A5108564558- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Nosocomial Infections in ICU
- Breast Cancer Treatment Studies
- Metalloenzymes and iron-sulfur proteins
- Clostridium difficile and Clostridium perfringens research
- Breast Lesions and Carcinomas
- Workplace Health and Well-being
- Employment and Welfare Studies
- Health disparities and outcomes
- Sleep and Work-Related Fatigue
- Microscopic Colitis
- Child Abuse and Trauma
- Electrocatalysts for Energy Conversion
- Cancer Genomics and Diagnostics
- Enzyme Structure and Function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced battery technologies research
- Metal-Catalyzed Oxygenation Mechanisms
- Sepsis Diagnosis and Treatment
- AI in cancer detection
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Orthopedic Infections and Treatments
- Chronic Kidney Disease and Diabetes
Martin Luther University Halle-Wittenberg
2014-2019
The University of Western Australia
1997-2019
Queen Elizabeth II Medical Centre
2003-2019
Pathwest Laboratory Medicine
2015-2019
Winthrop-University Hospital
2019
Fiona Stanley Hospital
2019
University of Oxford
2016
St George's, University of London
2010-2016
May Institute
2012
University College London
2006-2011
OBJECTIVE. Child abuse has been associated with poorer physical health in adulthood, but less is known about childhood adversity more broadly, including neglect and family problems, or the pathways from to adult disease. We have examined how different stressful emotional neglectful adversities are related adiposity glucose control midadulthood, taking into account factors, whether relationships mediated by behaviors socioeconomic position. METHODS. This was a prospective longitudinal study...
To describe the impact of changes between employment and various forms non-employment, vice versa, on psychological wellbeing men women.Separate multivariate models for women were constructed to study association transitions episodes distress (general health questionnaire).13,359 from 5092 people aged 16-74 years in British household panel survey 1991 1998.Transitions paid either unemployment or long term sick leave associated with increased both women. Starting maternity staying home look...
OBJECTIVE Long-term implications of childhood obesity and BMI change over the life course for risk type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism 1) sensitive periods gain or 2) long duration overweight obesity. RESEARCH DESIGN AND METHODS Participants in 1958 British birth cohort with child glycosylated hemoglobin (HbA1c) at 45 years (n = 7,855). RESULTS Prevalence HbA1c ≥7 2%. gains child- adulthood were associated...
There is little information on how the duration of overweight or obesity during life affects risk for CKD. To investigate whether prolonged exposure to adult increases later CKD in a cumulative manner, we analyzed data from Medical Research Council National Survey Health and Development, socially stratified sample 5362 singleton children born 1 week March 1946 England, Scotland, Wales. Multiple imputation expanded analysis initial 1794 participants with complete 4584. This study collected...
Cortisol levels may be altered in childhood association with maltreatment (neglect, abuse and witnessing abuse) other adversities, yet little is known about whether effects on cortisol persist into later life.To establish psychosocial adversities predict mid-adulthood.Childhood were ascertained the 1958 British birth cohort was measured two saliva samples, one 45 min after awaking (T(1)) 3 h same day (T(2)), from 6524 participants aged years.No seen for or household dysfunction adult levels....
To explore the extent to which mental health effects of transitions into unemployment, or other forms non-employment, and vice versa, are mediated by financial changes.Longitudinal analysis British Household Panel Survey from 1991 2000. There were 89,264 person-years observation 14,686 individuals aged > =16 years. Main outcome measure was psychological distress measured 12-item General Health Questionnaire.Transitions unemployment associated with increased risk for men (adjusted odds ratio...
Few studies have examined the impact of childhood obesity on later kidney disease, and consequently, our understanding is very limited.Longitudinal population-based cohort.The Medical Research Council National Survey Health Development, a socially stratified sample 5,362 singletons born in 1 week March 1946 England, Scotland, Wales, which 4,340 were analyzed.Early-life overweight latent classes (never, prepubertal only, pubertal onset, or always), derived from repeated measurements body mass...
The incidence of Clostridium difficile-associated diarrhea (CDAD) has increased dramatically in hospitals worldwide during the past 2 decades. In Western Australia, this increase was most obvious 1980s, when there also an use third-generation cephalosporin antibiotics. A study epidemiology CDAD and cephalosporins 1993–2000 undertaken. From 1993 through 1998, remained relatively stable (2–3 cases per 1000 discharges annually). Then, a significant decrease occurred, from 2.09 (95% confidence...
Birth weight has been associated with the risk of type 2 diabetes in several studies. We investigated whether prenatal influences on birth (gestational age, parity, preeclampsia, prepregnancy BMI, smoking during pregnancy, and socioeconomic position [SEP]) were glucose metabolism midlife role for gestational age (BGA) adult adiposity mediating these associations.Data from 7,518 participants 1958 British Cohort information A1C at 45 years analyzed. Associations between exposures > or =6%...
Background Socio-economic position (SEP) and ethnicity influence type 2 diabetes mellitus (T2DM) risk in adults. However, the of SEP on emerging T2DM risks different ethnic groups contribution to differences young people have been little studied. We examined relationships between factors UK children South Asian, black African-Caribbean white European origin, using official National Statistics Classification (NS-SEC) assessed extent which NS-SEC explained factors. Methods Findings...
Abstract In this article, we assess the prevalence of child maltreatments, their co‐occurrence and associations with household dysfunction in a large population cohort. Information from 1958 British birth cohort on childhood abuse, neglect recorded at 45 years during was used. Prevalence calculated three samples: individuals each measure (n = 9310–15 583); 45‐year‐old participants 9310); all surviving to 17 313) includes imputed data. A cumulative score derived. Latent Class Analysis (LCA)...
'Oxygen-tolerant' [NiFe]-hydrogenases can catalyze H2 oxidation under aerobic conditions, avoiding oxygenation and destruction of the active site. In one mechanism accounting for this special property, membrane-bound accommodate a pool electrons that allows an O2 molecule attacking site to be converted rapidly harmless water. An important advantage may stem from having dimeric or higher-order quaternary structure in which electron-transfer relay chain partner is electronically coupled other....
Abstract Purpose This study examined the characteristics, incidence and prognostic factors of first AIDS-defining condition developed after more than one year continuous antiretroviral therapy (ART) among people living with HIV (PLHIV). Methods We used data from two multicentre observational cohorts PLHIV in Germany between 1999 2018. Our outcome was event that occurred during follow-up ART. Descriptive analyses at ART initiation, time AIDS most frequently observed types illnesses were...
Type VII ABC transporters are ATP-powered membrane protein complexes that drive key biological processes in the bacterial cell envelope. In E. coli, three of four systems have been extensively characterised including FtsEX-EnvC division complex, LolCDE-LolA lipoprotein trafficking machinery and MacAB-TolC efflux pump. Here we describe a fourth coli system, YbbAP-TesA, which combines transporter with multifunctional hydrolytic enzyme. Structures complete YbbAP-TesA YbbAP without bound ATP...
Objectives: To examine the relationships between exposure to workplace factors (night work, extended working hours, psychosocial work stress) and cortisol secretion, test whether interact, resulting in combined effects. Methods: Multiple linear logistic regression was used secretion 1958 British birth cohort at 45 years. Salivary measured twice on same day capture post-waking decline, facilitating analysis of different patterns: (1) time 1 (T1, minutes post-waking); (2) 2 (T2, 3 h after T1);...
<h3>Background</h3> The Cambridge Risk Score (CRS) was developed to screen for type 2 diabetes mellitus risk. We assessed the ability of CRS predict glycosylated hemoglobin (HbA<sub>1c</sub>) levels and determined whether better than body mass index (BMI) at predicting HbA<sub>1c</sub>levels in midlife. <h3>Methods</h3> included 7452 participants without known a biomedical survey 1958 British Birth Cohort 45 years age. Receiver operator characteristic curves were used compare BMI identify...
[NiFe]-hydrogenases (Hyd) bind a nickel-iron-based cofactor. The Fe ion of the cofactor is bound by two cyanide ligands and single carbon monoxide ligand. Minimally six accessory proteins (HypA-HypF) are necessary for NiFe(CN)2CO biosynthesis in Escherichia coli. It has been shown that anaerobically purified HypC-HypD-HypE scaffold complex carries Fe(CN)2CO moiety this In present study, we have HybG-HypDE used it to successfully reconstitute vitro active Hyd from E. HybG homologue HypC...
Social disadvantage across the life course is associated with a greater risk of coronary heart disease (CHD) and established CHD factors, but less known about whether novel factors show same patterns.The Medical Research Council National Survey Health Development was used to investigate associations between occupational socioeconomic position during childhood, early adulthood middle age markers inflammation (C-reactive protein, interleukin-6), endothelial function (Eselectin,...
During biosynthesis of [NiFe]-hydrogenase 2 (Hyd-2) Escherichia coli, a 15-amino-acid C-terminal peptide is cleaved from the catalytic large subunit precursor, pro-HybC. This removed only after NiFe(CN)2CO cofactor insertion by Hyp accessory protein machinery has been completed, suggesting that it regulatory function during enzyme maturation. We show here in hyp mutants fail to synthesize and insert NiFe cofactor, therefore retain peptide, Tat (twin-arginine translocon) signal on small HybO...