Efficient drug delivery remains a critical challenge for treating neurodegenerative diseases, such as Alzheimer’s disease (AD). Using innovative nanomaterials, delivering current medications like acetylcholinesterase inhibitors to the brain through intranasal route is promising strategy managing AD. Here, we developed unique combinational system based on N,N,N-trimethyl chitosan nanoparticles (NPs). These NPs encapsulate rivastigmine, most potent inhibitor, along with insulin, complementary...

Intranasal administration is a drug delivery approach to provide non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve residence time of intranasal systems nasal mucosa, mucoadhesive polymers (e.g., chitosan) can be used. Here, insulin-loaded chitosan nanoparticles were synthesized and their physiochemical properties evaluated based on requirements administration. The spherical (a hydrodynamic diameter 165.3 nm,...

Objectives: The aim of this study was to evaluate neurobehavioral toxicity single-walled (SWNTs) and multiwalled carbon nanotubes (MWNTs) in mice. Methods: Male NMRI mice were randomized into 5 groups ( n = 10 each): Normal control (NC) group injected intraperitoneally (i.p.) with phosphate-buffered saline (PBS) solution (pH 7.8; ca. 1 mL), MW80 MW800 either i.p. 80 or 800 mg kg −1 MWNTs suspended mL PBS SW80 SW800 SWNTs PBS. After 2 weeks, five from each evaluated for brain-derived...

Xanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, in silico target fishing of novel xanthone derivatives. The products reactions xanthydrol with urea, thiourea, thiosemicarbazide reacted α-haloketones to prepare thiazolone compounds. Xanthydrol sequentially ethyl chloroacetate, hydrazine, carbon disulfide, dithiolane. propargyl bromide it submitted click reaction azide triazole ring. Finally,...

The essential oils (EO) of Salix aegyptiaca L., Salicaceae (SA), leaves were extracted using the hydrodistillation method and their chemical composition was further determined by GC-MS. 1,4-Dimethoxybenzene main isolated compound. Other major constitutes phenylethyl alcohol, carvone, citronellol, methyleugenol, eugenol, n-tetradecane 4'-methoxyacetophenone. Twenty rabbits equally divided into four groups: Normal control (NC) which fed a standard diet three cholesterol-fed HC, HC+1.0% SA...

Multiwalled carbon nanotubes (MWCNTs) with unique chemical and electromechanical properties are ideal candidates for the development of drug delivery platforms. The scarce knowledge effects exposure to MWCNTs during pregnancy on postnatal outcomes motivated us investigate whether intraperitoneal injections (i.p.) mating early affect reproductive neurobehavioral endpoints psychobiological status pups. Thirty virgin female mice were divided three groups (n = 10 each); two treated injected i.p....

Abstract Aim The main goal of this study was to compare developmental competence and oxidative status vitrified‐warmed pre‐antral follicles ( VPF ) with derived from ovarian tissue VOF in the presence alpha lipoic acid ALA ). Materials Methods Ovarian isolated were exposed equilibration solution then vitrification solution. After thawing LN2 snap‐frozen samples, cultured or without for 12 days that followed by hCG ‐induced ovulation. MII oocytes vitro fertilized embryo cleavage assessed....

Summary Astragalus verus Olivier, Fabaceae has been used against ringworm in Kurdish ethnomedicine throughout millennia. The objective of this study was to evaluate the effects A. extracts Trichophyton verrucosum on vitro and vivo guinea pig model dermatophytosis. skin albino pigs infected with T. (1.0 × 10 7 conidia) animals were divided into five groups ( n = 5 for each): negative control (NC), received a vehicle; positive (PC), topical terbinafine 1.0% three other groups: AE10%, AE20%...

Cannabis sativa L. is considered as nutritional plant. Whole hempseed typically contains over 30% oil (3%saturated and 28%unsaturated fatty acids) about 25% protein. This study was conducted to evaluate the effect of on lipid protein profiles rats. After acclimatization, at beginning experiment (day 1) feeding animal stopped after 12hr fasting anesthetized by ketamine/xylazine combination 2ml blood heart taken. The rats had free access normal diet for 20 days end 20) taken again. parameters...

Therapeutic potential of in vitro maturation (IVM) infertility is growing with great promise. Although significant progress obtained recent years, existing IVM protocols are far from favorable results. The first aim this study was to investigate whether two step manner change reactive oxygen species (ROS) and total anti- oxidant capacity (TAC) levels. second find the effect alpha lipoic acid (ALA) supplementation on oocyte rate ROS/TAC levels during IVM.In experimental study, mouse germinal...

Purpose: To investigate the antidermatophytic effects of Urtica dioica L. against Microsporum canis in vitro and a guinea pig model.Methods: The antifungal activity extracts was measured by disc diffusion method assessment minimum inhibitory concentration (MIC). dorsum pigs infected with M. topically treated as follows: negative control (NC) received no treatment; positive (PC) terbinafine 1 %; DMSO group (negative control) 10 % (vehicle); while three other groups, viz, SN10%, SN20% SN30%...

To determine the prevalence of Trichomonas vaginalis (Tv) among women that presented to hospitals in Kermanshah district Iran 2006 and 2007. Materials methods: This retrospective study included 33.690 primary pathology laboratories Kermanshah. Vaginal cervical swabs were collected, then stained with Papanicolaou (Pap) stain. Additionally, seasonal variations rate compared identify significant differences Tv according season. Results: Among 33,690 women, 300 infected (a 0.9%). The...