A5039259069- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Fungal and yeast genetics research
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Gold and Silver Nanoparticles Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Mosquito-borne diseases and control
- Plant Virus Research Studies
- Virus-based gene therapy research
- Advanced Biosensing Techniques and Applications
- Bacteriophages and microbial interactions
- Prion Diseases and Protein Misfolding
- Heat shock proteins research
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- Urban Green Space and Health
- Trace Elements in Health
Shandong Provincial QianFoShan Hospital
2025
Shandong First Medical University
2024-2025
Sichuan University
2023-2025
Xi'an University of Technology
2025
Yanshan University
2025
State Key Laboratory of Metastable Materials Science and Technology
2025
Lanzhou University
2025
First Hospital of Lanzhou University
2025
Shandong Provincial Institute of Dermatology and Venereology
2025
Shanxi Academy of Forestry
2025
We present the design, implementation, and evaluation of a multi-sensor, low-power necklace,
Abstract A functional genomic approach integrating microarray and proteomic analyses done in our laboratory has identified 14-3-3ζ as a putative oncogene whose activation was common driven by its amplification lung adenocarcinomas. is believed to function cell signaling, cycle control, apoptotic death. Following initial finding, here, we analyzed expression tumor tissues obtained from 205 patients with various histologic stage non–small cancers (NSCLC) using immunohistochemistry then...
ABSTRACT We determined the abilities of 10 technologies to detect and quantify a common drug-resistant mutant human immunodeficiency virus type 1 (lysine asparagine at codon 103 reverse transcriptase) using blinded test panel containing mutant-wild-type mixtures ranging from 0.01% 100% mutant. Two technologies, allele-specific transcriptase PCR Ty1HRT yeast system, could down 0.1 0.4%. These should help define impact low-frequency mutants on response antiretroviral therapy.
Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to number non‐trivial practical barriers. We implemented Personalized Anti‐platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University Maryland Medical Center and Baltimore Veterans Administration Patients' are offered CYP2C19 genetic testing, which is performed in our Clinical Laboratory Improvement Amendment (CLIA)‐certified Translational...
Abstract Background Mindfulness-based cognitive therapy (MBCT) is a promising alternative treatment for generalized anxiety disorder (GAD). The objective of this study was to examine whether the efficacy group MBCT adapted treating GAD (MBCT-A) noninferior behavioural (CBT) designed treat (CBT-A), which considered one first-line treatments patients. We also explored MBCT-A in symptomatic patients compared with CBT-A variety outcomes symptoms, as well depressive overall illness severity,...
The human immunodeficiency virus type 1 (HIV-1) Vpr protein affects cell morphology and prevents proliferation of cells by induction cycle G2 arrest. In this study, we used the fission yeast Schizosaccharomyces pombe as a model system to investigate cellular effects HIV-1 vpr gene expression. was cloned into an inducible expression vector expressed in wild-type S. cells, using these were able demonstrate specific Vpr-induced suppression Induction affected at colonial, cellular, molecular...
Abstract Purpose: Analysis of molecular genetic markers in biological fluids has been proposed as a powerful tool for cancer diagnosis. We have characterized detail the signatures primary non–small cell lung cancer, which provided potential diagnostic biomarkers cancer. The aim this study was to determine whether changes can be used sputum specimen early detection Experimental Design: Genetic aberrations genes HYAL2, FHIT, and SFTPC were evaluated paired tumors samples from 38 patients with...
Significance The Zika virus (ZIKV) causes various neurologic defects including microcephaly and the Guillain-Barré syndrome. However, little is known about how ZIKV those diseases or which viral protein(s) responsible for observed cytopathic effects involved in restricted neuronal cellular growth, dysregulation of cell cycle, induction hypertrophy death. A genome-wide analysis proteins peptides was conducted using fission yeast as a surrogate host. Seven conferred NS4A-induced growth...
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has claimed over 5.5 million lives with more than 300 people infected worldwide. While vaccines are effective, the emergence of new viral variants could jeopardize vaccine protection.
Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) is an accessory that plays important role in viral pathogenesis. This pathogenic activity Vpr related part to its capacity induce cell cycle G2 arrest and apoptosis target T cells. A screening for multicopy suppressors these activities fission yeast identified heat shock 70 (Hsp70) as a suppressor Vpr-induced arrest. Hsp70 member family molecular chaperones involved innate immunity protection from environmental stress. In...
In this article, luminescent properties of gold nanoclusters (AuNCs) were studied at the single nanoparticle level and also used as novel imaging agents in cell media. Two types water-soluble AuNCs which stabilized with a monolayer composed either mercaptosuccinic acid (MSA) or tiopronin thiolate ligands synthesized by chemical reduction reaction. These determined to have an average core diameter less than 2 nm. On time-resolved confocal microscope, emission signals from distinctly...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital role in viral pathogenesis and disease 2019 (COVID-19). Like the spike protein, mutates frequently, certain variants are associated with severity of COVID-19. Given clinical significance functional implications mutations, we conducted comprehensive mutagenesis study targeting various known elements revealed two distinctive types proteins based on their subcellular localizations: primarily...
ABSTRACT Cell cycle G 2 arrest, nuclear localization, and cell death induced by human immunodeficiency virus type 1 Vpr were examined in fission yeast using a panel of mutations that have been studied previously cells. The effects the on functions highly similar between Consistent with mammalian studies, induction arrest was found to be independent localization. In addition, also shown killing, which only occurred when mutant localized nucleus. C-terminal end is crucial for N-terminal...