A5015506615- T-cell and B-cell Immunology
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Preterm Birth and Chorioamnionitis
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Pregnancy-related medical research
Instituto Politécnico Nacional
2020
Universidad Autónoma del Estado de Morelos
2016-2019
To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that their adult counterparts. We found lymphocytes have distinct epigenomic landscape associated lower genes involved in cell receptor (TCR) signaling cytotoxicity higher the cycle innate immunity. Functional studies corroborated are less cytotoxic, transcribe antimicrobial peptides, produce reactive oxygen...
During pregnancy, NF-κB plays an important role for embryo implantation and the onset of labor. Regulated IL-6 production, under transcriptional control NF-κB, is essential a successful pregnancy outcome atypical regulator IκBNS involved in this process. Previously, we showed that negatively regulates uterine tissues during mouse estrous cycle. In work, analyzed if expression pregnant mice physiological or L. monocytogenes-infected conditions would remain as observed healthy was highly...
The canonical Wnt signaling pathway is a master cell regulator involved in CD8+ T proliferation and differentiation. In human cells, this induces differentiation into memory cells or "stem like" population, which preferentially present cord blood. To better understand the role of signals neonatal adult blood, we compared proteins associated with β-catenin, nonstimulated Wnt3a-stimulated naive cells. Differentially recruited established different complexes former, β-catenin-associated were...