A5058438032- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Animal testing and alternatives
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Chemical Safety and Risk Management
- Computational Drug Discovery Methods
- Noise Effects and Management
- Epigenetics and DNA Methylation
- Environmental Justice and Health Disparities
- Climate Change and Health Impacts
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Gene expression and cancer classification
- Neurological Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Environmental Toxicology and Ecotoxicology
- Chemistry and Chemical Engineering
- Risk and Safety Analysis
- Child Nutrition and Water Access
- Neurogenesis and neuroplasticity mechanisms
- Atmospheric chemistry and aerosols
- Cephalopods and Marine Biology
Colorado School of Public Health
2023
Environmental Protection Agency
2007-2020
Research Triangle Park Foundation
1987-2020
National Center for Environmental Assessment (EPA)
2007-2020
Triangle
2020
Boulder Neurosurgical & Spine Associates
2018
University of New Mexico
1975-1978
West Virginia University
1976
Based on existing data and previous work, a series of studies is proposed as basis toward pragmatic early step in transforming toxicity testing. These were assembled into data-driven framework that invokes successive tiers testing with margin exposure (MOE) the primary metric. The first tier integrates from high-throughput vitro assays, vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, modeling. assays are used to separate chemicals based their relative selectivity interacting...
The number of legacy chemicals without toxicity reference values combined with the rate new chemical development is overwhelming capacity traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate risks. In this study, rats were dosed orally multiple doses six for 5 days and 2, 4, 13 weeks. Target organs analyzed histological organ weight changes transcriptional using microarrays. Histological in study tumor incidences original cancer bioassays...
Objectives: In 2011, the U.S. Environmental Protection Agency initiated NexGen project to develop a new paradigm for next generation of risk science.Methods: The framework was built on three cornerstones: availability data toxicity pathways made possible by fundamental advances in basic biology and toxicological science, incorporation population health perspective that recognizes most adverse outcomes involve multiple determinants, renewed focus assessment methodologies designed better...
Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component risk assessment process. At workshop held in Baltimore, Maryland, on 23-24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences Public Policy Institute, multidisciplinary group experts reviewed state science regarding low-dose modeling its application assessments. Participants identified discussion topics based literature review,...
Over the past 20 years, knowledge of genome and its function has increased dramatically, but risk assessment methodologies using such have not advanced accordingly.This commentary describes a collaborative effort among several federal state agencies to advance next generation assessment. The objective NexGen program is begin incorporate recent progress in molecular systems biology into practice. ultimate success this will be based on incorporation new practices that facilitate faster,...
Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues adopt molecular systems biology technologies. Systematic screening reviews can help assessment teams determine which studies consider for inclusion in a human assessment. A tool systematic should be standardized transparent order consistently meet minimum quality criteria prior performing in-depth analyses data. The Omics Analysis Review (SOAR) is focused on...
Summary Male rats (N = 27) were given initial experience with escapable shock, equivalent amounts of inescapable or no shock. Measures then obtained in the ensuing 15 hours on food intake, water number cage crossings, and weight change for all groups. Following this, animals tested an escape task. Inescapably shocked showed significant decreases consumption comparison to both nonshocked escapably control rats. Weight gains significantly decreased by exposure shock irrespective availability a...
The effects of barbiturates on responses to iontophoretically applied acetylcholine and gamma-aminobutyric acid were studied in Aplysia californica by using a voltage clamp. Dose-response data obtained for barbiturate concentrations ranging from 1 microM 3 mM. Both phenobarbital pentobarbital depress chloride-dependent inhibitory both acid. This depression occurs at approximately the same which attenuate excitatory responses. Potassium-dependent minimally affected. In case was enhancement...
This paper describes the use of multiple models and model averaging for considering dose-response uncertainties when extrapolating low-dose risk from studies populations with high levels exposure. The approach we applied builds upon innovative methods developed by U.S. Food Drug Administration (FDA), principally through relaxing constraints. constraints allowed us to evaluate uncertainty using a broader set forms and, within context averaging, did not result in extreme supralinearity that is...