A5014444855- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Wireless Body Area Networks
- Cutaneous lymphoproliferative disorders research
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Infectious Diseases and Mycology
- Cardiovascular Syncope and Autonomic Disorders
- Electromagnetic Fields and Biological Effects
- Wireless Power Transfer Systems
- Ultrasound and Hyperthermia Applications
- Cystic Fibrosis Research Advances
- Phytochemical compounds biological activities
- Quality and Safety in Healthcare
- RFID technology advancements
- Ultrasonics and Acoustic Wave Propagation
- Muscle activation and electromyography studies
- Advanced Chemical Sensor Technologies
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
Istituto Superiore di Sanità
2013-2024
Policlinico Umberto I
2023
National Institute of Health
2006-2020
Sapienza University of Rome
2000-2018
University of Birmingham
2018
Edwards (United Kingdom)
2018
Centre de Recherche en Neurosciences de Lyon
2018
Brighton and Sussex Medical School
2018
University of Sussex
2018
Health City Institute
2017
MRI induced heating on PM leads is a very complex issue. The widely varying results described in literature suggest that there are many factors influence the degree of and not always adequately addressed by existing testing methods. We present wide database experimental measurements metallic wires 1.5 T RF coil. aim these to systematically quantify contribution some potential involved heating: length geometric structure lead; implant location within body lead path; shape phantom used...
Abstract In this study, we used single nucleotide polymorphism and comparative genomic hybridization array to study DNA copy number changes loss of heterozygosity for 28 patients affected by Sézary syndrome (SS), a rare form cutaneous T-cell lymphoma (CTCL). Our data identified, further confirming previous studies, recurrent losses 17p13.2-p11.2 10p12.1-q26.3 occurring in 71% 68% cases, respectively; common gains were detected 17p11.2-q25.3 (64%) chromosome 8/8q (50%). Moreover, identified...
Purpose To assess the risk of radiofrequency (RF) ‐induced heating in patients with MR‐conditional pacemaker (PM) systems, presence another lead abandoned from a previous implant. Methods Four commercial leads were placed beside PM system, inside human trunk simulator. The phantom has been exposed to RF generated by 64 MHz body bird‐cage coil (whole‐body specific absorption rate [SAR] = 1 W/kg) and induced was measured at tip Configurations that maximize coupling between field have tested,...
Abstract Purpose To evaluate the effect of geometry implantable pacemakers (PMs) on lead heating induced by magnetic resonance imaging (MRI). Materials and Methods In vitro experiments were conducted with two different setups, using fluoroptic probes to measure temperature increase. The first experiment consisted a rectangular box filled gelled saline pacemaker its leads. This was exposed in an MRI birdcage coil sinusoidal 64‐MHz field calibrated whole‐body specific absorption rate (WB‐SAR)...
The purpose of this work is to evaluate the error associated with temperature and SAR measurements using fluoroptic probes on pacemaker (PM) leads during magnetic resonance imaging (MRI). We performed leads, excited a 25, 64, 128 MHz current. PM lead tip heating was measured thermometer (Luxtron, Model 3100, USA). Different contact configurations between pigmented portion probe were investigated find position minimizing underestimation. A computer model used estimate made by in measurement....
Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, study attempted categorize functionally relevant genes within genome-wide expression profile human ALS skeletal muscle, using microarray technology gene regulatory network analysis. The correlation structures significantly change between patients controls,...
Abstract The analysis of P-wave template has been widely used to extract indices Atrial Fibrillation (AF) risk stratification. aim this paper was assess the potential variability over time in patients suffering from atrial fibrillation. features extracted together with novel have estimated a population persistent AF and compared those control subjects. We quantify using three algorithms we indices: one based on cross-correlation coefficients among P-waves (Cross-Correlation Index, CCI),...
MRI may cause tissue heating in patients implanted with pacemakers (PMs) or cardioverters/defibrillators. As a consequence, these are often preventatively excluded from investigations. The issue has been studied for several years now, order to identify the mechanisms involved heat generation, and define safety conditions by which be extended active implants. In this sense, numerical studies not only widen range of experimental measurements, but also model realistic patient's anatomy on it is...
The changes in between gene expression correlation structure induced heart tissue by atrial fibrillation are studied means of a graph theoretical approach. As expected general statistical mechanics principles, the disease increases connectivity regulation network; multiscale character analysis allows us to get both appreciation network and sketching biological interpretation disease. presence still largely unknown, scale invariant, global field encompassing entire genome is demonstrated as well.
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Assessment of the risk due to exposure emf with particular reference protection sensitive subjects. Purpose. The work illustrates useful elements for assessment workers exposed electromagnetic fields, also in subjects such as those active implantable medical devices (AIMD).Methods. approach introduced by Legislative Decree 81/08 does not explicitly include operational criteria and specific measures In case DMIA, employer may refer relevant harmonized technical standards.Results. They are...
The radio frequency identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related traceability of people and things. Unfortunately, there are still some barriers limiting large-scale deployment these innovative technologies field. Among these, evaluation potential thermal nonthermal effects due exposure biopharmaceutical products electromagnetic fields is very challenging, but slightly investigated. This paper aims setup a...
Abstract MRI‐induced heating on endocardial leads is a serious concern for the safety of patients with implantable pacemakers or cardioverter‐defibrillator. The lead depends many factors and its amount largely variable. In this study, we investigated role those structural properties that are reported accompanying documents device: ( 1 ) fixation modality (active vs. passive); 2 number electrodes (unipolar bipolar); 3 length; 4 tip surface; 5 ring resistance. vitro temperature specific...
The aim of this study was to evaluate whether global system for mobile communication (GSM) cellular phones can affect the home monitoring (HM) function implemented in last generation pacemakers (PM). Methods: We performed vitro and vivo tests on BA03 PM (Biotronik GmbH, Berlin, Germany). In we evaluated an improper HM procedure or altered patient‐activated occurred. used two phone models, with a fixed external internal antenna, positioned close both phone‐like device, during handover,...
This article presents two signal processing techniques for the analysis of intracardial electrograins in patients with atrial fibrillation (AF). The first, number occurrences (NO), is aimed at quantifying level organization signal. second, index synchronization (IS), quantifies degree synchrony electrograms from adjacent sites. proposed indexes are applied to multielectrode basket catheter recordings chronic or electrically induced AF
The aim of this study was to investigate the mechanisms by which radiated radiofrequency (RF) GSM (global system for mobile communication) signal may affect pacemaker (PM) function. We measured at output sensing amplifier PMs with various configurations low-pass filters. used three versions same PM model: one a block capacitor short circuits high-frequency signals; ceramic feedthrough capacitor, hermetically sealed mechanism connecting internal electronics external connection block, and...
The aim of this study is to evaluate the heart rate adaptation obtained by a pacemaker, based on measure ventricular impedance in patients undergoing autonomic challenges. evaluation procedure was analysis mean value (MV) and variability (HRV) RR systolic pressure intervals, according set neurovegetative stressors (controlled respiration supine position during active standing; mental stress; handgrip, noninvasive sinusoidal stimulation carotid baroreceptors). Each test lasted 5 minutes....
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with extensive structural, contractile, and electrophysiological remodeling. In this manuscript we re-analyzed gene expression data from a microarray experiment on AF patients control tissues, using new paradigm based posteriori unsupervised strategy in which discrimination of comes out purely syntactical premises. This paradigm, more adherent to biological reality where genes work highly connected networks, allowed...
The electrocardiogram (ECG) signal can be derived from different sources. These include systems for surface ECG, Holter monitoring, ergometric stress tests, and telemetry bedside monitoring of vital parameters, which are useful rhythm ST-segment analysis ECG screening electrical sudden cardiac death predictors. A precise diagnosis is based upon correct recording, elaboration, presentation the signal. Several sources artefacts potential external causes may influence quality original...