A5012670400- Force Microscopy Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Molecular spectroscopy and chirality
- Molecular Junctions and Nanostructures
- Heart Rate Variability and Autonomic Control
- Prostate Cancer Treatment and Research
- DNA and Nucleic Acid Chemistry
- Meteorological Phenomena and Simulations
- Thermoregulation and physiological responses
- Mechanical and Optical Resonators
- Occupational Health and Safety Management
- Endodontics and Root Canal Treatments
- Prostate Cancer Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Cutaneous Melanoma Detection and Management
- Liquid Crystal Research Advancements
- Cardiovascular and exercise physiology
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Neurological disorders and treatments
- Space Exploration and Technology
- Dental Radiography and Imaging
- Infrared Thermography in Medicine
- Optical Polarization and Ellipsometry
- Boron Compounds in Chemistry
ETH Zurich
2020-2025
Charité - Universitätsmedizin Berlin
2024
Suzuki (Japan)
2020
The University of Texas at Arlington
2014-2018
Riverbank Local Redevelopment Authority
2016-2018
University of New Mexico
1994-2016
Providence Regional Medical Center Everett
2011-2016
Roche (Switzerland)
2016
Torrance Memorial Medical Center
2009-2015
Applied Energetics (United States)
2015
The so-called True Skill Statistic (TSS) and the Heidke Score (S), as used in context of contingency, table approach to forecast verification, are compared. It is shown that TSS approaches Probability Detection (POD) whenever forecasting dominated by correct forecasts non-occurrence, i.e., rare events like severe local storms. This means vulnerable "hedging" event forecasting. S-statistic be superior this situation, accounting for null a controlled fashion. turns out S values related subtle...
Abstract Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA whole-exome sequencing the PDX organoids confirmed transcriptomic genomic similarity primary tumor. PNPCa harbors BRCA2 CHD1 somatic mutations, shows SPOP/FOXA1 -like signature microsatellite...
Microscopes have played a fundamental role in the development of biology as an experimental science. It was Robert Hooke who, when using compound microscope 1655, noticed that thin slices cork were made up identical and small self-contained units, which he called “cells.” The generalization this observation its acceptance, though, had to wait until late 1830s, German microscopists Matthias Schleiden Thcodor Schwann—working independently—introduced “cell theory” complex organisms. By second...
A theory of the polymer and salt induced (psi)-type circular dichroism observed in DNA aggregates is presented. Using main formalism developed previous paper to treat interaction light large, dense molecular aggregates, it shown that anomalously large signals certain result from: (a) presence a long-range chiral structure aggregate; (b) delocalization throughout entire particle light-induced excitations chromophores. This resulting ‘‘collective response’’ chromophores aggregate favored...
Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies urgently needed. Here, we establish human PDAC organoid biobank from 31 genetically distinct lines, covering representative range tumor subtypes, and demonstrate that these reflect molecular phenotypic heterogeneity primary tissue. We use CRISPR-Cas9 genome editing drug screening to characterize drug-gene interactions with ARID1A BRCA2. find missense- but not frameshift mutations in...
Two proteins are encoded by the mammalian retrotransposon long interspersed nuclear element 1 (LINE-1 or L1); both essential for retrotransposition. The function of protein 5'-most ORF, ORF1p, is incompletely understood, although ORF1p from mouse L1 known to bind single-stranded nucleic acids and as a acid chaperone. self-associates means coiled-coil domain in N-terminal region protein, basic, C-terminal (C-1/3 domain) contains binding activity. full-length C-1/3 domains were purified near...
A general method to describe the spectroscopy of large, internally inhomogeneous particles is presented. The theory utilizes an approach similar one used by DeVoe in treatment optical properties polymers. particle divided into groups and internal field calculated solving a self-consistent set linear equations amplitude at each group particle. It found that if dense intermediate radiation coupling mechanisms must be included addition dipole–dipole coupling. Through these it excitation...
Computations have been carried out to determine how the magnitude and shape of polymer salt induced (psi)-type CD spectra depend on structural properties a collection randomly oriented large chiral aggregates. Uniaxial polarizable groups located at cubic lattice points used model The structure is similar that cholesteric liquid crystal. All computations for case possessing only one electronic transition between 200 320 nm. It found radiation intermediate couplings chromophores in aggregate...
One hundred forty sequential patients treated for endometrial adenocarcinoma between 1958 and 1966 at Stanford University Hospital are reported. The 5-year actuarial survival the group was 75%. Tumor recurrence prognosis correlated with histologic differentiation depth of myometrial invasion. Stage I surgery alone had a 95% tumor rate 2%. Routine preoperative irradiation does not appear to be necessary or logical in treatment carcinoma. Rather, postoperative radiation should used those whose...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic models for the shapes of monolayer phospholipid crystalsHarden M. McConnell, David Keller, and Herman GaubCite this: J. Phys. Chem. 1986, 90, 8, 1717–1721Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/j100399a050https://doi.org/10.1021/j100399a050research-articleACS PublicationsRequest reuse permissionsArticle...
High-throughput screening (HTS) is essential in preclinical research to identify new drug candidates for specific diseases. This process typically generates large amounts of data that require effective storage, management, and analysis. Traditional methods handling HTS involve several standalone solutions, which can present challenges regarding accessibility reproducibility. We introduce Lab Data Management (LDM), an open-source web application developed automate the management visualization...
Abstract. Gamma-aminobutyric acid, or GABA, the major inhibitory neurotransmitter, acts both through central nervous system and via microbial production in gut. Strains able to augment gut GABA could be novel targets for modulation of sleep mood. We previously demonstrated that Lactiplantibacillus plantarum Lp815 improves symptoms anxiety. The current study investigates impact on subjective sleep, mood, digestion objective wearable data over 6 weeks adults with self-reported disturbance....
<h3>Objective.</h3> —To evaluate the safety and immunogenicity of a recombinant outer surface lipoprotein A (OspA) Lyme vaccine in healthy adults. <h3>Design.</h3> —Randomized, double-blind, placebo-controlled trial. <h3>Setting.</h3> —Clinical research unit medical center. <h3>Participants.</h3> —Thirty-six adult volunteers aged 18 through 65 years. <h3>Interventions.</h3> —Volunteers were randomly assigned to receive two 10-μg doses OspA vaccine, adsorbed alum, or buffer placebo. Subjects...
Scanning tunneling microscope images of DNA molecules absorbed onto highly oriented pyrolytic graphite have been obtained. Three methods deposition and sample preparation utilized. In the first method, a concentrated solution is sonicated, drop deposited on freshly cleaved graphite. Under these conditions, tend to align in parallel fashion, forming liquid-crystalline phases. second directly surface without sonication. this case, ammonium acetate, volatile salt, used decrease amount residual...