A5048956500- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Global Maternal and Child Health
- Dengue and Mosquito Control Research
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Parasite Biology and Host Interactions
- Travel-related health issues
- Parasitic Diseases Research and Treatment
- Plant Virus Research Studies
- Vibrio bacteria research studies
- Child Nutrition and Water Access
- vaccines and immunoinformatics approaches
- Genetic diversity and population structure
- COVID-19 epidemiological studies
- Family Support in Illness
- HIV Research and Treatment
- Evolution and Genetic Dynamics
- Livestock and Poultry Management
- Vaccine Coverage and Hesitancy
- Trypanosoma species research and implications
University of Ghana
2016-2025
Korle Bu Teaching Hospital
2018-2025
Kenyatta University
2024
Kenya Medical Research Institute
2006-2024
Lee University
2024
University of California, Irvine
2024
Monash University
2020
MRC Unit the Gambia
2020
Jaramogi Oginga Odinga University of Science and Technology
2012
Kwame Nkrumah University of Science and Technology
2003-2007
Land use changes have been suggested as one of the causes for malaria epidemics in African highlands. This study investigated effects deforestation-induced indoor temperature on survivorship and reproductive fitness Anopheles gambiae an epidemic prone area western Kenya We found that mean temperatures houses located deforested were 1.2°C higher than forested during dry season 0.7°C rainy season. The mosquito mortality rate was highly age-dependent regardless site or Mosquitoes placed showed...
Studies were carried out at a malaria epidemic-prone highland site in western Kenya to determine the effects of deforestation-caused microclimate change on duration gonotrophic cycle vector Anopheles gambiae Giles. Gonotrophic was measured using field-collected F1A. females. Average ambient temperature deforested area Kakamega (elevation 1,430–1,580 m above sea level), Kenya, 0.5°C higher than that forested over 10-mo period. During dry season, areas showed an increased mean indoor 1.8°C,...
Abstract We investigated the effects of deforestation on microclimates and sporogonic development Plasmodium falciparum parasites in Anopheles gambiae mosquitoes an area western Kenyan highland prone to malaria epidemics. An. were fed with P. falciparum–infected blood through membrane feeders. Fed placed houses forested deforested areas a (1,500 m above sea level) monitored for parasite development. Deforested sites had higher temperatures relative humidities, overall infection rate was...
Transmission of malaria in an area hypoendemicity the highlands western Kenya is not expected to lead rapid acquisition immunity malaria. However, subpopulation individuals with asymptomatic Plasmodium falciparum infection may play a significant role as reservoir and should be considered malaria-control programs. Determination spatiotemporal dynamics subpopulations provides opportunity estimate epidemiological importance this group transmission.Monthly parasitological surveys were undertaken...
In high-elevation areas in western Kenya, the abundance of Anopheles arabiensis is either very low or absent. The Kenya highlands (an area with an elevation > 1,500m above sea level) have also been experiencing extensive deforestation, and deforestation has suggested as one important factors that facilitate malaria transmission highlands. This study investigated whether climate conditions (Kakamega, 1,500 m were permissive to development survival An. promoted survivorship immature adult...
Abstract Horizontal gene transfer from viruses to eukaryotic cells is a pervasive phenomenon. Somatic viral integrations are linked persistent infection whereas into germline maintained in host genomes by vertical transmission and may be co‐opted for functions. In the arboviral vector Aedes aegypti , an endogenous element nonretroviral RNA virus (nrEVE) was shown produce PIWI‐interacting RNAs (piRNAs) limit with cognate virus. Thus, nrEVEs constitute heritable, sequence‐specific mechanism...
Understanding the ecology of larval malaria and lymphatic filariasis mosquitoes in a changing environment is important developing effective control tools or programmes. This study characterized breeding habitats Anopheles rural communities different ecological zones Ghana during dry rainy seasons.The spatio-temporal distribution, species composition, abundance were studied five locations three Ghana. These Anyakpor (coastal savannah area), Duase (forest Libga, Pagaza, Kpalsogu (Sahel area)....
The invasive Anopheles stephensi mosquito has rapidly expanded in range Africa over the past decade. Consistent with World Health Organization guidelines, routine entomologic surveillance of malaria vectors Accra, Ghana, now includes morphologic and molecular An. mosquitoes. We report detection mosquitoes Ghana.
Understanding the complex heterogeneity of risk factors that can contribute to an increased malaria at individual and household level will enable more effective use control measures. The objective this study was understand influence clinical infection among individuals in highlands Western Kenya.This a matched case-control undertaken Kenya highlands. Clinical cases were recruited from health facilities asymptomatic community who served as controls. Each participant screened for using...
Background Understanding the interactions between increased insecticide resistance and resting behaviour patterns of malaria mosquitoes is important for planning adequate vector control. This study was designed to investigate behavior, host preference rates Plasmodium falciparum infection in relation vectors different ecologies western Kenya. Methods Anopheles mosquito collections were carried out during dry rainy seasons Kisian (lowland site) Bungoma (highland site), both Kenya using...
The directional selection for insecticide resistance due to indiscriminate use of insecticides in public health and agricultural system favors an increase the frequency insecticide-resistant alleles natural populations. Similarly, removal pressure generally leads decay resistance. Past investigations on emergence mosquitoes mostly relied field survey vector populations that typically had a complex history exposure various pest control nature, thus effect specific rate emergency or is not...
Abstract Background Outbreaks of Aedes -borne arboviral diseases are becoming rampant in Africa. In Ghana, there is no organized control programme with interventions restricted to mitigate outbreaks. Insecticide application a crucial part outbreak responses and future preventative measures. Thus, knowledge the resistance status underlying mechanisms populations required ensure optimal insecticide choices. The present study assessed aegypti from southern Ghana (Accra, Tema Ada Foah) northern...
In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. bacteria Plasmodium or berghei falciparum). Here, data are presented from the first study response genetic diversity within a parasite species. independent field laboratory studies, measure was compared mosquitoes fed on blood that free P. falciparum...
Abstract A thorough understanding of malaria vector species composition and their bionomic characteristics is crucial to devise effective efficient control interventions reduce transmission. It has been well documented in Africa that the past decade have resulted major changes from endophilic Anopheles gambiae exophilic An. arabiensis . However, role cryptic rare mosquito transmission not known. This study examined distribution, with a particular focus on potential novel, uncharacterized...
Abstract Surveillance of malaria vector species and the monitoring insecticide resistance are essential to inform control strategies support reduction infections disease. Genetic barcoding mosquitoes is a useful tool assist high-throughput surveillance resistance, discriminate between sibling detect presence Plasmodium infections. In this study, we combined multiplex PCR, custom designed dual indexing, Illumina next generation sequencing for high throughput single nucleotide polymorphism...
The present study examined the genetic diversity and population structure of Plasmodium falciparum in western Kenya by analyzing polymorphism 12 microsatellite loci two antigen loci. Malaria highland areas is unstable epidemic whereas malaria lowland endemic. Transmission intensity prevalence are substantially lower highlands than lowlands. Despite that parasite populations exhibited reduced number alleles, expected heterozygosity, infection complexity comparison to surrounding population,...
Irrigated vegetable farms within the city of Kumasi, Ghana, create hotspots for breeding malaria vectors, which could lead to high transmission malaria. This study investigated abundance and productivity mosquitoes in an irrigated farm Ghana.Adult mosquito was estimated five days a week different scheme types (dug-out wells, furrows footprints) 12 weeks using emergence traps. Larval sampling done estimate larvae from schemes types.Mosquito field confined dug-out human footprints. Mosquito...
Background Long Lasting Insecticidal Nets (LLINs) and indoor residual spraying (IRS) represent powerful tools for controlling malaria vectors in sub-Saharan Africa. The success of these interventions relies on their capability to inhibit feeding resting mosquitoes. This study sought understand the interaction insecticide resistance with outdoor behavioral responses from Western Kenya. Methods status among anopheline mosquitoes was compared Anopheles collected Kisumu Bungoma counties level...
Vector control is the main intervention used to arboviral diseases transmitted by Aedes mosquitoes because there are no effective vaccines or treatments for most of them. Control relies heavily on use insecticides, effectiveness which may be impacted resistance. In addition, rational insecticide application requires detailed knowledge vector distribution, dynamics, resting, and feeding behaviours, poorly understood in Africa. This study investigated spatiotemporal distribution resistance...
<ns3:p>Background<ns3:italic>Culex (Cx.) tritaeniorhynchus</ns3:italic>is an invasive mosquito species with extensive and expanding inter-continental distribution, currently reported across Asia, Africa, the Middle East, Europe now Australia. It is important vector of medical veterinary pathogens which cause significant morbidity mortality in human animal populations. Across regions endemic for Japanese encephalitis virus (JEV),<ns3:italic>Cx. considered major has also been shown to...
Abstract Background Despite increasing documentation of insecticide resistance in malaria vectors against public health insecticides sub-Saharan Africa, there is a paucity information on the potential fitness costs pyrethroid vectors, which important improving current resistant management strategies. This study aimed to assess cost effects development and survival immature Anopheles gambiae from western Kenya. Methods Two-hour old, first instar larvae (L1) were introduced raised basins...