A5101830425- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Advanced Battery Technologies Research
- Minerals Flotation and Separation Techniques
- Advanced Photocatalysis Techniques
- CO2 Sequestration and Geologic Interactions
- Gas Sensing Nanomaterials and Sensors
- Monoclonal and Polyclonal Antibodies Research
- Metal Extraction and Bioleaching
- Electrocatalysts for Energy Conversion
- Water Quality Monitoring and Analysis
- Calcium Carbonate Crystallization and Inhibition
- TiO2 Photocatalysis and Solar Cells
- Iron oxide chemistry and applications
- Advanced oxidation water treatment
- Extraction and Separation Processes
- Metallurgy and Material Forming
- Adaptive Control of Nonlinear Systems
- Mine drainage and remediation techniques
- Electrochemical Analysis and Applications
Shanghai University of Electric Power
2024-2025
University of Wisconsin–Madison
2023-2024
Soochow University
2024
Huzhou University
2021-2022
Panzhihua University
2022
Xuzhou University of Technology
2021
Dalian University of Technology
2019-2020
Nanjing University
2018-2020
Collaborative Innovation Center of Advanced Microstructures
2018
Central South University
1995-2016
NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX saponin-based adjuvant that induces antibody and T cell responses. We performed placebo-controlled clinical trial evaluating the safety immunogenicity of recombinant protein with adjuvant. Forty-six evaluable patients resected NY-ESO-1-positive tumors received three doses vaccine intramuscularly at monthly intervals. The was well tolerated. observed high-titer responses, strong delayed-type hypersensitivity...
Abstract Daytime radiative cooling is emerging as a passive and environmentally friendly strategy, compared to traditional methods that consume vast amount of energy with significant carbon footprint. To achieve the best performance, materials tailored for daytime need generate high emission in atmospheric transmission window (8–13 µm) radiating heat out directly universe simultaneously reflect entire solar radiation minimize thermal load. Recently, subambient has been demonstrated through...
Abstract Lithium dendrite growth during repeated charge and discharge cycles of lithium‐metal anodes often leads to short‐circuiting by puncturing the porous separator. Here, a morphological design, nano‐shield, for separators resist dendrites is presented. Through both mechanical analysis experiment, it revealed that separator protected nano‐shield can effectively inhibit penetration lithium owing reduced stress intensity generated therefore mitigate short circuit Li metal batteries. More...
Previous studies have shown that IL-10 may modulate immune responses towards the humoral arm by inhibiting production of cytokines involved in cell-mediated responses. In present studies, we found mRNA to could be demonstrated 66% melanoma cell lines PCR amplification reverse-transcribed and supernatants ELISA. Release into increased approximately 2-fold each day up 3 days. The MW 35S-labelled secreted cells was similar reported previous studies. also examined whether responsible for some...
Layered Na2FePO4F is utilized as a cathode in hybrid-ion batteries order to explore the ion migration and diffusion capability. It first time that mechanism capability battery investigated by considering activation energies of different ways. proposed rapid exchange Na+ ions on Na(2) site crystal structure with Li+ can take place produce NaLiFePO4F phase firstly confirmed principle calculations. conduction prone be two-dimensional (2D) interlayer plane an essentially restricted along [010]...
High-energy batteries need significant cathodes which can simultaneously provide large specific capacities and high discharge plateaus. NASICON-structured Na3V2(PO4)3 (NVP) has been utilised as a promising cathode to meet this requirement be used in the construction of energy batteries. For hybrid-ion battery by employing metallic lithium an anode, NVP exhibits initial capacity 170 mA h g(-1) voltage range 1.6-4.8 V with long plateau around 3.7 V. Three Na(2) sites for are found capable...
Under-oil open microfluidic system, utilizing liquid-liquid boundaries for confinements, offers inherent advantages including clogging-free flow channels, flexible access to samples, and adjustable gas permeation, making it well-suited studying multi-phase chemical reactions that are challenging closed microfluidics. However, reports on the novel system have primarily focused device fabrication functionality demonstrations within biology, leaving their application in broader analysis...
There is increasing evidence showing the involvement of CD4 + T cells in initiating and maintaining antitumor immune responses. NY-ESO-1 expressed by various tumors but not normal tissues except testis. We conducted a cancer clinical trial using full-length protein formulated with ISCOMATRIX adjuvant injected into patients intramuscularly. Autologous dendritic pulsed combination overlapping synthetic peptides were used to identify immunodominant from vaccinated patient. show here...
Abstract NY-ESO-1 is a 180 amino-acid human tumor antigen expressed by many different types and belongs to the family of “cancer-testis” antigens. In humans, one most immunogenic antigens peptides have been shown induce NY-ESO-1-specific CD8+ CTLs capable altering natural course NY-ESO-1-expressing tumors in cancer patients. Here we describe preclinical immunogenicity efficacy protein formulated with ISCOMATRIX adjuvant (NY-ESO-1 vaccine). vitro, vaccine was readily taken up monocyte-derived...
Epitope-based vaccination strategies designed to induce tumor-specific CD8 CTL are being widely considered for cancer immunotherapy. Here we describe a recombinant poxvirus vaccine that codes ten HLA-A2-restricted epitopes derived from five melanoma Ags conjoined in an artificial polyepitope or polytope construct. Target cells infected with the vaccinia were recognized by three different epitope-specific lines HLA-A2 patients, and responses seven of generated at least one six...
NY-ESO-1 is a germ cell antigen aberrantly expressed in different tumor types that elicits strong humoral and cellular immune responses cancer patients. Monitoring spontaneous CD8 + T against peptides 157–165 (S9C) 157–167 (S11L) series of HLA-A2 patients showed these two had overlapping antigenic profiles were equally immunogenic. However, discrepancies between S9C S11L reactivities observed upon vaccination with both to generate or boost We here analyze the fine specificity describe an...
Flt3 ligand mobilizes dendritic cells (DCs) into blood, allowing generation in vivo of large numbers DCs for immunotherapy. These immature can be rapidly activated by soluble CD40 (CD40L). We developed a novel overnight method using these cytokines to produce cancer ligand-mobilized (FLDCs) were isolated, with CD40L, loaded antigenic peptides from influenza matrix protein, hepatitis B core antigen, NY-ESO-1, MAGE-A4, and MAGE-A10, injected patients resected melanoma. Three injections given...
Carbon dioxide (CO2) mineralization based on aqueous carbonation of alkaline earth silicate minerals is a promising route toward large-scale carbon removal. Traditional methods largely adopt acidification-based approaches, e.g., using concentrated/pressurized CO2 or acidic media, to accelerate mineral dissolution and carbonation. In this study, we designed tested three distinctive routes evaluate the effect pretreatments under different pH conditions carbonation, amorphous calcium (CS) as an...
This study investigates the differential capacity of TAP-deficient T2 cells, TAP-competent EBV and immature mature dendritic cells to present peptides preformed CTL lines. It demonstrates that presentation exogenous involves peptide uptake loading onto newly synthesized MHC class I molecules. mechanism was best demonstrated for low affinity in presence irrelevant competing HLA binding sites. Under these circumstances, inhibition protein synthesis with cycloheximide or vesicular trafficking...
A novel silica-supported 2-aminomethyl pyridine adsorbent was synthesized using a post-grafting route. This synthetic route involved the reaction of (AMP) with γ-chloropropyltrimethoxysilane (CPTS) prior to immobilization on silica support. Based extensive evidences that amines and acids can play an important role in silanization as activator, meglumine mixture hydrochloric acid ethanol were utilized gentle but effective catalyst. Accordingly, three different pathways investigated catalysis...
3D hollow reduced graphene oxide foam as host for prestring lithium high capacity metal anode.
The aqueous carbonation of calcium silicate (CS), a representative alkaline-earth silicate, has been widely explored in studies carbon dioxide (CO