A5081770197- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Ethics in Clinical Research
- Genomics and Rare Diseases
- Statistical Methods in Clinical Trials
- BRCA gene mutations in cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Opioid Use
- Pharmaceutical Practices and Patient Outcomes
- Opioid Use Disorder Treatment
- Inflammatory mediators and NSAID effects
- Biomedical Text Mining and Ontologies
- Childhood Cancer Survivors' Quality of Life
- Coronary Interventions and Diagnostics
- Metabolism and Genetic Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Pharmacology and Obesity Treatment
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Lipoproteins and Cardiovascular Health
NorthShore University HealthSystem
2017-2023
University of Florida
2019
Aim: To explore primary care physicians' views of the utility and delivery direct access to pharmacogenomics (PGx) testing in a community health system. Methods: This descriptive study assessed perspectives 15 healthcare providers utilizing qualitative individual interviews. Results: Three main themes emerged: perceived value PGx testing; challenges implementation practice; provider as well patient needs. Conclusion: While this viewed benefits avoiding side effects, titrating doses more...
To assess patient perceptions and utilization of pharmacogenomics (PGx) testing in an integrated community health system.Fifty-seven patients completed online survey assessing their experiences with PGx offered through two methods: a designated clinic or direct access in-home testing.The majority participants perceived as helpful healthcare reported understanding results. Some had concerns about privacy discrimination; most lacked familiarity the Genetic Information Nondiscrimination Act....
Abstract Although thiopurine S‐methyltransferase ( TPMT ) genotyping to guide dosing is common in the pediatric cancer population, limited data exist on testing implementation diverse, multidisciplinary settings. We established (genotype and enzyme) with clinical decision support, provider/patient education, pharmacist consultations a tertiary medical center collected over 3 years. During this time, 834 patients underwent 873 tests (147 (17%) genotype, 726 (83%) enzyme). were most commonly...
Genomic and personalized medicine implementation efforts have largely centered on specialty care in tertiary health systems. There are few examples of fully integrated systems that span the healthcare continuum. In 2014, NorthShore University HealthSystem launched Center for Personalized Medicine to catalyze delivery medicine. Successful required development a scalable family history collection tool, Genetic Wellness Assessment (GWA) Breast Health (BHA) tools; pharmacogenomics programming;...
The accessibility of pharmacogenomic (PGx) testing has grown substantially over the last decade and with it arisen a demand for patients to be counseled on use these tests. While guidelines exist PGx results; objective determinants who should receive remain incomplete. clinical services have been created meet screening education needs significant variability exists between programs. This article describes practices four clinics during pretest counseling sessions. A description major tenets...
This article explores approaches to pharmacogenomic counseling for patients who have undergone multigene panel testing by describing the collective experience of 5 institutions.Multigene has potential unlock a myriad information about patient's past, present, and future drug response. The multifaceted nature response coupled with complexity genetic results necessitates some form patient education through counseling. Published literature regarding disclosure test is limited. compares...
Abstract The advent of next generation DNA sequencing (NGS) has revolutionized clinical medicine by enabling wide‐spread testing for genomic anomalies and polymorphisms. With that explosion in testing, however, come several informatics challenges including managing large amounts data, interpreting the results providing decision support. We present Flype, a web‐based bioinformatics platform built small group bioinformaticians working community hospital setting, to address these allowing us...
The present study builds on our prior work that demonstrated an association between pharmacogenetic interactions and 90-day readmission. In a substantially larger, more diverse population of 19,999 adults tracked from 2010 through 2020 who underwent testing with 13-gene panel, we included additional covariates to evaluate aggregate contribution social determinants medical comorbidity the presence identified gene-x-drug moderate hospital readmission (primary outcome). Univariate logistic...