A5073175627- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Barrier Structure and Function Studies
- Ion Transport and Channel Regulation
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Neurological Disease Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
University of Colorado Anschutz Medical Campus
2024
Goethe University Frankfurt
2017-2021
University Hospital Frankfurt
2020
Septic encephalopathy with confusion and agitation occurs early during sepsis contributes to the severity of disease. A decrease in sphingosine-1-phosphate (S1P) blood levels has been shown patients animal models sepsis. The lipid mediator S1P is known be involved endothelial barrier function a context-dependent manner. We utilized lipopolysaccharide (LPS)-injected mice as model for septic first performed tracer permeability assays assess blood-brain (BBB) breakdown vivo. At time points...
With increasing distribution of endovascular stroke therapies, transient middle cerebral artery occlusion (tMCAO) in mice now more than ever depicts a relevant patient population with recanalized M1 occlusion. In this case, the desired therapeutic effect blood flow restauration is accompanied by breakdown blood-brain barrier (BBB) and secondary reperfusion injury. The aim study was to elucidate short intermediate-term transcriptional patterns involved pathways covering different cellular...
The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate (S1P), a lipid signaling molecule enriched in plasma, known affect BBB permeability. Previous studies focused on endothelial S1P receptors 1 2, reporting barrier-protective effect S1P1 barrier-disruptive S1P2. Here, we present novel data characterizing the expression, localization, function receptor 4 (S1P4) primary...