A5057660696- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Protein Tyrosine Phosphatases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vehicle emissions and performance
- Maritime Transport Emissions and Efficiency
- Air Quality and Health Impacts
- Redox biology and oxidative stress
- Coenzyme Q10 studies and effects
- Bioactive Compounds and Antitumor Agents
- Vitamin C and Antioxidants Research
- Sulfur Compounds in Biology
- Lymphoma Diagnosis and Treatment
- RFID technology advancements
- Biodiesel Production and Applications
- Effects of Radiation Exposure
- Electron Spin Resonance Studies
- Viral-associated cancers and disorders
- Atmospheric chemistry and aerosols
- Modular Robots and Swarm Intelligence
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
- Antenna Design and Analysis
- Radiation Therapy and Dosimetry
Winship Cancer Institute
2025
Piedmont Cancer Institute
2025
Emory University
2023-2024
Gunma University
2024
University of Tsukuba
2015-2022
Hue University
2019-2022
Vietnam Maritime University
2018-2019
Thioredoxin system–mediated persulfidation of Cys residues controls protein function and protects them from oxidative stress.
Abstract DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) response to ionizing radiation (IR) govern genome integrity. The interaction of catalytic subunit DNA-PK (DNA-PKcs) with Ku70/Ku80 heterodimer on DSBs leads activation; however, it is not known if upstream signaling events this activation. Here, we reveal regulatory step governing activation by SIRT2 deacetylation,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) has one of the highest cancer mortality rates with a 5-year survival rate only 12% despite tumor removal and/or chemo-radiotherapy. The poor prognosis is partly due to therapy resistance driven by genes and pathways regulating cell signaling, proliferation, metastasis. DNA damage response (DDR) contribute this enabling cells repair treatment-induced damage, evade apoptosis, adapt through alternative mechanisms, emphasizing need for new...
In this study, emission factors of both particle and gaseous phases are characterised on board two large cargo vessels operating the east coast Australia during manoeuvring conditions. order to investigate difference in number mass size distributions, measurements were conducted 2-stroke engines using Heavy Fuel Oil (HFO) with nearly same sulphur content. Results showed that compared ocean-going conditions resulted higher for carbon monoxide (CO), dioxide (CO2), unburnt hydrocarbon (HC),...
Purpose Radiation-induced bystander effect (RIBE) frequently is seen as DNA damage in unirradiated cells, but the repair processes initiated response to that are not well understood. RIBE-mediated formation of micronuclei (MN), a biomarker persistent damage, was previously observed normal fibroblast (AG01522) human chondrosarcoma (HTB94) cells. The molecular mechanisms causing this disparity clear. Herein, we investigate role responses two cell lines.
Recently, we established a biotin-PEAC5-maleimide (BPM)-labeling assay, which can be used to determine the modification of electrophilic metals proteins (Toyama et al., J. Toxicol. Sci., 38, 477-484, 2013). In present study, applied BPM-labeling assay detect protein S-modification by environmental organic electrophiles. After exposing A431 cells 1,2-naphthoquinone (1,2-NQ) and 1,4-naphthoquinone (1,4-NQ), there was an inverse correlation between Western blot analysis with specific antibody...
We previously reported that 9,10-phenanthraquinone (9,10-PQ), an atmospheric electron acceptor, undergoes redox cycling with dithiols as donors, resulting in the formation of semiquinone radicals and monothiyl radicals; however, monothiols have little reactivity. Because persulfide polysulfide species are highly reducing, we speculate 9,10-PQ might undergo one-electron reduction these reactive sulfides. In present study, explored capability a variety quinone-related acceptors, including...
9,10-Phenanthrenequinone (9,10-PQ) is a polycyclic aromatic hydrocarbon quinone contaminated in diesel exhaust particles and particulate matter 2.5. It an efficient electron acceptor that induces redox cycling with donors, resulting excessive reactive oxygen species oxidized protein production cells. The current study examined whether 9,10-PQ could activate epidermal growth factor receptor (EGFR) signaling A431 cells through S-oxidation of its negative regulators such as tyrosine phosphatase...
Abstract Diffuse large B-cell lymphoma (DLBCL) is a commonly diagnosed, aggressive non-Hodgkin's lymphoma. While R-CHOP chemoimmunotherapy potentially curative, about 40% of DLBCL patients will fail, highlighting the need to identify biomarkers optimize management. SAMHD1 has dNTPase-independent role in promoting resection facilitate DNA double-strand break (DSB) repair by homologous recombination. We evaluated relationship levels with sensitivity DSB-sensitizing agents cells and association...
In this paper, a small analysis was carried out on the various design of radio frequency labels used today. Using program for electrodynamic modeling HFSS, effect air gap variation analyzed, because cargo containers have not only flat surface, but also corrugated one. Therefore, conventional traditional microstrip antenna with different filling, between screen and cloth, investigated.
[Page 358, Figure 5C] The label of Western blot data in 5C the paper was erroneously placed.
Redox-active quinones generate reactive oxygen species (ROS) through their redox cycling with electron donors. Hydrogen peroxide (H2O2) causes S-oxidation of proteins and is associated activation the signaling pathway and/or toxicity (Chem. Res. Toxicol., 30, 2017, Kumagai et al.). In present study, we developed a convenient assay based on combination an enzyme-linked immunosorbent biotin-PEAC5-maleimide used it to determine protein by ROS during 9,10-phenanthrenequinone (9,10-PQ)...
9,10-Phenanthrenequinone (9,10-PQ) is a toxicant in diesel exhaust particles and airborne particulate matter ≤2.5 μm diameter. It an efficient electron acceptor that readily reacts with dithiol compounds vitro, resulting the oxidation of thiol groups concomitant generation reactive oxygen species (ROS). However, it remains to be elucidated whether 9,10-PQ interacts proximal protein dithiols. In present study, we used thioredoxin 1 (Trx1) as model proteins cysteines examined cells tissues,...