Surface-enhanced Raman scattering (SERS) is a powerful method for detecting breast cancer-specific biomarkers due to its extraordinary enhancement effects obtained by localized surface plasmon resonance (LSPR) in metallic nanostructures at hotspots. In this research, gold nanostars (AuNSs) were used as SERS probes detect cancer biomarker very low concentrations. To end, we combined molecularly imprinted polymers (MIPs) detection layer with the of CA 15-3 point-of-care (PoC) analysis. This...

Alzheimer's disease (AD) is one of the most common forms dementia affecting millions people worldwide. Currently, an easy and effective form diagnosis missing, which significantly hinders a possible improvement patient's quality life. In this context, biosensors emerge as future solution, opening doors for preventive medicine allowing premature numerous pathologies. This work presents pioneering biosensor that combines bottom-up design approach using paper platform electrochemical...

Here, a molecularly imprinted polymer film (MIP) was prepared on the surface of disposable carbon screen-printed electrode (C-SPE) using (3-acrylamidopropyl)trimethylammonium chloride (AMPTMA) as functional monomer and cancer biomarker carbohydrate antigen 15-3 (CA 15-3) template.

The skin interstitial fluid (ISF) contains biomarkers that complement other biofluids such as blood, sweat, saliva, and urine. It can be sampled in a minimally invasive manner used either for point of care testing or real time, continuous monitoring analytes, the latter using microneedle arrays. analytes present ISF are indicative both systemic local (i.e., skin) physiology. In this paper, we describe combining technology with molecularly imprinted polymers to demonstrate potential...

Alzheimer's disease (AD) is the most common dementia type and a leading cause of death disability in elderly. Diagnosis expensive invasive, urging development new, affordable, less invasive diagnostic tools. The identification changes expression non-coding RNAs prompts tools to detect disease-specific blood biomarkers. Building on this idea, work reports novel electrochemical microRNA (miRNA) biosensor for diagnosis AD, based carbon screen-printed electrodes (C-SPEs) modified with two gold...

This work presents a novel approach for tailoring molecularly imprinted polymers (MIPs) with preliminary stage of atom transfer radical polymerization (ATRP), more precise definition the cavity. A well-defined copolymer acrylamide and N,N′-methylenebisacrylamide (PAAm-co-PMBAm) was synthesized by ATRP applied to gold electrodes template, followed crosslinking reaction. The template removed from polymer matrix enzymatic/chemical action. surface modifications were monitored via electrochemical...

The detection of glucose is crucial for diagnosing diseases such as diabetes and enables timely medical intervention. In this study, a disposable enzymatic screen-printed electrode electrochemical biosensor enhanced with machine learning (ML) quantifying in serum presented. platinum working surface was modified by chemical adsorption biographene (BGr) oxidase, the enzyme encapsulated polydopamine (PDP) electropolymerisation. Electrochemical characterisation morphological analysis (scanning...

The assessment of fish welfare is crucial to prevent economic losses in aquaculture and ensure reliable results research. A quick, non-invasive device measure cortisol levels farm water facilitates evaluation corrective actions when compromised. To address this need, an innovative sensor was developed using screen-printed carbon electrodes (SPCEs) functionalized with reduced graphene oxide/Prussian blue nanocubes (rGO/PBNCs) for direct selective detection cortisol. molecularly imprinted...

Abstract The growing demand for thermochromic materials in areas such as food packaging requires the development of fast‐response and extended‐life materials. use metal cation‐ionic liquid complexes is increasing due to easiness tailor their properties, leading changes response. This work presents synthesis introduction 1‐butyl‐3‐methylimidazolium chloride 4‐chloronickelate ([BMIm] 2 [NiCl 4 ]) into water‐based inks. Formulations with varying concentrations (10–40 wt.%) are printed on tags...

Este estudo trata do material pedagógico “Trilhas de Aprendizagens”, publicado pela Secretaria Municipal Educação São Paulo, por ocasião da pandemia Covid-19, que pertence ao arquivo municipal cidade com a finalidade ser utilizado pelos professores no processo ensino e aprendizagem. A pesquisa verifica relação os objetivos previstos para o 1º ano Ensino Fundamental currículo oficial cidade. O trabalho busca identificar quais aprendizagem Currículo Língua Portuguesa são contemplados pelas...

Web-based social media networks have an increasing frequency of health-related information, resources, and (both support professional). Although we are aware the presence these health networks, do not yet know their ability to (1) influence flow behaviors, attitudes, information (2) what resources most in shaping particular outcomes. Lastly, research community lacks easy-to-use data gathering tools conduct applied using from websites. In this position paper discuss sketch our current work on...

The security community spares no effort in emphasizing awareness and the importance of building secure software. However, number new vulnerabilities found today's systems is still increasing. Furthermore, old well-studied vulnerability types such as buffer overflows SQL injections, are repeatedly reported databases. Historically, common response has been to blame developers for their lack education. This paper discusses a hypothesis explain this problem by introducing paradigm where software...

Summary RAFT precipitation polymerization was here used for the molecular imprinting of 5‐fluorouracil (a drug in cancer treatment) followed by grafting polymer functional brushes particles surface. Materials combining high recognition capabilities and stimulation triggered changes surrounding environment (e.g. pH/temperature) have thus been sought. Mathematical modeling copolymerization vinyl/divinyl monomers to describe crosslinking process involved step. The size grafted estimated using...

A cork based point of care diagnostic device for monitoring cytokine biomarkers in biofluids.

Kernel-level key loggers, which are installed as part of the operating system (OS) with complete control kernel code, data and resources, a growing very serious threat to security current systems. Defending against this type malware means defending itself compromise it is still an open difficult problem. This paper details implementation two classical kernel-level loggers for Linux 2.6.38 how defense approaches fail protect OSes malware. We further present our research directions mitigate by...

Our society is dependent upon computer systems that are the target of a never-ending siege against their resources. One powerful avenue for exploitation operating system kernel, which has complete control system's The current methodology kernel design, involves loadable extensions from third parties, facilitates compromises. Most these benign, but in general they pose threat to trustworthiness: run as part and some them can be vulnerable or malicious. This situation paradoxical security...

Kernel extensions, especially device drivers, make up a large fraction of modern OS kernels (approximately 70% in Linux). Most extensions are benign and represent convenient approach for extending the kernel functionality allowing system to communicate with an increasing number I/O devices. A small them malicious and, as they run space, pose threat integrity. From security viewpoint this situation is paradoxical: OSes depend must co-live untrustworthy but needed extensions. Our immune faces...

The increasing acquisition of companion animals associated with reproductive uncontrolled behavior and abandonment reveal that the lack responsibility for can pose risks to public health. Thus, this study consisted evaluating knowledge Seropédica community about zoonoses, population control responsible ownership animals. To end, aspects underlie were assessed through a structured questionnaire applied 417 guardians during anti-rabies vaccination campaign dogs cats in city Seropédica, RJ....

A síndrome de Burnout foi definida por um psiquiatra em 1974 e atualmente tem sido muito discutida médicos veterinários. O está relacionado ao esgotamento físico emocional, gerando problemas saúde transtorno ansiedade profissionais que são sobrecarregados suas tarefas. objetivo deste estudo é mostrar a relevância medidas possam minimizar pressão induzida pelas responsabilidades da área saúde, através do “EntreteniPET”, projeto criado pelo grupo PET Medicina Veterinária, busca meio atividades...