A5010940230- Cervical Cancer and HPV Research
- Reproductive tract infections research
- Gut microbiota and health
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- Urinary and Genital Oncology Studies
- Colorectal and Anal Carcinomas
- Urological Disorders and Treatments
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Preterm Birth and Chorioamnionitis
Radboud University Nijmegen
2016-2022
Radboud University Medical Center
2016-2022
Radboud Institute for Molecular Life Sciences
2019-2021
University Medical Center
2020
Catharina Ziekenhuis
2020
Nova Scotia Health Authority
2016
Queen Elizabeth II Health Sciences Centre
2016
Objective The purpose of this study was to review the management and outcome cervical intraepithelial neoplasia 2 (CIN2) in women younger than 25 years. Methods A retrospective performed, investigating years at time diagnosis with biopsy-proven CIN2 between January 1, 2010, December 31, 2014, who were seen colposcopy clinic Queen Elizabeth II Hospital Halifax, Nova Scotia, Canada. regression, persistence, progression rate conservative managed evaluated, potential risk factors examined....
Background Excisional procedures of cervical intraepithelial neoplasia (CIN) may increase the risk preterm birth. It is unknown whether this increased due to excision procedure itself, underlying CIN, or secondary factors that are associated with both birth and CIN. The aim study assess spontaneous in women treated untreated CIN examine possible associations by making a distinction between excised volume tissue having disease. Methods findings This Dutch population-based observational cohort...
BackgroundIn 2017, the Dutch cervical cancer screening program had replaced primary cytology-based with high-risk human papillomavirus-based screening, including opportunity to participate through self-sampling. Evaluation and balancing benefit (detection of high-grade intraepithelial neoplasia) burden (unnecessary referrals, invasive diagnostics, overtreatment) is needed.ObjectiveThis study aimed compare referral rates, detection neoplasia, overdiagnosis, overtreatment in new program,...
Hormonal contraceptive use has been associated with the development of cervical cancer, although inconsistent results are reported on association intrauterine device (IUD) use. The aim this study was to evaluate between type and intraepithelial neoplasia grade III or worse (CIN3+).A retrospective population-based cohort including women aged 29-44 years attending cancer screening program normal cytology 2005 2009 identified from Dutch Pathology Registry. Subgroups at least 5 registered an...
ObjectiveTo estimate the risk of cervical cancer in women with a history intraepithelial neoplasia (CIN) grade 3 and to review compliance post-treatment follow-up.MethodsA population-based retrospective cohort study including 80,442 median follow-up 15.8 years, 1,278,297 person years. Women CIN3 between 1990 2010 were identified from Dutch Pathology Registry (PALGA) linked general female population Netherlands Cancer Registry. Cases recurrent cancer, defined as occurrence minimally two years...
Abstract Background The cervicovaginal microbiome (CVM) plays a significant role in women’s cervical health and disease. Microbial alterations at the species level characteristic community state types (CST) have been associated with acquisition persistence of high-risk human papillomavirus (hrHPV) infections that may result progression lesions to malignancy. Current sequencing methods, especially most commonly used multiplex 16S rRNA gene sequencing, struggle fully clarify these changes...
Abstract Background Because most cervical cancers are caused by high-risk human papillomaviruses (hrHPVs), cancer prevention programs increasingly employ hrHPV testing as a primary test. The high sensitivity of HPV tests is accompanied low specificity, resulting in rates overdiagnosis and overtreatment. Targeted circular probe-based RNA next generation sequencing (ciRNAseq) allows for the quantitative detection RNAs interest with depth. Here, we examined potential ciRNAseq-testing on scrapes...
Only a few small studies have compared the 2-step method (biopsy followed by treatment) with see-and-treat (immediate approach in women both low-grade or high-grade referral cytology. The clinical practice variation Netherlands has not been reviewed before.To determine overtreatment rates versus referred for colposcopy because of abnormal cytology results, and to evaluate Netherlands.This was population-based retrospective cohort study including 36,581 histologic result cervix identified...
Women with cervical intraepithelial neoplasia grade 3 (CIN3) have a long‐lasting increased risk for noncervical high‐risk human papillomavirus (hrHPV)‐related (pre)malignancies. The aim of our study was to estimate this in women recurrent CIN3 compared without history and single episode CIN3. diagnosis between 1990 2010 were obtained from the Dutch Pathology Registry (PALGA) matched control group Analysis has been conducted subset CIN3, defined as reoccurrence minimally 2 years...
Cytology performed directly on hrHPV-positive self-samples (reflex cytology) is feasible and for women with abnormal cytology, an additional cytology test at the general practitioner could be omitted. The aim of this study to assess added value digital imaging (ThinPrep® Imaging System) clinical utility reflex by reducing screening error.A secondary analysis a prospective cohort study.One five Dutch laboratories.Women tested between December 2018 August 2019.Self-samples were used without...
(Abstracted from Gynecol Oncol 2020;157:195–201) Cervical cancer screening programs and prophylactic high-risk human papillomavirus have significantly decreased the incidence increased early detection of cervical intraepithelial neoplasia (CIN), which can progress to if left untreated. Surgical excision CIN is very effective; however, research shows that women who previously treated are at an risk for developing compared with general population.
Dear editor/Sir,We thank Song et al. for their insightful comments (1) on our article (2) and commend them study about human papillomavirus (HPV)-genotyping self-samples analysis different triage strategies detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) (3). They report that cytology physician-sampled material has a sensitivity of 74.8% CIN2+, while HPV-genotyping 16/18 52.6% CIN2+. This means in hands, is still inferior to testing cannot fully replace this strategy....