A5102436948- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic Associations and Epidemiology
- Infrastructure Resilience and Vulnerability Analysis
- Immune cells in cancer
- Genomics and Rare Diseases
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Cellular Mechanics and Interactions
- Medical Device Sterilization and Disinfection
- Smart Grid Security and Resilience
- Blood properties and coagulation
- Clusterin in disease pathology
- interferon and immune responses
- Healthcare and Environmental Waste Management
- Peripheral Artery Disease Management
- Phagocytosis and Immune Regulation
- Cardiac Structural Anomalies and Repair
- Skin and Cellular Biology Research
- Inflammasome and immune disorders
Peking University
2024-2025
Hospital for Sick Children
2023-2025
Peking University First Hospital
2025
Zhengzhou University
2024
Weifang Medical University
2024
Henan Provincial People's Hospital
2024
Long Island University
2023
University of Toronto
2023
SickKids Foundation
2023
Allegheny Health Network
2023
BackgroundCardiomyopathy is a clinically and genetically heterogeneous heart condition that can lead to failure sudden cardiac death in childhood. While it has strong genetic basis, the aetiology for over 50% of cardiomyopathy cases remains unknown.MethodsIn this study, we analyse characteristics tandem repeats from genome sequence data unrelated individuals diagnosed with Canada United Kingdom (n = 1216) compare them those found general population. We perform burden analysis identify...
STING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in CGAS-STING1 signaling pathway, crucial for induction type I IFN (interferon) production and eliciting innate immunity. Nevertheless, overactivation or sustained activation has been closely associated with onset autoimmune disorders. Notably, majority these disorders manifest as an upregulated expression interferons IFN-stimulated genes (ISGs). Hence, strict regulation activity paramount to preserve...
Abstract Local recurrence and distal metastasis negatively impact the survival quality of life in patients with papillary thyroid cancer (PTC). Therefore, identifying potential biomarkers therapeutic targets for PTC is clinically crucial. In this study, we performed a multiomics analysis that identified subset CD36+ proinflammatory macrophages within tumor microenvironment PTC. The recruitment to premalignant regions strongly correlated unfavorable outcomes PTC, presence tumor-infiltrating...
Abstract Background Trinucleotide repeat expansions are an emerging class of genetic variants associated with various movement disorders. Unbiased genome‐wide analyses can reveal novel genotype–phenotype associations and provide a diagnosis for patients families. Objective The aim was to identify the cause severe progressive disorder phenotype in 2 affected brothers. Methods A family brothers unaffected parents had extensive phenotyping since birth. Whole‐genome long‐read sequencing methods...
Abstract Bloodstream infection (BSI) is a frequent but lethal complication in hematologic patients with febrile neutropenia (FN). However, blood culture (BC) only detects an organism 20%–30% of FN. We aimed to evaluate the diagnostic performance metagenomic next-generation sequencing (mNGS) as first-line method BSI. This study was prospectively performed four Chinese centers. In aged ≥15 years diseases, peripheral specimens were collected per patient for simultaneous BC and mNGS at onset The...
Congenital heart disease (CHD) is the most common birth defect. We performed Illumina short-read genome sequencing (GS) of 1,101 probands, which identified a genetic cause in 16% cases. PacBio long-read GS 43 genotype-elusive patients. Paired analysis revealed higher detection with single nucleotide variants, deletions, duplications, and insertions as well fewer false-positives for indels inversions. Long-read had coverage nine CHD genes, but low depth (<10×) intragenic regions four these...
The matrix viscosity plays a critical role in indirecting the cellular responses and apoptosis of tumor cells exhibits somewhat different mechanotransduction mechanisms.
Vascular dementia (VD), a chronic syndrome of acquired intellectual impairment resulting from cerebrovascular diseases, is closely linked to neuronal autophagy and apoptosis. As standardized extract Ginkgo biloba L. leaves, EGb761 widely applied for treating diseases owing its neuroprotective effects, with on-going research exploring therapeutic mechanisms. Rat model VD SH-SY5Y cell OGD/R injury was this study. Results showed that reduces OGD/R-elicited apoptosis autophagosome production,...
Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease have well-established associations with common genetic variation captured in polygenic score (PRS). In young adulthood, the 22q11.2 microdeletion conveys 2-fold increased mild-moderate hypertriglyceridemia. This study aimed to assess role of TG-PRS individuals this elevated baseline hypertriglyceridemia.We studied deeply phenotyped cohort adults (n = 157, median age 34 years) available...
Background: Peritoneal transport status is important not only for prescription, but also as a prognostic index. Flt-1 and Flk-1, the major vascular endothelial growth factor receptors involved in angiogenesis hyperpermeability, may play potent role determining peritoneal characteristics. However, relationship between them has been studied to date. We hypothesized that Flk-1 expression vasculature of uremic patients could be closely related baseline status. Methods: Thirty-six new without...
The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor (M2-AAB) are associated with severe preeclampsia and increased risk adverse perinatal outcomes.We conducted a case-control comparing 60 women normal pregnancy non-pregnant controls. A peptide, corresponding amino acid sequences second extracellular loops M2 receptor, synthesized as antigen for presence autoantibodies, using an enzyme-linked immunosorbent assay. frequency titer...
Abstract Background Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease have well-established associations with common genetic variation captured in polygenic score (PRS). In young adulthood, the 22q11.2 microdeletion conveys 2-fold increased mild-moderate hypertriglyceridemia. This study aimed to assess role of TG-PRS individuals this elevated baseline Methods We studied deeply phenotyped cohort adults (n=157, median age 34 years)...
Pressure steam sterilization is the preferred method for damp-heat resistant medical devices. This study aims to reveal risk of failure by using temperature and pressure detectors detect changes in performance sterilizer. Six autoclaves a general hospital were selected as research objects, key parameters such temperature, time, pressure, equilibration time verified, sterilizer was evaluated. paper provides new way monitor process hidden dangers.
<div>Abstract<p>Local recurrence and distal metastasis negatively impact the survival quality of life in patients with papillary thyroid cancer (PTC). Therefore, identifying potential biomarkers therapeutic targets for PTC is clinically crucial. In this study, we performed a multiomics analysis that identified subset CD36<sup>+</sup> proinflammatory macrophages within tumor microenvironment PTC. The recruitment to premalignant regions strongly correlated unfavorable...
<p>Supplementary Fig. S1 Enrichment of CD36+ pro-inflammatory macrophage in cancer correlates with poor outcome patients PTC.</p>
<p>Quality inspection form of IHH4</p>
<p>Cell line authentication of IHH4</p>
<p>Quality inspection form of BCPAP</p>
<p>Cell line authentication of BCPAP</p>
<p>Supplementary Fig S2</p>
<p>Supplementary Figure S13</p>
<p>Supplementary Figure S10</p>