A5036582675- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Antibiotic Use and Resistance
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- HIV/AIDS drug development and treatment
- Infectious Diseases and Tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- Cytomegalovirus and herpesvirus research
- Urinary Tract Infections Management
- Infections and bacterial resistance
- Bladder and Urothelial Cancer Treatments
- Infectious Disease Case Reports and Treatments
- Cardiac Arrhythmias and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Peripheral Neuropathies and Disorders
- Infection Control and Ventilation
- Genital Health and Disease
- Urinary and Genital Oncology Studies
Hospital Padre Américo
2025
Centro Hospitalar do Tâmega e Sousa
2022-2025
Hospital de São João
2016-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Universidade do Porto
2015-2024
Istanbul University-Cerrahpaşa
2024
Ovidius University
2024
Instituto Nacional de Engenharia Biomédica
2016-2017
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2017
Centro Hospitalar do Porto
2014
Background . This study aims to describe the characteristics of tuberculosis (TB) patients requiring intensive care and determine in-hospital mortality associated predictive factors. Methods Retrospective cohort all TB admitted ICU Infectious Diseases Department Centro Hospitalar de São João (Porto, Portugal) between January 2007 July 2014. Comorbid diagnoses, clinical features, radiological laboratory investigations, outcomes were reviewed. Univariate analysis was performed identify risk...
This study aimed to describe the epidemiology, clinical presentation, and management of Campylobacter sp. Salmonella infections in a tertiary hospital Northern Portugal (2010–2020) identify factors associated with reporting, invasive disease, hospitalization. A retrospective review included patients (2015–2020) or (2010–2020). Reported cases were cross-referenced National Epidemiological Surveillance System. total 742 included: 342 sp., 392 non-typhoidal (NTS), 15 typhoidal (TS)....
Recurrent urinary tract infections (UTIs) in elderly patients with comorbidities can present diagnostic challenges. Extrapulmonary tuberculosis, particularly urogenital is a rare but important cause of persistent genitourinary symptoms. We describe the case an 83-year-old female hypertension, diabetes, chronic kidney disease, and obesity who was repeatedly hospitalized for UTIs. In December 2023, she presented progressive weakness, suprapubic pain, altered urine despite prior antibiotic...
Third-generation cephalosporins are widely used due to the convenient spectrum of activity, safety, and posology. However, they associated with emergence multidrug-resistant organisms, which makes them important targets for antimicrobial stewardship interventions. We aimed assess appropriateness empirical prescriptions ceftriaxone in a tertiary hospital. This cross-sectional study analysed January June 2021. Patients under other antimicrobials 48 h before admission were excluded. The quality...
Artemisinin-based therapy is the current standard treatment for non-severe malaria due to Plasmodium falciparum. The potential asymptomatic liver toxicity of this and its implication in clinical practice currently unknown. aim study assess hepatic function patients treated with a three-day artemisinin-based regimen compare it quinine-doxycycline regimen. Retrospective comparative returned adult travellers admitted P. falciparum malaria. Fifty-seven were included: 19 38 therapy. During...
Background In complicated endovascular infections by methicillin-resistant Staphylococcus aureus (MRSA) or epidermidis (MRSE), when first-line therapy with vancomycin (VAN) daptomycin (DAP) fails, combination ceftaroline (CFT) and DAP has been shown to be a useful approach as salvage for persistent MRSA bacteremia. Objectives This study aimed describe experience in MRSE-complicated infections. Methods A single-center retrospective review of consecutive patients treated ≥72 hours DAP+CFT at...
CD4 cell-count has been regarded as the key surrogate marker for prognostic staging and therapeutic monitoring of HIV-infected individuals. Our purpose was to assess probability maintaining a count >200 cells/μL in patients with continuous viral suppression cell counts cells/μL.Retrospective cohort study patients, treatment naïve, who started antiretroviral therapy between 2007 2011. We estimated during using Kaplan-Meier method. The hazard ratios <200 were compared Cox proportional hazards...
Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression. We report case PA young patient after pleurodesis for recurrent pneumothorax. Clinical resolution was achieved with systemic local antifungal therapy combined surgical debridement. Hepatotoxicity led switch from voriconazole isavuconazole, successful outcome.
Cytomegalovirus (CMV) reactivation with neurological involvement in patients acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case disseminated CMV disease gastrointestinal and peripheral central nervous system patient AIDS, manifesting primarily as MNM. A 31-year old woman AIDS presented clinical...
Ralstonia mannitolilytica (R. mannitolilytica.) is an emerging aerobic Gram-negative bacteria causing infection among immunocompromised patients. R. mannitolilytica, has been described in hospital outbreaks, mainly as bloodstream infection, but also meningitis, hemoperitoneum and post renal transplant infection. We describe the first reported case of infective endocarditis.
Q fever is a worldwide zoonotic infection caused by the obligate intracellular bacterium Coxiella burnetii that can course with acute or chronic disease. This series describes 7 cases of admitted in Portuguese University Hospital between 2014 and 2015. All presented hepatitis had epidemiological history. Diagnosis was done PCR on majority (5) serology only 2. Serological tests be negative initial period Molecular biology methods polymerase chain-reaction are extremely important disease,...
Corynebacterium striatum is an emerging Gram-positive bacillus associated with invasive infection in both immunocompetent and immunocompromised patients, especially medical devices. Its ability to form biofilms has been demonstrated it occasionally cardiac device-related infective endocarditis few cases described literature. We report a case of C. complex management.
Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) severe musculoskeletal infections. Epidemiology underknown underdiagnosis likely. Recent travel abroad, case clustering disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, found 21 over a 43-month period. Most patients were adult males, had relevant history, reported recurrent...
To assess whether electronic records data could improve the efficiency, exhaustiveness, and representativeness of SSI surveillance by selecting a group high-risk patients for manual review.Colorectal surgeries (2016-2018) cholecystectomies (2017-2018) were selected. Post-surgical antibiotic use, positive culture, C-reactive protein (CRP) values, body temperature, leukocyte count, surgical re-intervention, admission to emergency room, hospital readmission retrieved. For representativeness,...
KPC-producing K pneumoniae (KPC-Kp) is a public health problem with important clinical and epidemiological implications. We describe an outbreak of KPC-Kp at vascular surgery neurosurgery wards in central hospital Porto, Portugal.A case was considered to be patient positive for strong plausibility having acquired this microorganism the affected and/or genetic relationship ≥92% between isolates. Active surveillance cultures (ASCs) real-time polymerase chain reaction were used detection...
Introduction Distribution of HIV‐1 subtypes is variable around the world, with most common subtype in western Europe being B. The aim our study was to describe prevalence different newly diagnosed patients and identify demographic epidemiological characteristics related subtypes. Materials Methods Retrospective single‐centre infection between 2006 2012. Epidemiological data gathered genotyping performed each patient identified. Demographic were compared B other Continuous variables...
Ceftazidime/avibactam combines ceftazidime with a new beta-lactam that successfully inhibits Amber Class A and D carbapenemases. We report clinical case of 61 year-old man carbapenemase-producing Klebsiella pneumoniae intra-abdominal infection after an elective abdominal hernia repair. The was managed multiple surgeries, drainage combined antibiotic therapy ceftazidime/avibactam plus tigecycline.
There is a large reservoir of individuals with past hepatitis B virus (HBV) infection that are in risk for HBV reactivation when immunosuppressed. On the setting hematologic malignancy, malignancy itself and currently used treatments, especially anti-CD20 agents, have reactivation. Antiviral prophylaxis recommended by some international societies. We present case more than 12 months after stopping rituximab containing treatment 6 antiviral entecavir, patient functional cure. The was...
Neisseria meningitidis is a gram-negative diplococcus which causes invasive disease. The most frequent clinical manifestations caused by infection with this pathogen, are meningitis and fulminant septic shock. More benign forms subacute or chronic pattern rare but still can evolve to have fatal outcome. This entity difficult recognize, as febrile erythema otherwise good general condition may simulate other diseases, namely viral infections. authors reported the cases of two healthy young...
Introduction Presence of viral mutations conferring resistance to antiretroviral drugs has potential impact on success therapy (ART). The aim this study was describe the prevalence resistance‐associated in HIV‐infected patients without prior ART a Portuguese cohort. Materials and Methods Retrospective single‐centre newly diagnosed with HIV‐1 infection between 2006 2012. Resistance genotyping obtained HIV TRUGENE ® Viroseq tests analysis drug based Stanford University Drug Database....
To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify factors associated in-hospital mortality in an ICU Portugal.