A5040021265- Telomeres, Telomerase, and Senescence
- Skin Protection and Aging
- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Surgical site infection prevention
- Plant-based Medicinal Research
- Spinal Fractures and Fixation Techniques
- Intensive Care Unit Cognitive Disorders
- Melanoma and MAPK Pathways
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Radiopharmaceutical Chemistry and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Neuroscience and Neuropharmacology Research
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Genetic Syndromes and Imprinting
- S100 Proteins and Annexins
- Estrogen and related hormone effects
Mayo Clinic in Florida
2025
WinnMed
2024-2025
Boston University
2021-2024
Massachusetts General Hospital
2017-2023
Harvard University
2018-2023
Mayo Clinic Hospital
2023
University of Minnesota
2021
National Research Tomsk State University
2017-2018
Tomsk Polytechnic University
2017-2018
Siberian State Medical University
2014-2017
How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood by reducing kidney reabsorption and 1,25(OH)2D production, but does not directly stimulate bone FGF23 expression. Using PET scanning LC-MS, we found that increases kidney-specific glycolysis synthesis of glycerol-3-phosphate (G-3-P), which then circulates to trigger production. Further, G-3-P dehydrogenase 1 (Gpd1), a cytosolic enzyme synthesizes oxidizes NADH...
Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, aging increases, the ability properly repair heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss homeostasis leading dysregulation normal timely healing processes. The delays widespread clinical economic impacts, thus novel strategies improve are needed targeting be a promising area.
Recent works highlight the therapeutic potential of targeting cyclic guanosine monophosphate (cGMP)-dependent pathways in context brain ischemia/reperfusion injury (IRI). Although cGMP-dependent protein kinase I (cGKI) has emerged as a key mediator protective effects nitric oxide (NO) and cGMP, mechanisms by which cGKI attenuates IRI remain poorly understood. We used novel, conditional knockout mouse model to study its role cerebral IRI. assessed neurological deficit, infarct volume,...
Mitochondrial diseases are a heterogeneous group of genetic disorders caused by pathogenic variants in genes encoding gene products that regulate mitochondrial function. These located either the or nuclear genome. The TOMM7 encodes regulatory subunit translocase outer membrane (TOM) complex plays an essential role translocation nuclear-encoded proteins into mitochondria. We report individual with homozygous variant (c.73T>C, p.Trp25Arg) presented syndromic short stature, skeletal...
Abstract Activating parathyroid hormone (PTH)/PTH‐related Peptide (PTHrP) receptor (PTH1R) mutations causes Jansen's metaphyseal chondrodysplasia (JMC), a rare disease characterized by growth plate abnormalities, short stature, and PTH‐independent hypercalcemia. Previously generated transgenic JMC mouse models, in which the human PTH1R allele with H223R mutation ( H223R‐PTH1R ) is expressed osteoblasts via type Ia1 collagen or DMP1 promoters cause excess bone mass, while expression of mutant...
Aim. To assess the results of treatment in patients with deep postoperative complications after median sternotomy. Methods. The study included 33 patients: 25 males and 8 females (mean age 58.63±6.29 60.3±12.9 years, respectively). X-ray, helical computed tomography chest, sternum anterior mediastinum ultrasound, echocardiography, pulmonary function test, bacteriology, clinical laboratory tests were used to pre- post-operative conditions patients. Fistulography scintigraphy 99mTc-technetril...
Summary: Pseudoarthrosis is a severe complication of spinal fusion surgery with occurrence rates as high 35%–40%. Current options revision to correct pseudoarthrosis frequently carry failure and risk developing junctional kyphosis. Pedicled vascularized bone grafts (VBGs) are an innovative approach boost via improving structural integrity increasing the delivery blood donor site. This versatile technique can be performed at different levels without additional skin incisions minimal added...
Wide-awake and office-based hand surgeries are increasingly common. The association of these techniques with postoperative pain control has garnered recent attention. A prior study demonstrated that trigger finger release (TFR) were associated decreased perioperative opioid prescriptions compared to those performed in the operating room. current provides an in-depth analysis between surgical setting for wide-awake TFR.
Abstract Senescent cells (SnC) accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance by selectively eliminating SnCs specific aged tissues. In this study, we focused on SnC skin mice assess the effects subsequent wound healing. We applied ABT-263 directly of 24-month-old over a 5-day period. Following topical ABT-263, decreased gene expression...
Senescent cells accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance by selectively eliminating SnCs specific aged tissues. In this study, we focused on senescent skin mice assess the effects subsequent wound healing. We applied ABT-263 directly of 24-month-old over a 5-day period. Following topical ABT-263, decreased gene expression markers p16...
The article presents analysis of the results surgical treatment in patients with postoperative sterno-mediastinitis based on originally developed approach for sternal resynthesis using TiNi mesh implants compared routine method sternoraphy metallic wire. study showed that wire did not result healing more than a half while worsening fragmentation occurred. was Department Hospital Surgery Cardiovascular Courseat Siberian State Medical University. This allowed to achieve good short-term...
Non-invasive molecular imaging techniques can enhance diagnosis of neurological diseases to achieve their successful treatment. Positron emission tomography (PET) identify activated microglia and provide detailed functional information based on biology. This modality is detection isotope labeled tracers, which emit positrons. The review summarizes the developments various radiolabeled ligands for PET neuroinflammation.