A5002242579- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Air Quality and Health Impacts
- Chromium effects and bioremediation
- Animal testing and alternatives
- Heavy Metal Exposure and Toxicity
- Chemistry and Chemical Engineering
- Health, Environment, Cognitive Aging
- Adsorption and biosorption for pollutant removal
- Pesticide and Herbicide Environmental Studies
- Per- and polyfluoroalkyl substances research
- Pesticide Residue Analysis and Safety
- Environmental remediation with nanomaterials
- Acute Lymphoblastic Leukemia research
- Computational Drug Discovery Methods
- Environmental Justice and Health Disparities
- Heavy metals in environment
- Pharmacogenetics and Drug Metabolism
- Analytical chemistry methods development
- Environmental Toxicology and Ecotoxicology
- Water Treatment and Disinfection
- Inhalation and Respiratory Drug Delivery
- Advanced Chemical Sensor Technologies
Summit School
2014-2024
University of Alabama
2019-2023
Corteva (United States)
2021
Manhattan College
2019
University of Wisconsin–Milwaukee
2019
Arizona State University
2019
University of Illinois Urbana-Champaign
2019
University of Wisconsin–Madison
2019
University of Washington
2019
Brookhaven National Laboratory
2014
Based on existing data and previous work, a series of studies is proposed as basis toward pragmatic early step in transforming toxicity testing. These were assembled into data-driven framework that invokes successive tiers testing with margin exposure (MOE) the primary metric. The first tier integrates from high-throughput vitro assays, vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, modeling. assays are used to separate chemicals based their relative selectivity interacting...
Background: Biomonitoring data reported in the National Report on Human Exposure to Environmental Chemicals [NER; Centers for Disease Control and Prevention (2012)] provide information presence concentrations of > 400 chemicals human blood urine. Equivalents (BEs) other risk assessment–based values now allow interpretation these biomonitoring a public health context.Objectives: We compared measured biomarker NER with BEs similar assessment an across-chemical perspective levels approximately...
High concentrations of hexavalent chromium [Cr(VI)] in drinking water induce villous cytotoxicity and compensatory crypt hyperplasia the small intestines mice (but not rats). Lifetime exposure to such cytotoxic increases intestinal neoplasms mice, suggesting that mode action for Cr(VI)-induced tumors involves chronic wounding cell proliferation intestine. Therefore, we developed a oral reference dose (RfD) designed be protective damage thus cancer. A physiologically based pharmacokinetic...
Background:Urinary analyte concentrations are affected both by exposure level and urinary flow rate (UFR). Systematic variations in UFR with demographic characteristics or body mass index (BMI) could confound assessment of associations between health outcomes biomarker concentrations.Objectives:We assessed patterns (milliliters per hour) weight–adjusted (UFRBW; milliliters kilogram across age, sex, race/ethnicity, BMI category the NHANES (National Health Nutrition Examination Survey)...
Physiologically based pharmacokinetic (PBPK) models are used in mode-of-action risk and safety assessments to estimate internal dosimetry animals humans. When assessment, these can provide a basis for extrapolating between species, doses, exposure routes or justifying nondefault values uncertainty factors. Characterization of variability is increasingly recognized as important assessment; this represents continuing challenge both PBPK modelers users. Current practices show significant...
Population biomonitoring data sets such as the Canadian Health Measures Survey (CHMS) and United States National Nutrition Examination (NHANES) collect analyze spot urine samples for analysis biomarkers of exposure to non-persistent chemicals. Estimation population intakes using in a risk-assessment context requires consideration intra- inter-individual variability understand relationship between variation biomarker concentrations underlying daily longer-term intakes. Two intensive with...
The field of precision medicine has undergone significant growth over the past 10 years. Despite increasing applications clinical genetic and genomic testing, studies consistently report limited knowledge genetics genomics among healthcare providers. This study explored barriers to implementation by surveying physicians working in a large academic medical center. We assessed prior training genetics, use testing clinic, desire for additional resources perceived successful integration...
An expert panel was convened to provide insight and guidance on per- polyfluoroalkyl substances (PFAS) grouping for the purposes of protecting human health from drinking water exposures, how risks PFAS mixtures should be assessed. These questions were addressed through multiple rounds blind, independent responses charge questions, review comments co-panelists responses. The experts agreed that lack consistent interpretations risk well-studied information vast majority present significant...