A5015142085- Advanced Chemical Sensor Technologies
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Glycosylation and Glycoproteins Research
- Malaria Research and Control
- Olfactory and Sensory Function Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infant Nutrition and Health
- Chemical Synthesis and Analysis
- Biochemical Analysis and Sensing Techniques
- High Altitude and Hypoxia
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Neurobiology and Insect Physiology Research
- Plant biochemistry and biosynthesis
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Asthma and respiratory diseases
- Click Chemistry and Applications
- Meat and Animal Product Quality
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Vector-borne infectious diseases
- Metabolomics and Mass Spectrometry Studies
Owlstone Medical (United Kingdom)
2021-2024
Washington University in St. Louis
2016-2019
St. Louis Children's Hospital
2018
Yale University
2015
Discovery Laboratories (United States)
2004
ABSTRACT The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe chemical profile of cultured parasites. Among identified compounds are several terpenes and terpene derivatives, including mosquito attractants. We establish molecular identity odorant receptors vector Anopheles...
Abstract Severe malaria due to Plasmodium falciparum infection remains a serious threat health worldwide and new therapeutic targets are highly desirable. Small molecule inhibitors of prenyl transferases, enzymes that catalyze the post-translational isoprenyl modifications proteins, exhibit potent antimalarial activity. The actions prenyltransferase indicate protein prenylation is required for parasite development. In this study, we used chemical biology strategy experimentally characterize...
Current evidence suggests that malarial infection could alter metabolites in the breath of patients, a phenomenon be exploited to create breath-based diagnostic test. However, no study has explored this clinical setting. To investigate whether natural human leads characteristic profile, we performed field Malawi. Breath volatiles from children with and those without uncomplicated falciparum malaria were analyzed by thermal desorption–gas chromatography/mass spectrometry. Using an unbiased,...
Exhaustive exercise can induce unique physiological responses in the lungs and other parts of human body. The volatile organic compounds (VOCs) exhaled breath are ideal for studying effects exhaustive on due to proximity matrix respiratory tract. As VOCs originate from bloodstream, changes abundance should also indicate broader Currently, there is limited published data VOCs. Breath has great potential biomarker analysis as it be collected non-invasively, capture real-time metabolic better...
In this report, we present a <italic>post hoc</italic> analysis from two observational cohorts, comparing the global breath volatile profile captured when using polymer sampling bags (mixed breath) <italic>versus</italic> Bio-VOC™ (alveolar breath).
Lung inflammation releases volatile organic compounds (VOCs) and occurs in several illnesses, as a response to pollution other irritants. VOCs breath could be tool non-invasively detect monitor inflammation. Breath (via Biopsy) is used such discover biomarkers of exposure, metabolism, disease. We investigated exhaled associated with lung induced by an allergen challenge, the hypothesis being that exposure mild induces epithelial tissue this will result production specific breath. Eleven...
<b>Background:</b> Exhaustive exercise can cause lung damage and other physiological responses in the human body. Volatile organic compounds (VOCs) be exchanged alveoli between breath circulated blood, making them ideal non-invasive biomarkers to understand effects of exhaustive on lungs parts Only a limited number studies have used VOCs exercise. To date, no explored VOC changes context running an ultramarathon, which takes roughly 40 hours complete. <b>Methods:</b> identify potential...
PURPOSE: To date, limited studies have examined exhaled VOC profiles in response to a physiologic stressor such as ultra-endurance exercise. Accordingly, this study evaluated production breath and the relationship respiratory function running an ultramarathon. METHODS: Breath samples (VOC Biopsy, Owlstone Medical, Cambridge UK) were collected from 29 runners before after participating either 2019 Ultra-Trail du Mont-Blanc (171 km) or Courmayeur-Champex-Chamonix (100 Additionally, subjects...