A5074267593- Polyomavirus and related diseases
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Parvovirus B19 Infection Studies
- Full-Duplex Wireless Communications
- Bacterial Genetics and Biotechnology
- Energy Harvesting in Wireless Networks
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- RNA Research and Splicing
- Adaptive Control of Nonlinear Systems
- Reproductive System and Pregnancy
- Distributed Control Multi-Agent Systems
- Viral-associated cancers and disorders
- Stability and Control of Uncertain Systems
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Urban Transport and Accessibility
- Carbohydrate Chemistry and Synthesis
- Trace Elements in Health
- Endometriosis Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Antenna Design and Analysis
Hubei Normal University
2023-2025
Capital Medical University
2023-2025
University of Alabama at Birmingham
2014-2022
University of Michigan
2006-2013
Michigan United
2012
Universitätsklinikum Erlangen
2011
Regional West Medical Center
2010
Institut thématique Génétique, génomique et bioinformatique
2006-2007
ABSTRACT The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how tumor viruses regulate these enzymes interactions, turn, impact the integrity both viral cellular genomes. Polyomavirus (PyVs) are small pathogens that contain oncogenic potentials. In this study, we examined effects PyV infection on expression activity. We demonstrate APOBEC3B specifically upregulated by BK polyomavirus (BKPyV) primary kidney cells enzyme active....
ABSTRACT The bacterial ribosome is an extremely complicated macromolecular complex the in vivo biogenesis of which poorly understood. Although several bona fide assembly factors have been identified, their precise functions and temporal relationships are not clearly defined. Here we describe involvement Escherichia coli GTPase, CgtA E , late steps large ribosomal subunit biogenesis. belongs to Obg/CgtA GTPase subfamily, whose highly conserved members predominantly involved function....
ABSTRACT BK virus (BKV) is a nonenveloped, ubiquitous human polyomavirus that establishes persistent infection in healthy individuals. It can be reactivated, however, immunosuppressed patients and cause severe diseases, including nephropathy. The entry disassembly mechanisms of BKV are not well defined. In this report, we characterized several early events during primary renal proximal tubule epithelial (RPTE) cells, which natural host cells for BKV. Our results demonstrate RPTE involves an...
Glycosphingolipids are ubiquitous molecules composed of a lipid and carbohydrate moiety. Their main functions as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation signal transduction pathways. Microbes take advantage the different structures displayed on specific surface for attachment during infection. For some viruses, such polyomaviruses, binding to gangliosides determines internalization pathway into cells. others, interaction between microbe can...
Abstract Food turns out to be not only the nutrient supplier for our body but also a carrier of regulatory information. Interestingly, recent study made discovery that some plant/food‐derived microRNAs (miRNAs) accumulate in serum humans or plant‐feeding animals, and regulate mammalian gene expression sequence‐specific manner. The authors provided striking evidence miRNAs could function as active signaling molecules transport information across distinct species even kingdoms. Although...
ABSTRACT The bacterial response to stress is controlled by two proteins, RelA and SpoT. generates the alarmone (p)ppGpp under amino acid starvation, whereas SpoT responsible for hydrolysis synthesis of a variety cellular conditions. It widely accepted that associated with translating ribosomes. location SpoT, however, has been controversial. physically interacts ribosome-associated GTPase CgtA, we show here that, an optimized salt condition, also pre-50S particle. Analysis spoT cgtA mutants...
BK polyomavirus (BKPyV) is an emerging pathogen whose reactivation causes severe disease in transplant patients. Unfortunately, there no specific anti-BKPyV treatment available, and host cell components that affect the infection outcome are not well characterized. In this report, we examined relationship between BKPyV productive activation of cellular DNA damage response (DDR) natural cells. Our results showed both ataxia-telangiectasia mutated (ATM)- ATM Rad-3-related (ATR)-mediated DDR...
Background The role of copper in cancer treatment is multifaceted, with homeostasis-related genes associated both breast prognosis and chemotherapy resistance. Interestingly, elimination overload have been reported to therapeutic potential treatment. Despite these findings, the exact relationship between homeostasis development remains unclear, further investigation needed clarify this complexity. Methods pan-cancer gene expression immune infiltration analysis were performed using Cancer...
Biogenesis of the large ribosomal subunit requires coordinate assembly two rRNAs and 33 proteins. In vivo, additional ribosome factors, such as helicases, GTPases, pseudouridine synthetases, methyltransferases, are also critical for assembly. To identify novel ribosome-associated proteins, we used a proteomic approach (isotope tagging relative absolute quantitation) that allows semiquantitation proteins from complex protein mixtures. Ribosomal subunits were separated by sucrose density...
BK polyomavirus (BKPyV) is a widespread human pathogen that establishes lifelong persistent infection and can cause severe disease in immunosuppressed patients. BKPyV nonenveloped DNA virus must traffic through the endoplasmic reticulum (ER) for productive to occur; however, it unknown how exits ER before nuclear entry. In this study, we elucidated role of ER-associated degradation (ERAD) pathway during intracellular trafficking renal proximal tubule epithelial (RPTE) cells, natural host...
ABSTRACT BK polyomavirus (BKPyV) reactivation is associated with severe human disease in kidney and bone marrow transplant patients. The interplay between viral host factors that regulates the productive infection process remains poorly understood. We have previously reported cellular DNA damage response (DDR) activated upon lytic BKPyV its activation required for optimal replication primary epithelial cells. In this report, we set out to determine what components are responsible activating...
The APOBEC3B DNA cytosine deaminase is overexpressed in many different cancers and correlates with elevated frequencies of C-to-T C-to-G mutations 5′-TC motifs, oncogene activation, acquired drug resistance, poor clinical outcomes. mechanisms responsible for overexpression are not fully understood. Here, we show that the polyomavirus truncated T antigen (truncT) triggers through its RB-interacting motif, LXCXE, which turn likely modulates binding E2F family transcription factors to promote...
ABSTRACT BK virus (BKV) is the causative agent for polyomavirus-associated nephropathy, a severe disease found in renal transplant patients due to reactivation of persistent BKV infection. replication relies on interactions with many nuclear components, and subnuclear structures such as promyelocytic leukemia bodies (PML-NBs) are known play regulatory roles during number DNA infections. In this study, we investigated relationship between PML-NBs infection primary human proximal tubule...
To probe the cellular phenotype and biochemical function associated with G domains of Escherichia coli EngA (YfgK, Der), mutations were created in phosphate binding loop each. Neither an S16A nor S217A variant domain 1 or 2, respectively, was able to support growth engA conditional null. Polysome profiles EngA-depleted cells significantly altered, His(6)-EngA found cofractionate 50S ribosomal subunit. The variants unable complement abnormal polysome profile furthermore impacted respect vitro...
Abstract This paper studies the optimal tracking performance (OTP) of multiple‐input multiple‐output (MIMO) discrete communication constrained systems (CCSs) with fading channel and quantization constraints. An equivalent average is used to replace colored noise, gain output ports two channels consistent in first second moments. Combined spectral decomposition, co‐prime partial fractional decomposition other methods, quantitative explicit expression OTP eventually derived. The result shows...
ABSTRACT Sialylated lipids serve as cellular receptors for polyomaviruses. Using pharmacological inhibitors and cell lines derived from knockout mice, we demonstrate that Abl family tyrosine kinases are required replication of mouse polyomavirus BK virus, a human associated with allograft failure following kidney transplantation. We show decreasing kinase activity results in low levels surface ganglioside inhibition sialidase promotes virion binding the absence activity. These data provide...
Utilization of synthetic biology approaches to enhance current plastic degradation processes is crucial importance, as natural are very slow. For instance, the predicted lifetime a polyethylene terephthalate (PET) ...
Numerous host components are encountered by viruses during the infection process. While some of these structures left unchanged, others may go through dramatic remodeling processes. In this review, we summarize changes that occur small DNA virus infections, with a focus on nuclear and pathways. Although differ significantly in their genome infectious pathways, there common targets altered various viral factors. Accumulating evidence suggests processes often essential for productive...