A5020809971- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cytokine Signaling Pathways and Interactions
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
- Histone Deacetylase Inhibitors Research
- Endometriosis Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Advances in Oncology and Radiotherapy
- Genomics, phytochemicals, and oxidative stress
- Multiple Myeloma Research and Treatments
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
Fiona Stanley Hospital
2025
Curtin University
2025
scPharmaceuticals (United States)
2025
Army Medical University
2025
Daping Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
University of California, Los Angeles
2020-2024
Sichuan Provincial Architectural Design and Research Institute (China)
2024
Jinshan Hospital of Fudan University
2024
UCLA Medical Center
2022
Background The comparative risks of a second cancer diagnosis are uncertain after primary treatment with 3‐dimensional conformal radiotherapy (3DCRT), intensity‐modulated (IMRT), or proton beam (PBRT). Methods Pediatric and adult patients first between 2004 2015 who received 3DCRT, IMRT, PBRT were identified in the National Cancer Database from 9 tumor types: head neck, gastrointestinal, gynecologic, lymphoma, lung, prostate, breast, bone/soft tissue, brain/central nervous system. was...
An epigenetic modification prevents the production of a tumor-suppressing and anti-inflammatory microRNA in receptor-negative breast cancers.
The Wilms' tumor suppressor 1 (WT1) gene encodes a DNA- and RNA-binding protein that plays an essential role in nephron progenitor differentiation during renal development. To identify WT1 target genes might regulate vivo, we performed chromatin immunoprecipitation (ChIP) coupled to mouse promoter microarray (ChIP-chip) using prepared from embryonic kidney tissue. We identified 1663 bound by WT1, 86% of which contain previously identified, conserved, high-affinity binding site. investigate...
Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations mutations with outcome. Here, we analyze 232 consecutive patients NSCLC and demonstrate that KEAP1 NFE2L2 are predictive high rates local recurrence (LR) after radiotherapy but surgery. Half LRs occurred tumors KEAP1/NFE2L2 mutations, indicating they major molecular drivers clinical radioresistance. Next, functionally evaluate our cohort only pathogenic associated...
Activation of the transcription factor STAT5 is essential for pathogenesis acute myelogenous leukemia (AML) containing FLT3 internal tandem duplication (ITD) mutation. ITD a constitutively active tyrosine kinase that drives activation STAT5, leading to growth and survival AML cells. Although there has been some success in identifying inhibitors block function ITD, remains continued need effective treatment this disease. We have identified psychotropic drug pimozide as an inhibitor function....
Abstract The transcription factor signal STAT5 is constitutively activated in a wide range of leukemias and lymphomas, drives the expression genes necessary for proliferation, survival, self-renewal. Thus, targeting an appealing therapeutic strategy hematologic malignancies. Given importance bromodomain-containing proteins transcriptional regulation, we considered hypothesis that pharmacologic bromodomain inhibitor could inhibit STAT5-dependent gene expression. We found small-molecule...
Atovaquone, a US Food and Drug Administration-approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well tolerated, plasma concentrations of 40 80 µM have been achieved with pediatric adult dosing. We conducted preclinical testing atovaquone acute myeloid leukemia (AML) cell lines patient samples. Atovaquone induced apoptosis an EC50 <30 for most AML primary specimens. In NSG mice xenografted luciferase-expressing THP-1 cells those...
<h3>Importance</h3> Radiotherapy combined with androgen deprivation therapy (ADT) is a standard of care for high-risk prostate cancer. However, the interplay between radiotherapy dose and required minimum duration ADT uncertain. <h3>Objective</h3> To determine specific threshold that provides distant metastasis-free survival (DMFS) benefit in patients cancer receiving external beam (EBRT) or EBRT brachytherapy boost (EBRT+BT). <h3>Design, Settings, Participants</h3> This was cohort study 3...
Background Anemia represents a significant global health issue affecting numerous children and women, characterized by diminished hemoglobin levels that may impede cognitive developmental progress. Although commonly attributed to iron deficiency, the etiology of anemia in this demographic is multifaceted, encompassing nutritional, genetic, infectious contributors. Nonetheless, there lack high-quality data on prevalence causes analysis among under 5 years. The aim study was provide...
Gene Ontology (GO) has been widely used to infer functional significance associated with sets of genes in order automate discoveries within large-scale genetic studies. A level GO's direct acyclic graph structure is often assumed be indicative its terms' specificities, although other work suggested this assumption does not hold. Unfortunately, quantitative analysis biological functions based on nodes at the same (as common gene enrichment tools) can lead incorrect conclusions as well missed...
Background Cisplatin and cetuximab are both systemic therapies commonly used in combination with radiation (RT) for the definitive treatment of head neck cancers, but their comparative efficacy is unclear. Methods Patients locoregionally advanced (American Joint Committee on Cancer stage III‐IVB) squamous cell carcinomas oropharynx, larynx, or hypopharynx were identified Surveillance, Epidemiology, End Results‐Medicare database. received either cisplatin concurrent RT, as determined by...
<h3>Importance</h3> Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) can detect low-volume, nonlocalized (ie, regional or metastatic) prostate cancer that was occult on conventional imaging. However, the long-term clinical implications of PSMA PET/CT upstaging remain unclear. <h3>Objectives</h3> To evaluate prognostic significance a nomogram models an individual’s risk and to compare its performance with existing risk-stratification tools....
Activating mutations in the Tyrosine kinase FLT3 occur about 25% of acute myeloid leukemias (AML)1 and selective inhibitors are clinically effective have been recently approved by FDA for patients with relapsed/refractory AML mutations. While effective, a significant challenge current is rapid development resistance through mechanisms including additional mutations, CYP3A4 upregulation, or adaptive activation parallel signaling pathways. It has shown that an important mechanism to involves...