A5014363615- Polyomavirus and related diseases
- Energy Harvesting in Wireless Networks
- Full-Duplex Wireless Communications
- Plant Virus Research Studies
- Parvovirus B19 Infection Studies
- Animal Virus Infections Studies
- Antenna Design and Analysis
- Virus-based gene therapy research
- RNA regulation and disease
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 detection and testing
Hebei North University
2025
University of Michigan
2012-2021
Michigan United
2012
BK polyomavirus (BKPyV) is an emerging pathogen whose reactivation causes severe disease in transplant patients. Unfortunately, there no specific anti-BKPyV treatment available, and host cell components that affect the infection outcome are not well characterized. In this report, we examined relationship between BKPyV productive activation of cellular DNA damage response (DDR) natural cells. Our results showed both ataxia-telangiectasia mutated (ATM)- ATM Rad-3-related (ATR)-mediated DDR...
BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection ubiquitous the population, with over 80% of adults worldwide being seropositive for BKPyV. usually asymptomatic; however, reactivation immunosuppressed transplant patients causes two diseases, polyomavirus-associated nephropathy and hemorrhagic cystitis. To establish successful host cells, must travel retrograde transport vesicles to reach nucleus. make this happen, requires cooperation cell proteins. further...
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has become a serious global health concern due to the limited treatment options. The primary resistance mechanism in CRPA involves production of metallo-β-lactamases (MBLs), making MBL-producing P. significant component cases. To understand prevalence hospitals northern China, we conducted preliminary screening and identification 143 clinical isolates collected from various departments tertiary hospital between 2021 2023, analyzing trends...
Human polyomaviruses are emerging pathogens that infect a large percentage of the human population and excreted in urine. Consequently, urine is collected for fertilizer production often has high concentrations polyomavirus genes. We studied fate infectious double-stranded DNA (dsDNA) BK (BKPyV) hydrolyzed source-separated with infectivity assays quantitative PCR (qPCR). Although BKPyV genomes persisted long periods time (
BK polyomavirus (BKPyV) generally establishes a persistent subclinical infection in healthy individuals but can cause severe disease transplant recipients. While an vitro model to study acute replication exists, no practical with which BKPyV persistence is currently available.
We previously established an infection model for BK polyomavirus (BKPyV) in primary human renal proximal tubule epithelial (RPTE) cells. Use of these cells is limited by their inability to be passaged extensively. Here, we describe RPTE immortalized with telomerase reverse transcriptase (hTERT), which can serve as a system acute or persistent BKPyV infection.
Tools for detecting infectious human viruses in environmental samples are essential protecting health. Here, we developed an Integrated Cell Culture-Mass Spectrometry (ICC-MS) method that detects by identifying viral proteins replicate cell cultures. The ICC-MS was first validated and optimized with murine hepatitis (MHV) spiked culture media wastewater concentrates then applied to detect untreated treated samples. Reoviruses were detected when the Vero, BGMK, BSC-1 lines. Strain-specific...
Abstract BK Polyomavirus (BKPyV) is a small non-enveloped DNA virus that establishes ubiquitous, asymptomatic, and lifelong persistent infection in at least 80% of the world’s population. In some immunosuppressed transplant recipients, BKPyV reactivation causes polyomavirus-associated nephropathy hemorrhagic cystitis. We report novel vitro model persistence using natural host cell line. this system, viral genome loads remain constant for various times post-establishment infection, during...
Abstract BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection ubiquitous the population, with over 80% of adults worldwide being seropositive for BKPyV. usually asymptomatic; however, reactivation immunosuppressed transplant patients causes two diseases, polyomavirus-associated nephropathy and hemorrhagic cystitis. To establish successful its host cells, must travel retrograde transport vesicles to reach nuclei. make this happen, requires cooperation cell...
ABSTRACT We previously established an infection model for BKPyV in primary human renal proximal tubule epithelial (RPTE) cells. Use of these cells is limited by their inability to be passaged extensively. describe RPTE immortalized with hTERT, which can serve as a system acute or persistent infection.