A5055908262- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Colorectal Cancer Treatments and Studies
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Genomics and Rare Diseases
- Bacteriophages and microbial interactions
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
Vilnius University
2015-2023
Macroautophagy (hereafter autophagy) is one of the adaptive pathways that contribute to cancer cell chemoresistance. Despite fact autophagy can both promote and inhibit death, there mounting evidence in context anticancer treatment, it predominantly functions as a survival mechanism. Therefore, silencing key genes emerges potent strategy reduce Though importance chemoresistance established, changes case acquired are poorly understood. In this study, we aimed determine cellular model...
Abstract The protein sequestosome 1 (p62/SQSTM1) is primarily known as a selective autophagy cargo receptor, but due to its multidomain structure, it also has roles in the ubiquitin‐proteasome system, metabolism, cell death and survival signalling. increase p62 levels detected some types of cancers, including colorectal cancer (CRC). Chemoresistance main cause high mortality rates CRC patients. Since can regulate both death, potential modulator chemoresistance. impact on molecular causes...
Bionanoparticles comprised of naturally occurring monomers are gaining interest in the development novel drug transportation systems. Here we report on stabilisation, cellular uptake, and macrophage clearance nanotubes formed from self-assembling gp053 tail sheath protein vB_EcoM_FV3 bacteriophage. To evaluate potential bacteriophage protein-based as therapeutic nanocarriers, investigated their internalisation into colorectal cancer cell lines professional macrophages that may hinder...
Background and Objectives: Heterozygous pathogenic variants in the MED13L gene cause impaired intellectual development distinctive facial features with or without cardiac defects (MIM #616789). This complex neurodevelopmental disorder is characterised by various phenotypic features, including plagiocephaly, strabismus, clubfoot, poor speech, developmental delay. The aim of this study was to evaluate clinical significance consequences a novel heterozygous intragenic deletion proband...