A5089889708- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 diagnosis using AI
- Advanced Neuroimaging Techniques and Applications
- Lysosomal Storage Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Optical Imaging and Spectroscopy Techniques
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury Research
- Glycogen Storage Diseases and Myoclonus
- Systemic Lupus Erythematosus Research
- Fetal and Pediatric Neurological Disorders
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neonatal Respiratory Health Research
- Laser Applications in Dentistry and Medicine
- Whipple's Disease and Interleukins
- Autoimmune and Inflammatory Disorders Research
- Cerebrospinal fluid and hydrocephalus
Athinoula A. Martinos Center for Biomedical Imaging
2020-2024
University of California, Irvine
2024
Pennsylvania State University
2024
University of Pennsylvania
2024
Massachusetts General Hospital
2017-2024
Harvard University
2020-2024
Boston University
2022
United States Nuclear Regulatory Commission
2021
National Patient Safety Foundation
2020
Universidade Federal do Rio Grande do Sul
2014-2019
<h3>Importance</h3> Preclinical studies have shown that transcranial near-infrared low-level light therapy (LLLT) administered after traumatic brain injury (TBI) confers a neuroprotective response. <h3>Objectives</h3> To assess the feasibility and safety of LLLT acutely moderate TBI neuroreactivity to through quantitative magnetic resonance imaging metrics neurocognitive assessment. <h3>Design, Setting, Participants</h3> A randomized, single-center, prospective, double-blind,...
Abstract The inability to accurately, efficiently label large, open-access medical imaging datasets limits the widespread implementation of artificial intelligence models in healthcare. There have been few attempts, however, automate annotation such public databases; one approach, for example, focused on labor-intensive, manual labeling subsets these be used train new models. In this study, we describe a method standardized, automated based similarity previously validated, explainable AI...
Background Rapid volumetric imaging protocols could better utilize limited scanner resources. Purpose To develop and validate an optimized 6‐minute high‐resolution brain MRI examination using Wave‐CAIPI encoding. Study Type Prospective. Population/Subjects Ten healthy subjects 20 patients with a variety of intracranial pathologies. Field Strength/Sequence At 3 T, MPRAGE, T 2 ‐weighted SPACE, SPACE FLAIR, SWI were acquired at 9‐fold acceleration for comparison 2–4‐fold conventional GRAPPA....
<h3>BACKGROUND AND PURPOSE:</h3> The use of MR imaging in emergency settings has been limited by availability, long scan times, and sensitivity to motion. This study assessed the diagnostic performance an ultrafast brain protocol for evaluation acute intracranial pathology department inpatient settings. <h3>MATERIALS METHODS:</h3> Sixty-six adult patients who underwent were included study. All both reference protocols. Both protocols consisted T1-weighted, T2/T2*-weighted, FLAIR, DWI...
<h3>BACKGROUND AND PURPOSE:</h3> SWI is valuable for characterization of intracranial hemorrhage and mineralization but has long acquisition times. We compared a highly accelerated wave–controlled aliasing in parallel imaging (CAIPI) sequence with 2 commonly used alternatives, standard T2*-weighted gradient recalled-echo (T2*W GRE), routine clinical brain at 3T. <h3>MATERIALS METHODS:</h3> A total 246 consecutive adult patients were prospectively evaluated using conventional or T2*W GRE an...
<h3>BACKGROUND AND PURPOSE:</h3> Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard for evaluation of regional tissue volumes. <h3>MATERIALS METHODS:</h3> performed scan-rescan experiments in 10 healthy volunteers the intraindividual variability volumes measured using and Wave-MPRAGE sequences. then evaluated 43 consecutive patients undergoing imaging. Patients underwent...
Abstract Background Despite the high prevalence of depressive symptoms in Fabry disease (FD), it is unclear which patient characteristics are important relation to these symptoms. Additionally, impact coping styles FD has been unexplored. Determining different factors relating can guide both prevention and treatment Methods Depressive (Center for Epidemiologic Studies Depression scale (CESD)) (Utrecht Coping List) were assessed a Dutch cohort. Other potentially variables identified from...
Abstract Risk prediction requires comprehensive integration of clinical information and concurrent radiological findings. We present an upgraded chest radiograph (CXR) explainable artificial intelligence (xAI) model, which was trained on 241,723 well-annotated CXRs obtained prior to the onset COVID-19 pandemic. Mean area under receiver operating characteristic curve (AUROC) for detection 20 radiographic features 0.955 (95% CI 0.938–0.955) PA view 0.909 0.890–0.925) AP view. Coexistent...
Background Low-level light therapy (LLLT) has been shown to modulate recovery in patients with traumatic brain injury (TBI). However, the impact of LLLT on functional connectivity when at rest not well studied. Purpose To use MRI assess effect whole-brain resting-state (RSFC) moderate TBI acute (within 1 week), subacute (2-3 weeks), and late-subacute (3 months) phases. Materials Methods This is a secondary analysis prospective single-site double-blinded sham-controlled study conducted...
Current research on medical image processing relies heavily the amount and quality of input data. Specifically, supervised machine learning methods require well-annotated datasets. A lack annotation tools limits potential to achieve high-volume scaled systems with a proper reward mechanism. We developed MarkIt, web-based tool, for collaborative imaging data artificial intelligence blockchain technologies. Our platform handles both Digital Imaging Communications in Medicine (DICOM) non-DICOM...
Purpose We introduce and validate an artificial intelligence (AI)‐accelerated multi‐shot echo‐planar imaging (msEPI)‐based method that provides T1w, T2w, , T2‐FLAIR, DWI images with high SNR, tissue contrast, low specific absorption rates (SAR), minimal distortion in 2 minutes. Methods The rapid technique combines a novel machine learning (ML) scheme to limit g‐factor noise amplification improve magnetization transfer preparation module provide clinically desirable per‐shot EPI undersampling...
Previous studies have used parallel imaging (PI) techniques to decrease spine magnetic resonance (MRI) protocol acquisition times. Recently developed MRI sequences allow even faster acquisitions. Our purpose was develop a lumbar using PI with GRAPPA (generalized autocalibrating partially acquisition) and simultaneous multislice (SMS)-based sequence evaluate its diagnostic performance compared standard protocol.Ten patients were scanned in 3-Tesla scanner (MAGNETOM Skyra, Siemens Healthcare)....
Background and purpose: Brain magnetic resonance imaging (MRI) examinations using high-resolution 3D post-contrast sequences offer increased sensitivity for the detection of metastases in central nervous system but are usually long exams. We evaluated whether diagnostic performance a highly accelerated Wave-CAIPI T1 SPACE sequence was non-inferior to standard evaluation brain metastases. Materials methods: 33 patients undergoing were prospectively with an optimized sequence, which three...
<h3>BACKGROUND AND PURPOSE:</h3> The development of new MR imaging scanners with stronger gradients and improvement in coil technology, allied emerging fast techniques, has allowed a substantial reduction scan times. Our goal was to develop 10-minute gadolinium-enhanced brain protocol accelerated sequences evaluate its diagnostic performance compared the standard clinical protocol. <h3>MATERIALS METHODS:</h3> Fifty-three patients referred for contrast were scanned 3T scanner. Each image...
To determine the neurodevelopment outcomes after therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE) and identify magnetic resonance imaging (MRI) findings associated with neurological outcome in a middle-income country.All infants born 35 completed weeks' gestation signs of moderate to severe evidence perinatal asphyxia before 6 hours life were submitted whole-body imaged at 18 ± 8.4 days (range 7-33 days) birth. Surviving had assessed 12 months age by trained...
Abstract This study investigates the relationship between objective cognitive impairment (OCI), subjective complaints and depressive symptoms in men women with classical non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, structured interview depression scale (CESD). Eighty-one patients were included (mean age 44.5 ± 14.3, 35% men, 74% classical). Subjective reported by 64% of all patients. OCI present thirteen (16%), predominantly...
Our aim was to evaluate an ultrafast 3D-FLAIR sequence using Wave-controlled aliasing in parallel imaging encoding (Wave-FLAIR) compared with standard the visualization and volumetric estimation of cerebral white matter lesions a clinical setting. Forty-two consecutive patients underwent 3T brain MR imaging, including (acceleration factor = 2, scan time 7 minutes 50 seconds) resolution-matched Wave-FLAIR sequences 6, 2 45 seconds for 20-channel coil; acceleration 9, 1 minute 32-channel coil)...
Abstract Background and Purpose High‐resolution three‐dimensional (3D) post‐contrast imaging of the brain is essential for comprehensive evaluation inflammatory, neoplastic, neurovascular diseases brain. 3D T1‐weighted spin‐echo‐based sequences offer increased sensitivity detection enhancing lesions but are relatively prolonged examinations. We evaluated whether a highly accelerated Wave‐controlled aliasing in parallel (Wave‐CAIPI) T1‐sampling perfection with application‐optimized contrasts...
It is unclear which patients with Fabry disease (FD) are at risk for progression of white matter lesions (WMLs) and brain infarctions whether enzyme replacement therapy (ERT) changes this risk. The aim study was to determine the effect ERT clinical characteristics on WMLs MRI in FD.MRIs were assessed (Fazekas scale), basilar artery diameter (BAD). (renal cardiac involvement, cardiovascular factors, complications, BAD) WML infarction evaluated using mixed models.One hundred forty-nine...
Patients with Fabry disease (FD) have a high prevalence of depressive symptoms and can suffer from cognitive impairment, negatively affecting their life. The course functioning in FD is unknown. aim this prospective cohort study was to describe changes identify related variables patients over 1 year. Assessments were conducted twice, using neuropsychological test battery the Centre Epidemiological Studies Depression scale (CESD). Eighty-one included which 76 (94%) completed both assessments...
Objective This study aimed to describe the experience with a protocol of therapeutic hypothermia (TH) in southern Brazil. Study Design Newborns gestational age > 35 weeks evidence perinatal asphyxia plus moderate or severe encephalopathy were recruited between March 2011 and November 2017. Whole-body for 72 hours, starting within first 6 hours life was used. Survivors underwent magnetic resonance imaging (MRI) electroencephalogram (EEG). The primary outcome death during hospitalization...