A5026909301- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Effects of Radiation Exposure
- Cellular Mechanics and Interactions
- Glioma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Electron Spin Resonance Studies
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Multiple Myeloma Research and Treatments
- Autophagy in Disease and Therapy
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
University of Patras
2011-2023
Cornell University
2014
General University Hospital of Patras
2008-2013
University of Peloponnese
2008
Background/Aim: Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critically implicated in metastasis chemoresistance. Herein, we investigated integrin-linked kinase (ILK)9s role human colon (CRC) progression chemoresistance relation to EMT CSC markers. Patients Methods: Expression of ILK, markers were evaluated by immunohistochemistry 149 CRC samples. We also generated resistant 5-FU oxaliplatin studied the effect ILK inhibition on drug response MTT assay markers9...
Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects tumor cells from complement system attack. In the present study, we show for first time in situ expression of serglycin breast cancer immunohistochemistry patients' material. Moreover, demonstrate high constitutive secretion aggressive MDA-MB-231 cell line. exhibited strong cytoplasmic staining these cells, observable at periphery thread filaments near membrane, but also filopodia-like...
Pleiotrophin (PTN) is a heparin-binding growth factor with significant role(s) in tumour and angiogenesis. Although implication of endogenous PTN has been studied several vivo models angiogenesis, its role physiological angiogenesis not addressed. In the present work, we expression functional significance during chicken embryo chorioallantoic membrane (CAM).Using molecular, cellular biochemical assays, pattern CAM human endothelial cells possible interaction nucleolin (NCL). were transfected...
X-rays have an antiangiogenic effect in the chicken embryo chorioallantoic membrane (CAM) model of vivo angiogenesis. Our study demonstrates that induce early apoptosis CAM cells, modulate synthesis and deposition extracellular matrix (ECM) proteins involved regulating angiogenesis affect induced by tumour cells implanted onto CAM. Apoptosis was evident within 1–2 hr, but not later than 6 hr after irradiation. Fibronectin, laminin, collagen type I, integrin αvβ3 MMP-2 protein amounts were...
Breast cancer is the leading cause of deaths for women worldwide. Endocrine therapies represent cornerstone hormone-dependent breast treatment. However, in many cases, endocrine resistance induced with poor prognosis patients. In current study, we have developed MCF-7 cell lines resistant to fulvestrant (MCF-7Fulv) and tamoxifen (MCF-7Tam) aiming at investigating mechanisms underlying resistance. Both exerted lower proliferation capacity two-dimensional (2-D) cultures but retain estrogen...
Recent evidence suggests that estrogen signaling may be involved in the pathogenesis of non-small cell lung cancer (NSCLC). Aromatase is an enzyme complex catalyses final step synthesis and present several tissues, including lung. In current study we investigated activity aromatase inhibitor exemestane human NSCLC lines H23 A549. expression was detected both lines. cells showed lower protein mRNA levels aromatase, compared to A549 cells. Exemestane decreased proliferation increased apoptosis...
Radiation exerts direct as well indirect effects on DNA through the generation of reactive oxygen species (ROS). Irradiated hematopoietic progenitor cells (HPCs) experience strand breaks, favoring genetic instability, due to ROS generation. Our aim was study effect a range radiation doses in HPCs and possible protective mechanisms activated by insulin-like growth factor-1 (IGF-1). evaluated, presence or absence IGF-1 liquid cultures human HPCs-CD34+ irradiated with 1-, 2- 5-Gy X-rays, using...
There is no doubt that there are increased benefits of hormonal therapy to breast cancer patients; however, current evidence suggests estrogen receptor (ER) blockage using antiestrogens associated with a small induction invasiveness in vitro. The mechanism by which epithelial tumor cells escape from the primary and colonize distant site not entirely understood. This study investigates effect two selective antagonists ER, Fulvestrant (Fulv) Tamoxifen (Tam), on invasive ability cells. We found...
This study aims to address the role of focal adhesion proteins α- and β-parvin in human colorectal carcinoma (CRC). Expression was examined by immunohisto- chemistry real-time RT-PCR a series CRC. Parvins were overexpressed CRC their expression correlated significantly with tumor invasion, lymph node metastasis, disease stage. A significant positive correlation parvins protein overexpression integrin-linked kinase, p-AKT, nuclear β-catenin, as well downregulation E-cadherin also observed. In...
Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. receptor undergoes cleavage by enzymes, including γ-secretase, generating the active intracellular domain (NICD). The aim of present study was to investigate effect DAPT, γ-secretase inhibitor, non-small cell (NSCLC) cells, well impact epidermal growth factor (EGF) that is over-expressed NSCLC on signaling. H23, A549, H661 and HCC827 human lines were used, expressing various NICD EGF (EGFR) protein levels. DAPT...