A5101631833- Parasites and Host Interactions
- Single-cell and spatial transcriptomics
- Planarian Biology and Electrostimulation
- Genomics and Phylogenetic Studies
- Parasite Biology and Host Interactions
- Cell Image Analysis Techniques
- Cancer therapeutics and mechanisms
- Plant biochemistry and biosynthesis
- Microbial Community Ecology and Physiology
- Evolution and Genetic Dynamics
- Parasitic Diseases Research and Treatment
- Laser Applications in Dentistry and Medicine
- dental development and anomalies
- Plant tissue culture and regeneration
- Heavy metals in environment
- Gut microbiota and health
- Recycling and utilization of industrial and municipal waste in materials production
- Advanced biosensing and bioanalysis techniques
- Adsorption and biosorption for pollutant removal
- Macrophage Migration Inhibitory Factor
- Plant Disease Resistance and Genetics
- Marine Invertebrate Physiology and Ecology
- Insect Resistance and Genetics
- Protist diversity and phylogeny
- Effects and risks of endocrine disrupting chemicals
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023-2025
China Academy of Chinese Medical Sciences
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
University of California, San Francisco
2023-2024
Zhejiang Chinese Medical University
2023-2024
Stanford University
2017-2023
Cedars-Sinai Medical Center
2023
Jilin University
2021-2022
Bioengineering Center
2018-2021
Facing Our Risk of Cancer Empowered
2021
Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the origins of cellular diversity and assist annotation new cell atlases. Yet, comparison between distant relatives is hindered by complex gene histories diversifications in expression programs. Previously, we introduced self-assembling manifold (SAM) algorithm to robustly reconstruct manifolds data (Tarashansky et al., 2019). Here, build on SAM map atlas across species. This method, SAMap, identifies...
Schistosomes are parasitic flatworms infecting hundreds of millions people. These parasites alternate between asexual reproduction in molluscan hosts and sexual mammalian hosts; short-lived, water-borne stages infect each host. Thriving such disparate environments requires remarkable developmental plasticity, manifested by five body plans deployed throughout the parasite's life cycle. Stem cells Schistosoma mansoni provide a potential source for plasticity; however, relationship stem from...
Single-cell RNA sequencing has spurred the development of computational methods that enable researchers to classify cell types, delineate developmental trajectories, and measure molecular responses external perturbations. Many these technologies rely on their ability detect genes whose cell-to-cell variations arise from biological processes interest rather than transcriptional or technical noise. However, for datasets in which biologically relevant differences between cells are subtle,...
Abstract Schistosomes are parasitic flatworms causing one of the most prevalent infectious diseases from which millions people currently suffering. These parasites have high fecundity and their eggs both transmissible agents cause infection-associated pathology. Given its biomedical significance, schistosome germline has been a research focus for more than century. Nonetheless, molecular mechanisms that regulate development only now being understood. In particular, it is unknown what...
Heavy metals often coexist in contaminated environmental media, and competition between heavy for adsorption sites influences the absorption capacity of biochar. In this study, mechanism pyrolytically modified wood ear mushroom sticks (250, 450, 650 °C) as a new bio-adsorbent single-ion mixed-ion solutions Cd2+ Pb2+ Biochar experiments showed that abilities increased with increasing WMBC (wood biochar) pyrolysis temperature. According to Langmuir model, maximum Pb2+increased higher...
Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for treatment dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated mechanism underlying its metabolic action. Here, liquid chromatography-mass spectrometry (LC-MS)-based metabolomic techniques were utilized to characterize in vivo effects decoction achieving reduction levels and understand potential mechanisms action.We constructed DPDRS animal model...
Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing though clinical trials to market. Identification single compounds active against multiple parasitic pathogens could improve incentives as well simplifying treatment regimens. We recently performed screen repurposed protozoan parasite Entamoeba histolytica, causative agent amebic dysentery, identified...
Cell types evolve into a hierarchy with related grouped families. How cell type diversification is constrained by the stable separation between families over vast evolutionary times remains unknown. Here, integrating single-nucleus multiomic sequencing and deep learning, we show that hundreds of sequence features (motifs) divide distinct sets associated accessible genomes specific This division conserved across highly divergent, early-branching animals including flatworms cnidarians. While...
An unmet challenge in the study of disease is to accurately streamline identification important virulence factors. Traditional, genetically driven approaches miss biologically relevant markers due discordance between genome and proteome. Here, we developed a nanotechnology-enabled affinity enrichment strategy coupled with multiplexed quantitative proteomics, namely Biomimetic Virulomics, for successful cell-type specific effector proteins both prokaryotic eukaryotic pathogens. We highlight...
Transcription factors (TFs) of plant-specific SHORT INTERNODES (SHI) family play a significant role in regulating development and metabolism plants. In Artemisia annua, various TFs from different families have been discovered to regulate the accumulation artemisinin. However, specific members SHI A. annua (AaSHIs) not identified biosynthesis
Abstract Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the origins of cellular diversity and assist annotation new cell atlases. Yet, comparison between distant relatives is hindered by complex gene histories diversifications in expression programs. Previously, we introduced self-assembling manifold (SAM) algorithm to robustly reconstruct manifolds data (Tarashansky et al., 2019). Here, build on SAM map atlas across species. This method, SAMap, identifies...
Injury induces systemic, global responses whose functions remain elusive. In addition, mechanisms that rapidly synchronize wound through long distances across the organismal scale are mostly unknown. Using planarians, which have extreme regenerative ability, we report injury Erk activity to travel in a wave-like manner at an unexpected speed (∼1 mm/h), 10-100 times faster than those measured other multicellular tissues. This ultrafast signal propagation requires longitudinal body-wall...
Abstract Single-cell RNA sequencing has spurred the development of computational methods that enable researchers to classify cell types, delineate developmental trajectories, and measure molecular responses external perturbations. Many these technologies rely on their ability detect genes whose cell-to-cell variations arise from biological processes interest rather than transcriptional or technical noise. However, for datasets in which biologically relevant differences between cells are...
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<title>Abstract</title> Background Transcription factors (TFs) of plant-specific SHORT INTERNODES (SHI) family play a significant role in regulating development and metabolism plants. In <italic>Artemisia annua</italic>, various TFs from different families have been discovered to regulate the accumulation artemisinin. However, specific members SHI <italic>A. annua</italic> (AaSHIs) not identified biosynthesis Results We found five <italic>AaSHI</italic> genes (<italic>AaSHI1</italic>...