Marco Manfrin

ORCID: 0000-0001-7002-1972
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About
Contact & Profiles
Research Areas
  • Vestibular and auditory disorders
  • Hearing, Cochlea, Tinnitus, Genetics
  • Ear Surgery and Otitis Media
  • Ophthalmology and Eye Disorders
  • Glaucoma and retinal disorders
  • Hearing Loss and Rehabilitation
  • Cerebral Venous Sinus Thrombosis
  • Spinal Fractures and Fixation Techniques
  • Advanced MRI Techniques and Applications
  • Noise Effects and Management
  • Ear and Head Tumors
  • Facial Nerve Paralysis Treatment and Research
  • Meningioma and schwannoma management
  • Visual perception and processing mechanisms
  • Neural Networks and Applications
  • Congenital Ear and Nasal Anomalies
  • Fuzzy Logic and Control Systems
  • Speech and dialogue systems
  • Phytoplasmas and Hemiptera pathogens
  • Animal Vocal Communication and Behavior
  • Inflammasome and immune disorders
  • Diverse academic and cultural studies
  • Vascular anomalies and interventions
  • Robotics and Automated Systems
  • linguistics and terminology studies

Istituti di Ricovero e Cura a Carattere Scientifico
2011-2024

University of Pavia
2011-2024

Policlinico San Matteo Fondazione
1990-2020

We examined clinical aspects of Benign Paroxysmal Vertigo (BPV) in infancy and its most frequent differential diagnosis, particular analogies differences with forms “migrainous vertigo” (MV) later onset. During a long-term follow-up 7 cases BPV, diagnosed according to the Basser criteria, 5 BPV spontaneously resolved 6 patients developed migraine other migraine-related symptoms. This course differs from that described for MV only age onset headache chronological relationship vertigo. The...

10.1046/j.1468-2982.1994.1406458.x article EN Cephalalgia 1994-12-01

La malattia MYH9-correlata è una rara sindrome genetica caratterizzata da piastrinopenia congenita associata al rischio di sviluppare, durante l’infanzia o l’età adulta, ipoacusia neurosensoriale, nefropatia e cataratta presenile ad andamento evolutivo. Furono inclusi in uno studio retrospettivo tutti i casi con sordità severa a profonda arruolati consecutivamente nel Registro Italiano dei pazienti affetti MYH9-correlata. popolazione esaminata coinvolse 147 Italiani MYH9-correlata:...

10.14639/0392-100x-702 article IT Acta Otorhinolaryngologica Italica 2016-10-01

La vertigine e l’instabilità sono sintomi molto comuni nella popolazione la cui prevalenza è stimata tra il 20 56%. L’obiettivo del nostro lavoro stato quello di determinare questi in una 2672 soggetti. È somministrato loro un questionario; prima parte stati richiesti i dati demografici se avessero mai sofferto o instabilità vita. L’età media campione stata 48,3 ± 15 anni, 46,7% erano maschi. Sul totale della 1077 (40,3%) hanno riferito aver vita, con primo episodio occorso all’età 39,2 15,4...

10.14639/0392-100x-847 article IT Acta Otorhinolaryngologica Italica 2016-05-01

La vertigine parossistica posizionale benigna (VPPB) è il tipo più comune di periferica. Frequentemente dopo primo episodio la VPPB presenta recidive, con un tasso ricorrenza tra 15% ed 50%. Ad oggi non vi chiarezza sui processi eziopatogenetici che portano al distacco degli otoconi né su quali siano i fattori rendono una patologia recidivante, ma recenti studi epidemiologici hanno evidenziato possibile associazione rischio cardiovascolari. Lo scopo del presente studio (Sesto Senso Survey)...

10.14639/0392-100x-1121 article IT Acta Otorhinolaryngologica Italica 2017-08-01

Neurophysiological measurements of the vestibular function for diagnosis and follow-up evaluations provide an objective assessment, which, unfortunately, does not necessarily correlate with patients' self-feeling. The literature provides many questionnaires to assess outcome rehabilitation programs disequilibrium, but only Dizziness Handicap Inventory (DHI) is Italian translation available, validated on a small group patients suffering from peripheral acute vertigo. We translated reliability...

10.3389/fneur.2017.00528 article EN cc-by Frontiers in Neurology 2017-10-10

Background: The diagnosis of benign paroxysmal positional vertigo (BPPV) involving the lateral semicircular canal (LSC) is traditionally entrusted to supine head roll test, also known as yaw test (SHYT), which usually allows identification pathologic side and BPPV form (geotropic vs. apogeotropic). Nevertheless, SHYT may not always allow easy detection affected canal, resulting in similar responses on both sides intense autonomic symptoms patients with recent onset vertigo. newly introduced...

10.3389/fneur.2020.578305 article EN cc-by Frontiers in Neurology 2020-11-19

Positional downbeat nystagmus (pDBN) represents a relatively frequent finding. Its possible peripheral origin has been widely ascertained. Nevertheless, distinguishing features of positional nystagmus, including latency, paroxysm and torsional components, may be missing, resulting in challenging differential diagnosis with central pDBN. Moreover, case benign paroxysmal vertigo (BPPV), detection the affected canal as involvement non-ampullary arm posterior semicircular (PSC) results same...

10.3389/fneur.2020.578588 article EN cc-by Frontiers in Neurology 2020-10-15

The aim of the present study was to assess feasibility and utility 3D printing technology in surgical planning a transcutaneous bone-conduction hearing device (Bonebridge®) (BB), focusing on identification proper location placement transducer. printed (3DP) models three human cadaveric temporal bones, previously submitted CT scan, were created with representation topographic bone thickness map sinus pathway outer surface. 3DP model used detect most suitable for BB. A transparent mask that...

10.14639/0392-100x-1625 article IT cc-by-nc-nd Acta Otorhinolaryngologica Italica 2018-06-01

In response to passive high-acceleration head impulses, patients with low vestibulo-ocular reflex (VOR) gains often produce covert (executed while the is still moving) corrective saccades in direction of deficient slow phases. Here we examined 23 using passive, and 9 also active, impulses acute (< 10 days from onset) unilateral vestibular neuritis VOR gains. We found that when are larger than 10°, slow-phase component inhibited, even though inhibition increases further time reacquire...

10.1152/jn.00864.2016 article EN Journal of Neurophysiology 2017-04-13

The head impulse test (HIT) is nowadays recognized as the gold standard for clinical testing of angular vestibulo-ocular reflex (VOR). By imposing unpredictable, abrupt rotations in canal pairs' planes it aims at unveiling dysfunction semicircular towards which rotated based on Ewald's II law. Functional VOR assessing ability to stabilize gaze space and thus allow clear vision during movements. HIT device (HITD) approach exploits impulsive spawning a range accelerations while requiring...

10.3233/ves-140531 article EN Journal of Vestibular Research 2014-12-17

Acute vertigo is defined as the perception of movement oneself or surroundings in absence actual motion and it a frequent cause for emergency department admissions. The utilization medical resources duration hospital stay this kind symptom high. Furthermore, efficiency brain imaging acute phase low, considering limited sensitivity both CT MRI diagnosing diseases that are causes central type vertigo. Relying on tests can provide false reassurance event negative results prolong in-hospital...

10.1007/s11739-024-03664-x article EN cc-by Internal and Emergency Medicine 2024-07-13

Endolymphatic hydrops has been documented as a possible complication of cochlear implantation; however, few studies have addressed its treatment. We describe the first case ever reported delayed endolymphatic after implant successfully treated with intratympanic gentamicin injection. A detailed discussion this focus on management and outcomes will be provided in comparison literature data. The injection demonstrated to an effective treatment for symptomatic implantation. advocate further...

10.5152/iao.2024.23122 article EN cc-by-nc The Journal of International Advanced Otology 2024-08-26

To primarily evaluate MRI-induced effects for Ultra 3D cochlear implantation in human cadavers terms of artifact generation and MR image quality.Three cadaveric heads were submitted to imaging after unilateral bilateral implantation. The 1.5 T examination protocol was chosen accordance with our institutional the assessment brain pathology. maximal signal void size measured according each sequence plane. Two experienced neuro-radiologists one otoneurosurgeon independently evaluated quality...

10.1007/s00405-020-06464-z article EN cc-by European Archives of Oto-Rhino-Laryngology 2020-11-18

Expert systems (ES) are a new tool for information processing developed by the branch of computer science known as artifical intelligence. ES capable solving problems in given domain using knowledge and emulating behaviour specialists that field. can be used powerful tools education since they able to justify their own conclusions make underlying reasoning explicit. This paper presents 'Vertigo', an aimed at classification diagnosis different forms dizziness. It has been conceived mainly...

10.1159/000276113 article EN ORL 1990-01-01

To investigate the effects for Ultra 3D cochlear implant (CI) positioning on MR imaging quality, looking at a comprehensive description of intracranial structures in cases unilateral and bilateral CI placement.Four angular positions (90°, 120°, 135° 160°) 9 cm distance from outer-ear canal were explored. The 1.5 T MRI assessment included our institutional protocol investigation brain pathologies without gadolinium application. Three investigators (two experienced neuroradiologists one...

10.1007/s00405-021-07005-y article EN cc-by European Archives of Oto-Rhino-Laryngology 2021-08-09

Objective To report the personalized decision-making pro- cess adopted for a cochlear implant (CI) candidate requiring magnetic resonance imaging (MRI) brain surveillance. Study Design Clinical capsule report. Setting Tertiary academic referral center. Patient A 23-year-old man affected by posttraumatic bilat- eral profound hearing loss, already in radiological follow-up suspected small left cuneal low-grade glioma. Interventions multidisciplinary approach involving preoperative MRI...

10.1097/mao.0000000000003532 article EN Otology & Neurotology 2022-06-16

Introduction. The retrosigmoidal (RS) placement of the Bonebridge system (BB) has been advocated for cases unfavourable anatomical or clinical conditions which contraindicate transmastoid-presigmoidal positioning. However, these disadvantageous conditions, combined with considerable dimensions implant, may represent a challenge, especially surgeons no skull base experience. Moreover, literature reports only limited experience concerning RS implantation BB system. Methods. A multicentre,...

10.14639/0392-100x-n0609 article EN cc-by-nc-nd Acta Otorhinolaryngologica Italica 2021-02-01

AbstractThe effects of endolymphatic and perilymphatic pressure changes on resting mechanically evoked responses were studied in isolated posterior semicircular canals the frog. results demonstrated that ampullar receptors are extremely sensitive to hydrostatic (0.25 mm H20 sufficient produce distinct changes), being inhibited by increases facilitated ones. Intracellular recordings from single afferent axons showed result a modified transmitter release synaptic po'e hair cells. Unlike...

10.3109/00016489109138417 article EN Acta Oto-Laryngologica 1991-01-01

In recent years the increasing development of hearing devices has led to a critical analysis standard methods employed evaluate function. Being too far from reality, conventional investigation loss based on pure-tone threshold audiometry and mono/disyllabic word lists, presented in quiet conditions, been shown be inadequate. A speech-in-noise test using roving-level adaptive method employs target competing signals varying level order reproduce everyday life speaking conditions explore more...

10.14639/0392-100x-1133 article IT Acta Otorhinolaryngologica Italica 2016-12-01
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