A5004348658- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- Ethnobotanical and Medicinal Plants Studies
- Toxoplasma gondii Research Studies
- Bioactive natural compounds
- Toxin Mechanisms and Immunotoxins
- Sesquiterpenes and Asteraceae Studies
- Traditional Chinese Medicine Analysis
- melanin and skin pigmentation
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Toxicity and Pharmacological Properties
- Allelopathy and phytotoxic interactions
- Chemical synthesis and alkaloids
- Chromatography in Natural Products
- Phytochemistry Medicinal Plant Applications
- Plant Diversity and Evolution
- African Botany and Ecology Studies
Institut de Chimie Moléculaire de Reims
2016-2025
Centre National de la Recherche Scientifique
2015-2024
Université de Reims Champagne-Ardenne
2012-2024
Centre Hospitalier Universitaire de Reims
2020
Hôpital Robert-Debré
2008-2015
Institut de Recherche pour le Développement
2006-2008
Laboratoire des Biomolécules
2008
Pierre Fabre (France)
2002-2006
Unité Matériaux et Transformations
2005
The search for new antimicrobials should take into account drug resistance phenomenon. Medicinal plants are known as sources of potent antimicrobial compounds including flavonoids. objective this investigation was to evaluate the activities flavonoid glycosides from Graptophyllum grandulosum, well determine their mechanism antibacterial action using lysis, leakage and osmotic stress assays.The plant extracts were prepared by maceration in organic solvents. Column chromatography n-butanol...
Resistance of bacteria and fungi to antibiotics is one the biggest problems that faces public health. The present work was designated evaluate antimicrobial activities saponins from Melanthera elliptica their synergistic effects with standard against pathogenic phenotypes. plant extract prepared by maceration in methanol. methanol partitioned into ethyl acetate n-butanol extracts. Column chromatography followed purification different fractions led isolation four saponins. Their structures...
Naturally occurring flavonoids have been reported to possess various pharmacological properties. The aim of this study was evaluate the antimicrobial and antioxidant activities MeOH extract from leaves Oncoba spinosa, a plant used for treatment syphilis, wounds sexual impotence.The prepared by maceration in methanol sequentially fractionated column chromatography. structures isolated compounds were elucidated on basis spectral studies comparison with published data. its evaluated their...
Three new bidesmosidic saponins (1−3) and a ursane triterpenoid, 2α,3β,11α,23-tetrahydroxyurs-12-en-28-oic acid (4), along with seven known compounds, were isolated from methanolic extract of the leaves Symplocos lancifolia. The found to possess same sugar unit part, composed two β-d-glucose moieties one α-l-rhamnose moiety, linked maslinic acid, arjunolic asiatic respectively. Their structures elucidated by interpretation their 1D 2D NMR spectra completed analysis HRESIMS data....
Antibiotic resistance has contributed to the burden of infectious diseases both in hospital and community setting, represents a great threat public health. Previous studies have revealed role reactive oxygen species as intermediate mediators tissue damage, following antibiotherapies, indicating need associating antioxidants these treatments. Therefore, present work was designed study antibacterial, antifungal antioxidant activities extracts compounds from Rumex abyssinicus Jacq....
The haemolytic activity of 59 samples, natural or partially synthetic pure saponins and mixtures thereof, was determined. tested possessed triterpenic genins six structural skeleton types were studied. Structure-activity relationships established by comparison the functional groups each saponin branched sugar chains attached to aglycone. is shown depend on number units in chains, as well presence an osidic chain position 3 genin such carboxylic 16a-OH. Comparison activities monodesmosidic...
Context: The phytochemical study and biological activities of Astragalus armatus Willd. subsp. numidicus (Fabaceae) pods, an endemic shrub Maghreb, are reported.Objective: This isolates the secondary metabolites determines bioactivities pods.Materials methods: chloroform, ethyl acetate n-butanol extracts hydro-ethanolic were studied. Antioxidant activity was investigated using DPPH ABTS radical scavenging, CUPRAC ferrous chelating assays at concentrations ranging from 3 to 200 μg/mL....
The apicomplexan parasite Toxoplasma gondii causes toxoplasmosis, a ubiquitous and cosmopolitan parasitosis, generally asymptomatic potentially dangerous for the fetus highly immunocompromised patients. Pyrimethamine sulfadiazine, supplemented with folic acid, are drugs of choice to treating disease, but they produce severe side effects treatments fail due drug resistance. New anti-Toxoplasma compounds needed, natural can be good source obtaining them. antiparasitic activity 40 polar...
Hallea ledermannii belongs to the Rubiaceae family. It is traditionally used managed pathologies such as dysentery, fever, malaria, gonorrhea and other diseases. The present study aimed report chemical composition antioxidant properties of root bark extracts. Antioxidant activity hydromethanolic extract was evaluated by DPPH ABTS methods. Phytochemical screening showed tannins, polyphenols, flavonoids, saponosides, leuco-anthocyanins, reducing compounds, polyterpenes sterols. total...
Abstract Introduction Alphitonia neocaledonica (Rhamnaceae) is an endemic tree of New Caledonia. Although three flavonoids have been identified in the leaves, secondary metabolite profile fruits has never investigated. Objective Phytochemical investigation A. and evaluation their anti‐oxidant, anti‐tyrosinase cytotoxic activities. Methods A hydromethanolic extract was fractionated by liquid–liquid extraction to obtain ethyl acetate n ‐butanolic fractions. The ethyl‐acetate‐soluble part...
Abstract The synthesis of α‐hederin (3‐ O ‐[α‐ L ‐rhamnopyranosyl‐(1⇄2)‐α‐ ‐arabinopyranosyl]hederagenin, 1 ), δ‐hederin ‐(α‐ ‐arabinopyranosyl)hederagenin, 3 and three related triterpenoid saponins is described as part a study the structure−activity relationships between hemolytic activity. 4‐Methoxybenzyl α‐ ‐arabinopyranoside ( 11 ) was synthesized first then used to prepare different arabinose acceptors. Glycosylation acceptors 2,3,4‐tri‐ ‐benzoyl‐α‐ ‐rhamnopyranosyl trichloroacetimidate...
Maytenus buchananii is worldwide distributed small evergreen tree traditionally used as anti-tumor, anti-ulcer, anti-inflammatory, and antimicrobial. The column chromatography of the MeOH extract M. leaves followed by purification different fractions led to isolation nine known flavonoids. Their structures were elucidated on basis spectrum analysis, comparison with those from literature. antibacterial activity was assessed performing minimum inhibitory concentration (MIC), bactericidal (MBC)...