A5031779253- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health and Wellbeing Research
- Workplace Health and Well-being
- Transcranial Magnetic Stimulation Studies
- Employment and Welfare Studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Work-Family Balance Challenges
- Suicide and Self-Harm Studies
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
CHA Bundang Medical Center
2019-2022
CHA University
2019-2022
Gachon University
2021
Gachon University Gil Medical Center
2021
Korea University
2012-2019
Korea University Medical Center
2013-2019
Ansan University
2016
Background DNA methylation in the promoter region of glucocorticoid receptor gene (NR3C1) is closely associated with childhood adversity and suicide. However, few studies have examined NR3C1 relation to major depressive disorder (MDD) hippocampal subfield volumes. We investigated possible association between structural brain alterations MDD comparison healthy controls. Methods compared degree peripheral blood non-psychotic outpatients that Correlations among methylation, abnormalities...
Abstract A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated interactive effects allelic variants, DNA methylation, and diagnosis MDD on structural changes entire brain. One hundred fourteen patients eighty-eight healthy controls underwent T1-weighted magnetic resonance imaging genotyping, including methylation intron 7. analyzed volume cortical subcortical regions thickness using...
Abstract Recent studies have reported that methylation of the brain-derived neurotrophic factor ( BDNF ) gene promoter is associated with major depressive disorder (MDD). This study aimed to investigate association between cortical thickness and promoters as well serum levels in MDD. The participants consisted 65 patients recurrent MDD age- gender-matched healthy controls. Methylation were compared groups. right medial orbitofrontal, lingual, lateral occipital, left pars triangularis,...
Abstract Background: The hippocampus is not a uniform structure, but rather consists of multiple, functionally specialized subfields. Few studies have explored hippocampal subfield volume difference in the same sample major depressive disorder (MDD) and bipolar (BD) cases. We aimed to investigate between patents with MDD BD healthy controls (HCs). Methods: A total 102 55 patients 135 HCs were recruited underwent T1-weighted image. Hippocampal was calculated by automated segmentation...
The SLC6A15 gene has been identified as a novel candidate for major depressive disorder (MDD). It is presumed to be involved in the pathophysiology of MDD through regulation glutamate transmission brain. However, involvement this microstructural changes white matter (WM) tracts remains unclear. We aimed investigate influence polymorphism (rs1545853) on structural integrity WM cortico-limbic network.Eighty-six patients with and 64 healthy controls underwent T1-weighted magnetic resonance...
Abstract The tryptophan hydroxylase‐2 ( TPH2 ) gene is considered a promising genetic candidate regarding its association with predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and regarded as potential endophenotype in psychiatric disorders. They aimed investigate alterations prefrontal cortex anterior cingulate their rs4570625 polymorphism patients MDD. One hundred thirteen MDD eighty‐six healthy controls...
Insomnia is a common disorder that affects vast number of patients; the hyperarousal theory insomnia postulates patients with are physiologically activated not only at nighttime but also during daytime. We aimed to investigate differences in resting-state functional connectivity (RSFC) thalamus cortical areas between and healthy controls.All participants completed clinical questionnaires underwent portable polysomnography fMRI.Patients group (n = 50) showed increased RSFC right medial...