A5023942285- Cytokine Signaling Pathways and Interactions
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Tuberculosis Research and Epidemiology
- Geographic Information Systems Studies
- Inflammatory Bowel Disease
- Microtubule and mitosis dynamics
- NF-κB Signaling Pathways
- Autoimmune and Inflammatory Disorders
- Immunotherapy and Immune Responses
- Hidradenitis Suppurativa and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Intestinal Malrotation and Obstruction Disorders
- Drug-Induced Adverse Reactions
- Microscopic Colitis
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Cancer and Skin Lesions
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Nonmelanoma Skin Cancer Studies
Stanford University
2022-2025
Brigham and Women's Hospital
2013-2022
Massachusetts General Hospital
2019-2022
Harvard University
2013-2021
Harvard Affiliated Emergency Medicine Residency
2020-2021
Dana-Farber Cancer Institute
2013-2021
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
Texas Children's Hospital
2020
Baylor College of Medicine
2020
Abstract Different classes of biotic (e.g. plant hormones) and abiotic different wavelengths light) signals act through specific signal transduction mechanisms to coordinate higher development. While a great deal progress has been made, full chains have not yet described for most blue light- or abscisic acid-mediated events. Based on data derived from T-DNA insertion mutants yeast (Saccharomyces cerevisiae) two-hybrid coprecipitation assays, we report chain shared by light acid leading...
An epigenetic modification prevents the production of a tumor-suppressing and anti-inflammatory microRNA in receptor-negative breast cancers.
Inappropriate activation of the transcription factors STAT3 and STAT5 has been shown to drive cancer pathogenesis through dysregulation genes involved in cell survival, growth, differentiation. Although are structurally related, they can have opposite effects on key genes, including BCL6. BCL6, a transcriptional repressor, be oncogenic diffuse large B lymphoma. BCL6 also plays an important role breast pathogenesis, disease which activated individually or concomitantly. To determine mechanism...
The transcription factor STAT3 is activated inappropriately in 70% of breast cancers, most commonly triple negative cancer (TNBC). Although the transcriptional function essential for tumorigenesis, key target genes regulated by driving tumor pathogenesis have remained unclear. To identify critical genes, we treated TNBC cell lines with two different compounds that block function, pyrimethamine and PMPTP. We then performed gene expression analysis to whose strongly down-regulated both...
Maturation of dendritic cells (DCs) is required to induce T cell immunity, whereas immature DCs can immune tolerance. Although the transcription factor STAT5 suggested participate in DC maturation, its role this process remains unclear. In study, we investigated effect inhibition on LPS-induced maturation human monocyte-derived (Mo-DCs). We inhibited by treating Mo-DCs with JQ1, a selective inhibitor BET epigenetic readers, which suppress function. found that JQ1 inhibits phosphorylation and...
The transcription factor STAT3 is constitutively active in many cancers, where it mediates important biological effects, including cell proliferation, differentiation, survival, and angiogenesis. N-terminal domain (NTD) of performs multiple functions, such as cooperative DNA binding, nuclear translocation, protein-protein interactions. However, unclear which subsets target genes depend on the NTD for transcriptional regulation. To identify genes, we compared gene expression STAT3-null mouse...
Cancer is often characterized by aberrant gene expression patterns caused the inappropriate activation of transcription factors. Signal transducer and activator 3 (STAT3) a key transcriptional regulator many protumorigenic processes persistently activated in types human cancer. However, like factors, STAT3 has proven difficult to target clinically. To address this unmet clinical need, we previously developed cell-based assay activity performed an unbiased high-throughput screen small...
// Patricia A. Toniolo 1, 2 , Suhu Liu 1 Jennifer E. Yeh Darwin Q. Ye José Alexandre M. Barbuto David Frank Department of Medical Oncology, Dana-Farber Cancer Institute, and Medicine, Brigham Women's Hospital Harvard School, Boston, MA, USA Immunology, Institute Biomedical Sciences, University Sao Paulo, Brazil Correspondence to: Frank, email: david_frank@dfci.harvard.edu Keywords: monocytes, dendritic cells, SOCS5, CLL, STAT3 Received: December 01, 2015 Accepted: May 28, 2016 Published:...
Introduction: Systemic lupus erythematosus (SLE) patient hospitalizations were areas of concern during the coronavirus 2019 (COVID-19) and subsequent vaccine rollout. We aimed to characterize hospitalization trends nationally amongst SLE patients following COVID-19 Methods: The 2016-2020 Nationwide Inpatient Sample (NIS) was queried for using International Classification Diseases, Tenth Revision (ICD-10) code “M32”. with co-morbid reactions (RX+) identified ICD-10 codes “T50.x”. Clinical...
ABSTRACT Differences in cellular competence offer an explanation for the differences healing capacity of tissues various ages and conditions. The homeobox family genes plays key roles governing competence. Of these, we hypothesize that Msx2 is a strong candidate regulator skin wound because it expressed during fetal development stage scarless healing, affects postnatal digit regeneration, reexpressed transiently repair. To address whether injury repair, 3 mm full‐thickness excisional wounds...
Since the neoplastic phenotype of a cell is largely driven by aberrant gene expression patterns, increasing attention has been focused on transcription factors that regulate critical mediators tumorigenesis such as signal transducer and activator 3 (STAT3). As proteins interact with STAT3 may be key in addressing how contributes to cancer pathogenesis, we took proteomics approach identify novel STAT3-interacting proteins. We performed mass spectrometry-based profiling STAT3-containing...
ABSTRACT Background: Biliary atresia's (BA) response to surgical Kasai portoenterostomy (KP) is uneven and dependent upon bile flow; 50% of infants require a liver transplant by 24 months. We hypothesized that the microbiome may identify associate with outcomes in BA. Methods: Stool samples were collected from cholestasis (n = 15), 8 which BA followed longitudinally.16S sequencing was performed on all 45). Whole Genome Sequencing (WGS) pre‐KP 8). Infants BA, other forms cholestasis, very...
Chronic skin ulcers in patients with suspected pyoderma gangrenosum can, on closer inspection and further workup, have a different cause. Recognition of key features clinical examination such as the presence atrophie blanche is to avoid misdiagnosis its subsequent treatment high-dose corticosteroids other immunosuppressive medications.
Abstract Cancers that develop in BRCA1 mutation carriers are usually near tetraploid/polyploid. This led us to hypothesize controls the mitotic checkpoint complex, as loss of such control could lead errors resulting tetraploidy/polyploidy and subsequent aneuploidy. We used an vitro system mimicking premalignant conditions, consisting cell strains derived from benign counterparts serous ovarian carcinomas (cystadenomas) expressing SV40 large T antigen, conferring equivalent a p53 mutation....
Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases.We performed high-throughput sequencing of mouse livers with diverse types injuries, including cholestasis, diet-induced steatosis, partial hepatectomy. Comparative analysis transcriptome from mice human samples viral infections (HBV HCV), alcoholic hepatitis (AH), non-alcoholic steatohepatitis (NASH), biliary...
A recent article published by Britschgi et al. in Cancer Cell, "JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: Rationale for Cotargeting These Pathways Metastatic Breast Cancer," describes a positive feedback loop of JAK2/STAT5 activation that drives resistance inhibition breast cancer. The authors found genetic or pharmacological JAK2 circumvents and go on show the efficacy combined reducing cancer cell number, tumor growth, metastasis as well increasing vivo survival....