated channels that activate slowly (τ, ∼0.1 sec) at subthreshold membrane potentials. associates with KCNQ3, homolog, heteromeric responsible for M current ( I ) superior cervical ganglion (SCG) neurons. Muscarinic acetylcholine and peptidergic receptors inhibit SCG , causing slow EPSPs enhancing...
Abstract Objective Repair of myelin injury in multiple sclerosis may fail, resulting chronic demyelination, axonal loss, and disease progression. As cellular pathways regulated by phosphatase tensin homologue deleted on chromosome 10 (PTEN; eg, phosphatidylinositol‐3‐kinase [PI‐3K]) have been reported to enhance axon regeneration oligodendrocyte maturation, we investigated potentially beneficial effects Pten loss function the lineage remyelination. Methods We characterized numbers sheath...
Muscle-eye-brain disease (MEB) and Walker Warburg Syndrome (WWS) belong to a spectrum of autosomal recessive diseases characterized by ocular dysgenesis, neuronal migration defects, congenital muscular dystrophy. Until now, the pathophysiology MEB/WWS has been attributed alteration in dystroglycan post-translational modification. Here, we provide evidence that mutations gene coding for major basement membrane protein, collagen IV alpha 1 (COL4A1), are novel cause MEB/WWS. Using combination...
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown features these immune oligodendroglia are poorly defined. We generated class I II transgenic reporter mice define dynamics inflammatory demyelination, providing a means monitor activation diverse cell types living roles aging, injury, disease.Nerve cells brain spinal cord surrounded by layer insulation called myelin that allows transmit messages...
Summary: Purpose: Brain malformations are a common cause of intractable epilepsy and cognitive dysfunction in children. Prenatal exposure to the teratogen methylazoxymethanol (MAM) is rodent model brain malformation featuring loss lamination, clusters displaced hippocampal cells, pharmaco‐resistance antiepileptic drugs. In normotopic hippocampus, expression postsynaptic glutamate receptors transporters regulating neurotransmitter reuptake critical factors modulating excitation synaptic...
To summarize the literature on neurologic care for transgender and gender-diverse (TGD) people provide implications clinical practice.
Macrophages are a pivotal cell type within the synovial lining and sub-lining of joint, playing crucial role in maintaining homeostasis synovium. Although fate-mapping techniques have been employed to differentiate macrophages from other myeloid cells, no comprehensive study has yet conducted mouse macrophage compartment. In this study, we present, for first time, lineage tracing results 18 myeloid-specific models peripheral blood (PB) tissue. The identification monocyte-lineage cells...
Abstract The discovery and development of direct inhibitors KRAS is transforming therapeutic options across diverse cancer types. Here, we use the PRISM collection nearly 900 cell lines, including more than 150 KRAS-mutant to characterize 19 KRAS-targeting or degraders, G12C-, G12D-, pan-KRAS inhibitors. Agents were tested at 8 doses (threefold dilution) for 5 days a median 883 lines. For each agent, assessed its selectivity correlation with mutation status genetic dependency. line,...
Therapeutic targeting of initiating oncogenes is the mainstay precision medicine. Considerable efforts have been expended toward silencing MYC, which drives many human cancers including Burkitt lymphomas (BL). Yet, effects MYC on standard-of-care therapies are poorly understood. Here we found that inhibition transcription renders B-lymphoblastoid cells refractory to chemotherapeutic agents. This suggested in context chemotherapy, stabilization Myc protein could be more beneficial than its...
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that may coexist in the multiple sclerosis population and remain undiagnosed. AIH has previously been reported following treatment with interferon beta, glatiramer acetate, natalizumab high dose corticosteroids people (MS). We present rare case of autoimmune onset after B cell depletion ocrelizumab person Two weeks second ocrelizumab, patient presented jaundice acute injury. Liver biopsy revealed pathological features...