A5101556652- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Fluoride Effects and Removal
- Glutathione Transferases and Polymorphisms
- Environmental Justice and Health Disparities
- Genetics, Aging, and Longevity in Model Organisms
- Multiple and Secondary Primary Cancers
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Water Treatment and Disinfection
- Ovarian cancer diagnosis and treatment
- Acute Lymphoblastic Leukemia research
- Nutritional Studies and Diet
- Cancer Research and Treatments
- Environmental and Cultural Studies in Latin America and Beyond
- Radiomics and Machine Learning in Medical Imaging
- Urinary and Genital Oncology Studies
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Coffee research and impacts
Division of Cancer Epidemiology and Genetics
2002-2023
National Cancer Institute
2021-2023
National Cancer Institute
2006-2022
Gilead Sciences (United States)
2022
National Institutes of Health
2007-2012
Science Applications International Corporation (United States)
2002-2012
Maine Medical Center
2012
Dartmouth College
2012
University of Vermont
2012
Vermont Cancer Support Network
2012
It is increasingly common for computer users to have access several computers on a network, and hence be able execute many of their tasks any computers. The choice which commonly determined by based knowledge speeds each task the current load computer. A number scheduling systems been developed that balance but such tend minimize idle time rather than users. paper focuses benefits can achieved when system considers both availabilities performance SmartNet resource described compared two...
From 1958 to 1970, >100,000 people in northern Chile were exposed a well-documented, distinct period of high drinking water arsenic concentrations. We previously reported ecological evidence suggesting that early-life exposure this population resulted increased mortality adults from several outcomes, including lung and bladder cancer.
Inorganic arsenic (In-As), an occupational and environmental human carcinogen, undergoes biomethylation to monomethylarsonate (MMA) dimethylarsinate (DMA). It has been proposed that saturation of methylation capacity at high exposure levels may lead a threshold for the carcinogenicity In-As. The relative distribution urinary In-As, MMA, DMA is used as measure capacity. most common pathway elevated In-As worldwide through drinking water. We conducted biomarker study in northern Chile...
Abstract BACKGROUND: When epithelial ovarian cancer is detected at an early stage (I‐II), the 5‐year survival rate between 70% and 90%; whereas, when it in late stages (III‐IV), slips to <30%. In a previous report, authors observed that proteomic biomarkers antigen 125 (CA 125) exhibited sensitivity of 84% specificity 98% for identifying sera from patients who had I disease time surgery, significantly improving CA alone. The challenge, however, detect before clinical diagnosis. current...
We investigated the evidence of a familial contribution to urinary methylation patterns in families ingesting arsenic drinking water. Arsenic can be assessed by measuring levels inorganic (InAs) and its methylated metabolites, monomethylarsonate (MMA), dimethylarsinate (DMA). Methylation activity is reflected ratios: InAs/methylated (InAs/metAs) MMA/DMA. Eleven from Chile were selected because their long-term exposure very high water (735-762 microg/L). Each family consisted father, mother,...
The authors examined the role of diet in high-risk population Central Europe among 1,065 incident kidney cancer cases and 1,509 controls Russia, Romania, Poland, Czech Republic. They observed an increased association with for consumption milk (odds ratio (OR) = 1.46, 95% confidence interval (CI): 1.15, 1.84) yogurt (OR 1.34, CI: 1.07, 1.67), as well all meat 1.27, 1.06, 1.51 compared lowest tertile). High vegetables 0.64, 0.51, 0.80) cruciferous 0.68, 0.55, 0.84) was inversely associated...
Inorganic arsenic exposure through drinking water causes cancer in adults; however, the carcinogenic potential children remains unknown. A recent leukemia cluster Churchill County, Nevada, where levels supplies are relatively high, has prompted concern. The authors investigated incidence of childhood between 1979 and 1999 all 17 Nevada counties, grouped by low (i.e., < 10 microg/l), medium (10-25 high (35-90 microg/l) population-weighted public supplies. standardized ratios (SIRs) for...
Ingestion of arsenic (As) through contaminated drinking water results in increased risks skin, lung, kidney, and bladder cancers. Due to its association with kidney cancers, we hypothesized that analysis the urinary proteome could provide insight into mechanisms As toxicity. Urine from participants a cross-sectional biomarker study conducted Nevada, classified as having either high (≥ 100 μg total As/l) or low exposure (< was analyzed by surface-enhanced laser desorption/ionization...
Abstract Background: Cell-cycle proteins are important predictive markers in urothelial carcinoma but may also exhibit exposure-specific heterogeneity. Methods: Tumor tissue from 491 bladder cancer cases enrolled the Maine and Vermont component of New England Bladder Cancer Study was assembled as microarrays examined for aberrant expression p53, p63, p16, cyclin D1, Rb, Ki-67. The association between histopathology, demographics, cigarette smoking using χ2 tests, multivariable Poisson,...
Objective: This article assesses the cost-effectiveness of outpatient antimicrobial treatment community-acquired pneumonia (CAP) taking into account resistance in Belgium.Research design and methods: Our decision analytic model focused on mild to moderate CAP, but did not consider severe CAP. Treatment pathways reflected empirical initiated absence data CAP aetiology. First-line consisted moxifloxacin, co-amoxiclav, cefuroxime or clarithromycin. If first-line was unsuccessful, patients were...
We conducted a large death certificate-based case-control study to assess occupational risks for salivary gland cancer. African American (168 cases, 672 controls) and white (2237 8748 cases from 24 states (1984–1989) were matched controls by age, sex, race, region. Race- sex-stratified multiple logistic regression models calculated adjusted odds ratios. The proportion of young (<50 years) was greatest among Americans (20.8% vs. 8.8%). Higher socioeconomic status, ionizing radiation,...
Objective The aim of this study was to investigate whether risk estimates for childhood acute lymphoblastic leukemia change when restricting model comparison groups “nonpesticide exposure” (NPE10) households. Methods Cases ( n = 1810) 15 years or younger were identified through Children's Cancer Group institutions between 1989 and 1993 age-/sex-matched controls 1951). Household pesticide use during pregnancy/month prior collected via telephone. NPE10 group reporting no parental exposure 10...
Abstract Background: In ASCENT, patients with mTNBC refractory to or relapsing after ≥2 prior chemotherapies (at least one in the metastatic setting) were randomized 1:1 receive sacituzumab govitecan (SG) single-agent treatment of physician’s choice (TPC) (capecitabine, eribulin, vinorelbine, gemcitabine). Primary endpoint was progression free survival. Secondary endpoints included overall survival, objective response rate, clinical benefit and safety. Here we examined whether health-related...