A5034291778- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nuclear Structure and Function
- Diagnosis and treatment of tuberculosis
- Extracellular vesicles in disease
- Clostridium difficile and Clostridium perfringens research
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- Oral microbiology and periodontitis research
- DNA Repair Mechanisms
- Cytokine Signaling Pathways and Interactions
- Parasites and Host Interactions
- Microtubule and mitosis dynamics
- Caveolin-1 and cellular processes
- Immune Response and Inflammation
- Ocular Diseases and Behçet’s Syndrome
- Lipid Membrane Structure and Behavior
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Cellular transport and secretion
- Malaria Research and Control
Universidade Católica de Brasília
2024
University of Lisbon
2009-2017
Instituto de Medicina Molecular João Lobo Antunes
2009-2010
Hospital de Egas Moniz
2009
University of Cambridge
2005
Cancer Research UK
2005
Abstract Cathepsins are proteolytic enzymes that function in the endocytic pathway, especially lysosomes, where they contribute directly to pathogen killing or indirectly, by their involvement antigen presentation pathways. Mycobacterium tuberculosis (MTB) is a facultative intracellular survives inside macrophage phagosomes inhibiting maturation phagolysosomes and thus avoiding low pH protease-rich environment. We previously showed mycobacterial inhibition of proinflammatory transcription...
Mycobacterium tuberculosis (Mtb) is a successful intracellular pathogen that thrives in macrophages (Mφs). There need to better understand how Mtb hijacks cellular processes like phagolysosome biogenesis, classical pathogenesis determinant. A central feature this microbial strategy the manipulation of actin Mφs. Here, we examine role microRNAs (miRNAs) as potential mechanism regulation actin-mediated events leading phagocytosis context mycobacteria infection. Given non-virulent smegmatis...
The success of tuberculosis (TB) bacillus, Mycobacterium (Mtb), relies on the ability to survive in host cells and escape immune surveillance activation. We recently demonstrated that Mtb manipulation lysosomal cathepsins macrophages leads decreased enzymatic activity pathogen survival. In addition, while searching for microRNAs (miRNAs) involved posttranscriptional gene regulation during mycobacteria infection human macrophages, we found selected miRNAs such as miR-106b-5p were specifically...
Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and microti) but not bovis avium. The latter two are mycobacterial involved in human cattle HIV coinfections, respectively. PZA a first-line agent for the treatment of requires activation by pyrazinamidase to form metabolite pyrazinoic acid (POA). As result this mechanism, resistance PZA, as often found patients, caused point mutations pyrazinamidase. In previous work, we have shown...