A5075740763- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Management of metastatic bone disease
- Economic and Financial Impacts of Cancer
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Musicology and Musical Analysis
- History and Developments in Astronomy
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Effects of Radiation Exposure
- Urologic and reproductive health conditions
University of California, Los Angeles
2016-2025
UCLA Jonsson Comprehensive Cancer Center
2011-2024
UCLA Health
2020-2024
Cancer Treatment Centers of America
2023
Olive View-UCLA Medical Center
2023
Migration Institute of Australia
2022
UCLA Medical Center
2012-2021
Los Angeles Medical Center
2021
University of California, San Francisco
2020
Memorial Hospital of South Bend
2020
The effectiveness of stereotactic body radiotherapy (SBRT) for localized prostate cancer is tested.A total 1100 patients with clinically were enrolled in separate prospective phase 2 clinical trials SBRT from 8 institutions during 2003-11 and pooled analysis. using the CyberKnife delivered a median dose 36.25Gy 4-5 fractions. Patients low-risk (58%), intermediate-risk (30%) high-risk (11%). A short-course androgen deprivation therapy (ADT) was given to 14%. PSA relapse defined as rise...
<h3>Importance</h3> The optimal treatment for Gleason score 9-10 prostate cancer is unknown. <h3>Objective</h3> To compare clinical outcomes of patients with after definitive treatment. <h3>Design, Setting, and Participants</h3> Retrospective cohort study in 12 tertiary centers (11 the United States, 1 Norway), 1809 treated between 2000 2013. <h3>Exposures</h3> Radical prostatectomy (RP), external beam radiotherapy (EBRT) androgen deprivation therapy, or EBRT plus brachytherapy boost...
Stereotactic body radiotherapy harnesses improvements in technology to allow the completion of a course external beam treatment for prostate cancer span 4 5 sessions. Although mounting short-term data support this approach, long-term outcomes have been sparsely reported.To assess after stereotactic low-risk and intermediate-risk cancer.This cohort study analyzed individual patient from 2142 men enrolled 10 single-institution phase 2 trials multi-institutional between January 1, 2000,...
Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. <sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA-11) PET/CT detects PCa with sensitivity superior to standard-of-care imaging at serum (PSA) values low enough affect target routine SRT. Our objective was map recurrence pattern early biochemical (BCR) <sup>68</sup>Ga-PSMA-11 patients PSA levels less than 1...
Magnetic resonance imaging (MRI) guidance offers multiple theoretical advantages in the context of stereotactic body radiotherapy (SBRT) for prostate cancer. However, to our knowledge, these have yet be demonstrated a randomized clinical trial.
Importance Hypofractionated radiation therapy (RT) for prostate cancer has been associated with greater acute grade 2 gastrointestinal (GI) toxic effects compared conventionally fractionated RT. Objective To evaluate whether a hyaluronic acid rectal spacer could (1) improve dosimetry and (2) affect or higher GI hypofractionated Design, Setting, Participants This randomized clinical trial was conducted from March 2020 to June 2021 among 12 centers within the US, Australia, Spain, 6-month...
To evaluate the early and late health-related quality of life (QOL) outcomes among prostate cancer patients following stereotactic body radiation therapy (SBRT).Patient self-reported QOL was prospectively measured 864 from phase 2 clinical trials SBRT for localized cancer. Data Expanded Prostate Cancer Index Composite (EPIC) instrument were obtained at baseline regular intervals up to 6 years. delivered a median dose 36.25 Gy in 4 or 5 fractions. A short course androgen deprivation given 14%...
Given the costs of delivering care for men with prostate cancer remain poorly described, this article reports results time-driven activity-based costing (TDABC) competing treatments low-risk cancer. Process maps were developed each phase from initial urologic visit through 12 years follow-up robotic-assisted laparoscopic prostatectomy (RALP), cryotherapy, high-dose rate (HDR) and low-dose (LDR) brachytherapy, intensity-modulated radiation therapy (IMRT), stereotactic body (SBRT), active...
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers the world. This technology has facilitated clinical implementation of online adaptive (OART), or ability to alter daily treatment plan based on tumor and anatomical changes real-time while patient table. However, due time sensitive nature OART, a large busy clinic many potential obstacles as well patient-related safety considerations. In this work, we have described new process care...
Standard-of-care imaging for initial staging of prostate cancer (PCa) underestimates disease burden. Prostate-specific membrane antigen (PSMA) PET/CT detects PCa metastasis with superior accuracy, having a potential impact on the planning definitive radiation therapy (RT) nonmetastatic PCa. Our objectives were to determine how often RT based standard target volumes covers <sup>68</sup>Ga-PSMA-11 PET/CT–defined and assess planning. <b>Methods:</b> This was post hoc analysis an...
In a single-institution phase II study, we evaluated the safety of 5-day dose-equivalent neoadjuvant radiotherapy (RT) regimen for high-risk primary soft tissue sarcoma.Patients received RT alone (30 Gy in five fractions) to tumor with standard margins. The endpoint was grade ≥2 late-radiation toxicity. Major wound complications, local recurrences, and distant metastases were also examined. exploratory analysis, germline biomarkers toxicity effects study on treatment utilization.Over 2...
Abstract BACKGROUND. Disparities in cancer detection, treatment, and outcomes among racial/ethnic minorities low‐income patients are well documented. One way to reduce these disparities is use patient navigators address barriers care. However, little information about optimal characteristics of navigator programs or considerations for those interested setting up such available. METHODS. The design implementation a program underserved an urban, nonacademic community hospital described....