A5016842685- Salivary Gland Tumors Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Oral and Maxillofacial Pathology
- Proteoglycans and glycosaminoglycans research
- IgG4-Related and Inflammatory Diseases
- Radiation Dose and Imaging
- Oral Health Pathology and Treatment
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- Head and Neck Anomalies
- Oral and gingival health research
- Cancer Cells and Metastasis
- Ear and Head Tumors
- dental development and anomalies
- Glycosylation and Glycoproteins Research
- Effects of Radiation Exposure
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Biochemical Analysis and Sensing Techniques
- Barrier Structure and Function Studies
- Nuclear and radioactivity studies
- Caveolin-1 and cellular processes
- Radioactive contamination and transfer
- Radioactive element chemistry and processing
- Laser Applications in Dentistry and Medicine
King's College London
2010-2022
Royal Brisbane and Women's Hospital
1996-2022
University Hospitals Birmingham NHS Foundation Trust
2020
Manchester University NHS Foundation Trust
2020
University of Birmingham
2020
University of Surrey
2020
Aston University
2020
St Thomas' Hospital
2001-2017
St. Thomas Hospital
2016-2017
Public Health England
1987-2016
Aims: Confusion about the aetiology and pathogenesis of chronic submandibular sialadenitis led to present investigation 154 cases in which many clinical histological features were analysed. Methods results: By far greatest number factors, namely liths, atrophy, fibrosis, parenchymal inflammation, lymphoid germinal centres, mucous ciliary metaplasia, salivary extravasation glycosaminoglycan accumulation, was related degree appears be importance pathogenesis. Inflammation, atrophy fibrosis...
We conducted an updated epidemiological study of Leber hereditary optic neuropathy (LHON) in Australia by using registry data to establish the risk vision loss among different LHON mutations, sex, age at onset, and mitochondrial haplogroup. identified 96 genetically unrelated pedigrees, including 56 unpublished 40 previously known comprising 620 affected individuals 4,948 asymptomatic carriers. The minimum prevalence due 2020 was one 68,403 individuals. Although our confirm some...
Forty-two submandibular, 32 sublingual and 31 parotid glands have been examined microscopically after ductal ligation avoiding the nerves for periods from 1 day to yr. After an initial increase in size, there was over-all atrophy all three glands. In gland response uniform progressive until most of acini were extremely atrophic. However, submandibular very variable, although some atrophic, other far less remaining appeared more or similar normal despite prolonged ligation. These results...
An odontogenic myxoma of a maxilla has been examined. Histochemistry the mucosubstance indicated that hyaluronic acid and chondroitin sulphate were present. On ultrastructural examination many cells in myxomatous tissue seen with prominent rough endoplasmic reticulum, suggesting secretory function, possibly ground substance was produced by these cells. Cells containing collagen fibrils found. Epithelial islands intercellular spaces producing an arrangement similar to stellate reticulum...
Weiler C, Zengel P, van der Wal J E, Guntinas-Lichius O, Schwarz S, Harrison D, Kirchner T & Ihrler S(2011) Histopathology59, 741–750 Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation 41 cases Aims: To investigate large series carcinoma (CEPA) determine factors. Methods and results: Thirty CEPA associated primary (PA) 11 recurrent PA were investigated. The median follow-up was 57.7 months,...
Aims : Although intraductal carcinoma has been demonstrated in intracapsular ex pleomorphic adenoma (CEPA), the morphological and genetic stages of transformation (PA) to CEPA are not fully understood. The aim this study was investigate morphology CEPA. Methods results largest series studied subject immunohistochemical double‐staining detect p53 protein cellular proliferation different types cell combined with mutational analysis gene laser‐microdissected material. Intraductal high‐grade...
Pedigree analysis showed that a large proportion of Leber hereditary optic neuropathy (LHON) family members who carry mitochondrial risk variant never lose vision. Mitochondrial haplotype appears to be major factor influencing the vision loss from LHON. variants, including m.14484T>C and m.11778G>A, have been added gene arrays, thus many patients research participants are tested for LHON mutations. Analysis UK Biobank Australian cohort studies found more than 1 in 1,000 people general...
An unusual giant-cell granulomatous inflammatory oral lesion is characterised by the presence of hyaline rings and a lack agreement on their nature, opinions ranging from being degenerative blood-vessels to remains leguminous cells. Ten such lesions variety vegetables have been examined in present investigation. Light-microscopical examination revealed surrounded inflamed granulation tissue with associated multinuclear giant Electron-microscopical showed them consist material similar that...
A search for microcalculi was made in 14 cases of chronic submandibular sialadenitis. Microcalculi were found all cases. They within serous acinar cells and ductal cells, lumina, interstitially. stained variably by periodic-acid/Schiff Alcian Blue at pH 2.5. Ultrastructural analytical examination showed them to consist crystals containing calcium phosphorus. The observations support the possibility that form autophagosomes, enter lumina occasionally become impacted produce sialolithiasis
A common tattoo occurring in the mouth is caused by insertion of amalgam filling material into soft tissues. Fifteen tattoos were examined. Amalgam or its derivatives found within macrophages, fibroblasts and multinuclear giant cells. Fine particles associated with: basement-membranes mucosal epithelium, striped muscle fibres, cells blood vessels; collagen; elastic tissue; connective tissue nerves. consists mainly mercury, silver tin. The analytical results suggest that corrosion occurs...
The mylohyoid hiatus and hernia were discovered in the nineteenth century considered to explain origin of plunging ranula from sublingual gland. This formed rationale for sialadenectomy treatment ranula. However, a more recent, extensive histological investigation reported that hernias contained submandibular gland, which supported an gland We therefore decided investigate occurrence location nature hernia. Twenty‐three adult cadavers dissected region. locations dimensions hiatuses measured...
BACKGROUND AND OBJECTIVES Familial hyperparathyroidism may occur as familial isolated (FIHP) or part of an inherited syndrome, in particular multiple endocrine neoplasia types 1 and 2 A (MEN1, MEN2A) hyperparathyroidism–jaw tumour (HPT–JT) syndrome. The localization the genes responsible for these syndromes has enabled genetic screening families with primary (PHPT) to be carried out. This important clinical implications terms individual follow‐up management. We previously reported a large...
(1988). Radiation Dose to Patients from Radiopharmaceuticals. International Journal of Biology: Vol. 54, No. 6, pp. 1059-1059.