A5061161592- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Adolescent and Pediatric Healthcare
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Sleep and related disorders
- Suicide and Self-Harm Studies
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Cognitive Abilities and Testing
- Cardiac Health and Mental Health
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Family and Disability Support Research
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
The University of Sydney
2013-2025
The large contribution of psychiatric disorders to premature death and persistent disability among young people means that earlier identification enhanced long-term care for those who are most at risk developing life-threatening or chronic is critical. Clinical staging as an adjunct diagnosis address emerging has been proposed presenting care; however, the longer-term utility this system not established.To determine rates transition from later stages anxiety, mood, psychotic, comorbid...
Objective To identify trajectories of social and occupational functioning in young people during the two years after presenting for early intervention mental health care; to demographic clinical factors that influence these trajectories. Design Longitudinal, observational study care. Setting Two primary care-based services at Brain Mind Centre (University Sydney), 1 June 2008 – 31 July 2018. Participants 1510 aged 12‒25 who had presented with anxiety, mood, or psychotic disorders, whom...
The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problems, in order longitudinally explore and refine clinical staging model the development progression disorders. This paper presents baseline demographic characteristics cohort, particularly nature severity psychopathology.All eligible attending one four headspace services were invited participate, completed battery self-report interviewer-administered measures...
Mental disorders typically emerge during adolescence and young adulthood put people at risk for prolonged socioeconomic difficulties. This study describes the longitudinal course of social occupational functioning attending primary care-based, early intervention services.A receiving mental healthcare.Data were collected between January 2005 August 2017 from a designated care-based health service.554 (54% women) aged 12-32 years.A systematic medical file audit clinical functional information...
A priority for health services is to reduce self-harm in young people. Predicting challenging due their rarity and complexity, however this does not preclude the utility of prediction models improve decision-making regarding a service response terms more detailed assessments and/or intervention. The aim study was predict within six-months after initial presentation.The included 1962 people (12-30 years) presenting youth mental Australia. Six machine learning algorithms were trained tested...
Abstract Aim An estimated 75% of mental disorders begin before the age 24 and approximately 25% 13–24‐year‐olds are affected by at any one time. To better understand ideally prevent onset post‐pubertal disorders, a clinical staging model has been proposed that provides longitudinal perspective illness development. This heuristic takes account differential effects both genetic environmental risk factors, as well markers relevant to stage illness, course or prognosis. The aim T ransitions S...
Purpose The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical functional domains longitudinally in young people presenting for mental health care treatment. Longitudinal tracking of this will allow investigation the relationships between outcome across course care. Subsets have completed detailed neuropsychological neurobiological assessments, permitting associations these measures longitudinal course. Participants Young (aged 12–30) to clinics coordinated by BMC were...
Staging models for youth mental health aim to locate clinical presentations on a spectrum from at-risk states persistent disorder and predict future illness trajectories. Our previous publications trans-diagnostic staging proposed three pathophysiological subgroups of major mood or psychotic disorders in ('hyperarousal-anxious depression', 'circadian-bipolar spectrum', 'neurodevelopmental-psychosis'). This study aims investigate differences objective measures 24hr sleep-wake patterns,...
We investigated the prevalence of elevated metabolic and inflammatory risk groups in youth seeking care for emerging mental disorders. Among 124 participants (27.3±5.9 years), we analysed fasting insulin (FI), blood glucose (FBG), homeostasis model assessment resistance (HOMA2-IR), C-reactive Protein (CRP). FI (≥10mU/L) CRP (≥1mg/L) were used to categorise metabolic- or inflammatory-risk groups, demographic/clinical features compared. Inflammatory was common (58% [n=73] with CRP), as (38%...
While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms these cohorts understudied. We examined 24-h wrist emerging exploring associations clinical stage and proposed illness subtypes. Youth ( n = 306, 23.42 ± 4.91 years, 65% females) accessing mental health care 48 healthy controls (23.44 3.38 60% were examined. Skin parameters including rhythm-adjusted mean temperature, inter-daily stability (day-to-day consistency), intra-daily...
Complaints of chronic fatigue lasting weeks or longer are common during adolescence. Little is known about factors associated with in youth mood disorders potential sex-specific associations. 496 young people (mean age = 18.36-years, SD 3.22; 69 % female) seeking help for mental healthcare were assessed on psychological symptoms, lifestyle, and sleep at baseline 12-months later. Fatigue was defined as a score ≥3 the somatic subscale Somatic Psychological Health Report. Logistic regression...
Neurocognitive impairments robustly predict functional outcome. However, heterogeneity in neurocognition is common within diagnostic groups, and data-driven analyses reveal homogeneous neurocognitive subgroups cutting across boundaries.
Machine learning (ML) has shown promise in modelling future self-harm but is yet to be applied key questions facing clinical services. In a cohort of young people accessing primary mental health care, this study aimed establish (1) the performance models predicting deliberate (DSH) compared suicide attempt (SA), (2) new-onset or repeat behaviour, and (3) relative importance factors these outcomes.802 aged 12-25 years attending services had detailed social assessments at baseline 509...
Neuropsychiatric disorders (including substance misuse) are associated with the greatest burden of functional disability in young people, and contributory factors remain poorly understood. Early-onset use is one candidate risk factor which may inform prognosis facilitate direction interventions aiming to curtail impairment. Accordingly, we modelled associations between early-onset alcohol, tobacco, cannabis amphetamine-type stimulants (ATSs) longitudinal socio-occupational functioning...
Abstract Neurocognitive impairment is commonly associated with functional disability in established depressive, bipolar and psychotic disorders. However, little known about the longer-term implications of these impairments early phase transdiagnostic cohorts. We aimed to examine associations between neurocognition functioning at baseline over time. used mixed effects models investigate neurocognitive test scores longitudinal social occupational (“Social Occupational Functioning Assessment...
Clinical staging proposes that youth-onset mental disorders develop progressively, and active treatment of earlier stages should prevent progression to more severe disorders. This retrospective cohort study examined the longitudinal relationships between clinical multiple functional outcomes within first 12 months care.
Many adolescents and young adults with emerging mood disorders do not achieve substantial improvements in education, employment, or social function after receiving standard youth mental health care. We have developed a new model of care referred to as 'highly personalised measurement-based care' (HP&MBC). HP&MBC involves repeated assessment multidimensional domains morbidity enable continuous clinical decision-making. Although is common medical disease management, it practice health. This...
Introduction Mental disorders are a leading cause of long-term disability worldwide. Much the burden mental ill-health is mediated by early onset, comorbidities with physical health conditions and chronicity illnesses. This study aims to track period among young people presenting Australian services facilitate more streamlined transdiagnostic processes, highly personalised measurement-based care, secondary prevention enhanced outcomes. Methods analysis Recruitment this large-scale,...
Introduction Metformin is a medication likely to improve measures of cardiometabolic disturbance in young people with mental illness. Evidence also suggests metformin may depressive symptoms. This 52-week double-blind randomised control trial (RCT) aims investigate the efficacy pharmacotherapy as an adjunct healthy lifestyle behavioural intervention improving outcomes, and depressive, anxiety psychotic symptoms youth clinically diagnosed major mood syndromes. Methods analysis At least 266...
Approximately 75% of major mental illness occurs before the age 25 years. Despite this, our capacity to provide effective, early and personalised interventions is limited by insufficient evidence for characterising early-stage, less specific, presentations disorders in youth populations. This article describes protocol setting up a large-scale database that will collect longitudinal, prospective data incorporate clinical, social occupational function, neuropsychological, circadian,...