A5103235942- Vitamin D Research Studies
- Birth, Development, and Health
- Bone health and osteoporosis research
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Bone health and treatments
- Connective tissue disorders research
- Vitamin C and Antioxidants Research
- Body Composition Measurement Techniques
- Bone fractures and treatments
- Pulmonary Hypertension Research and Treatments
- Urological Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Growth Hormone and Insulin-like Growth Factors
- Health Systems, Economic Evaluations, Quality of Life
- Immune Response and Inflammation
- Gestational Diabetes Research and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Pancreatic function and diabetes
- Per- and polyfluoroalkyl substances research
Smt. N.H.L. Municipal Medical College
2023
University of Sheffield
2006-2022
National Health Service
2017-2022
Bispebjerg Hospital
2021
St Mary's Hospital
2021
Manipal Hospital
2020
Toronto Public Health
2012-2018
Canadian Sleep Society
2018
Sheffield Teaching Hospitals NHS Foundation Trust
2006-2017
Royal Hallamshire Hospital
2008-2017
Maternal vitamin D status has been associated with bone mass of offspring in many, but not all, observational studies. However, maternal repletion during pregnancy yet proven to improve a randomised controlled trial. We aimed assess whether neonates born mothers supplemented have greater whole-body mineral content (BMC) at birth than those who had received supplementation.The Vitamin Osteoporosis Study (MAVIDOS) was multicentre, double-blind, randomised, placebo-controlled trial that...
MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR.Osteoporosis major public health problem as result of associated fragility fractures. Skeletal strength increases from birth to peak in early adulthood. This predicts osteoporosis risk later life. Vitamin D insufficiency pregnancy common (31% recent Southampton cohort) reduced bone mass the offspring. In this study we aim...
Abstract Context Single-nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin [25(OH)D] concentration, but these relationships not examined following antenatal cholecalciferol supplementation. Objective To determine whether SNPs DHCR7, CYP2R1, CYP24A1, and GC are the response gestational Design Within-randomization group analysis of Maternal Vitamin Osteoporosis Study trial Setting Hospital clinics. Participants In total,...
Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin (25(OH)D) response.We assessed which maternal and environmental characteristics were associated with 25(OH)D after cholecalciferol.Within-randomization-group analysis of participants the Maternal Vitamin Osteoporosis Study trial pregnancy.Hospital clinics.A total 829 pregnant women (422 placebo, 407 cholecalciferol). At 14 34 weeks gestation, anthropometry, health,...
We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus RXRA offspring bone mass. In this study, we used an existing randomized trial to test hypothesis that gestational vitamin supplementation would lead reduced methylation. The Maternal Vitamin Osteoporosis Study (MAVIDOS) was a multicenter, double-blind, randomized, placebo-controlled of 1000 IU/day cholecalciferol or matched...
ABSTRACT In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin supplementation in pregnancy did not lead to greater neonatal bone mass across trial as a whole, but, prespecified secondary analysis by season of birth, led among winter‐born babies. Demonstrating persistence this effect into childhood would increase confidence long‐term benefit intervention. We investigated whether antenatal increases offspring mineralization early prespecified, single‐center...
The pattern of change in maternal bone turnover throughout pregnancy is poorly characterized. We investigated changes across a marker resorption, urinary C-terminal telopeptide type I collagen (CTX), the influence gestational vitamin D supplementation, and associations between CTX postnatal indices. MAVIDOS (the Maternal Vitamin Osteoporosis Study) randomized, double-blind, placebo-controlled trial 1000 IU cholecalciferol/d compared with placebo from 14 weeks gestation to birth. second-void...
Dandy-Walker malformation is a rare abnormality of the central nervous system (CNS) with reported incidence 1 in 25,00-35,00 live births and slight female predominance. It accounts for 1-4% cases antenatally detected hydrocephalus. Dandy Walker variant forms part spectrum malformation. characterized by partial agenesis vermis, resulting communication between fourth ventricle cisterna magna. demonstrates an enlarged posterior fossa, high insertion torcula herophili, as well other features. In...
We sought to compare uterine cervical electrical impedance spectroscopy measurements employing two probes of different sizes, and employ a finite element model predict the fraction current derived from subepithelial stromal tissue.Cervical was measured in 12 subjects during early pregnancy using 2 sizes on each subject.Mean resistivity significantly higher (5.4 vs. 2.8 Omegam; p < 0.001) with smaller probe frequency rage 4-819 kHz. There no difference short-term intra-observer variability...
Abstract Background Observational studies relating maternal 25-hydroxyvitamin D status to timing and mode of delivery have reported inconsistent results. We assessed the effect antenatal cholecalciferol supplementation on incidence preterm birth, post-partum haemorrhage (PPH). Methods MAVIDOS was a randomized, double-blind, placebo-controlled trial 1000 IU/day from 14 weeks’ gestation until delivery. Gestational age, [categorized as spontaneous vaginal (SVD), instrumental (including forceps...
Human parturition is associated with many pro-inflammatory mediators which are regulated by the nuclear factor-kappaB (NF-κB) family of transcription factors. In present study, we employed a ChIP-on-chip approach to define genomic loci within chromatin PHM1-31 myometrial cells that were occupied RelA-containing NF-κB dimers in response TNF stimulation 1 h. TNF-stimulated cells, anti-RelA serum enriched 13 300 regions; importantly, 11 110 regions also antibodies absence TNF. DNA sequences...
Objective To identify prognostic factors for the long‐term success of transcervical resection endometrium (TCRE). Design A retrospective analysis. Setting Department Obstetrics and Gynaecology, Solihull Hospital, Solihull, West Midlands, UK. Subjects 301 patients, who chose endometrial rather than hysterectomy underwent their first TCRE between 17 October 1989 31 December 1994. Interventions Endometrial carried out by one surgeon (D.W.S.). Main outcome measures Patient satisfaction, degree...
We report two cases of a fetus with megalourethra associated hypoplastic left heart, dilated and echogenic bowels, vesico-colonic fistula an imperforate anus. This combination fetal abnormalities may represent unclassified syndrome.
The onset of human parturition is associated with up-regulation pro-inflammatory cytokines including TNF as well changes in ion flux, principally Ca2+ and K+, across the myometrial myocytes membrane. Elevation intra-cellular from sarcoplasmic reticulum opens L-type channels; turn this increased calcium level activates MaxiK channels leading to relaxation. While nature how cross-talk governed remains unclear, our previous work demonstrated that cytokine, TNF, histone deacetylase inhibitor,...
Managing pregnancy in pulmonary hypertension using a multi-professional approach: 16-year experience specialist referral centre <b>Background:</b> Pulmonary (PH) is associated with high risk of maternal death (30-50%). Despite risks, patients may actively plan pregnancy. Patients also present whilst pregnant previously undiagnosed PH. <b>Methods:</b> Retrospective review presenting during at PH between 2001 and 2017. <b>Results:</b> 35 pregnancies 26 women resulted 20 live births, 8...
DAS28 score.Analyses also compared methylation levels with changes in and the individual components over six months.Results: Based on percentage change methylation, p-value (<10 À5 ), there were two DMPs identified at 4 weeks, which associated response.An additional three tender joint count, whilst other swollen a further four CRP.Conclusion: These preliminary results suggest DNA may provide useful source of biomarkers MTX response.Further analysis is being conducted significant findings are...
descriptive data on rates of total hip (THR) and knee replacement (TKR) within a large national cohort incident RA patients describe the potential influence age, sex, geographic region socio-economic status.Methods: Patients with first diagnosis between 1995 2013 were identified from Clinical Practice Research Datalink (CPRD).Those diagnoses multiple types inflammatory arthritis excluded.First occurrence subsequent primary THR TKR using validated (to hospital records) Read code lists...