A5052249323- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Maternal Mental Health During Pregnancy and Postpartum
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Renal Transplantation Outcomes and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Extracellular vesicles in disease
- Travel-related health issues
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Hepatitis Viruses Studies and Epidemiology
- Pregnancy and preeclampsia studies
- Diabetes and associated disorders
Hospital Clínico Universitario de Valencia
2022-2025
INCLIVA Health Research Institute
2021-2025
Vall d'Hebron Institut de Recerca
2024
Centro de Investigacion Principe Felipe
2024
Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The neurological functions affected remain unclear. aims were to: (1) Characterize the neuropsychological alterations in NAFLD patients; (2) assess prevalence of evaluated; (3) develop a new score for sensitive and rapid MCI detection NAFLD; (4) differences features between patients (NAFL) steatohepatitis (NASH); (5) compare cirrhotic MCI. Fifty-nine 53 controls performed psychometric tests...
Minimal hepatic encephalopathy (MHE) is common in cirrhosis, leading to cognitive impairment and eye-hand coordination (EHC) alterations. Hyperammonemia plays a key role MHE, contributing motor deficits. Elevated blood ammonia levels impaired EHC correlate with neuropsychiatric dysfunction, yet their direct impact on health-related quality of life (HRQoL) complex. This study examines the associations between ammonia, EHC, HRQoL, moderating influence sex these associations. Eighty-seven...
Neurofilament light chain protein (NfL) levels reflect neuronal damage in several neurological diseases and have been proposed as a possible biomarker. Plasma extracellular vesicles (EVs) could play an important role mediators of the inflammatory changes associated with inducing minimal hepatic encephalopathy (MHE) cirrhotic patients. This study investigated association NfL plasma EVs presence MHE patients, responses to rifaximin treatment. The were assessed 71 patients liver cirrhosis (40...
Abstract Patients with cirrhosis may show minimal hepatic encephalopathy (MHE), for which rifaximin is effective. Metabolic syndrome be associated cognitive impairment. Our aims were to evaluate the influence of metabolic features on response neurological and inflammatory alterations in MHE. A prospective cohort study was conducted 63 cirrhotic patients 30 controls from two tertiary centres recruited between 2015 2019. defined according Adult Treatment Panel-III. classified into 31 without...
Abstract Background Rifaximin is a non-reabsorbable antibiotic which acts at gut level, and improves cognition inflammatory parameters in minimal hepatic encephalopathy (MHE) patients, but not all patients show the same level of response. This study aims to assess brain activity, both within between networks, following rifaximin treatment, considering differences response groups as well. Methods Twenty-two healthy controls 53 with cirrhosis (22 without 31 MHE, diagnosed by Psychometric...
Minimal hepatic encephalopathy (MHE) is associated with changes in the immune system including an increased pro-inflammatory environment and altered differentiation of CD4+ T lymphocytes. The mechanisms remain unknown. Changes extracellular vesicle (EV) cargo proteins miRNAs could play a main role as mediators MHE. aim was to assess whether plasma EVs from MHE patients played inducing lymphocyte subtypes patients. We characterized miRNA protein 50 cirrhotic (27 without 23 MHE) 24 controls....
Abstract Minimal hepatic encephalopathy (MHE) is diagnosed using PHES battery, but other tests are more sensitive, and a simple tool for early MHE detection required. Assessment of saccadic eye movements useful cognitive alterations in different pathologies. We characterized the patients, its relationship with utility diagnosis. One-hundred eighteen cirrhotic patients (86 without 32 MHE) 35 controls performed Stroop test an battery by OSCANN system: visual saccades, antisaccades,...
Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The mechanisms involved remain unclear. plasma concentrations of several cytokines and chemokines were measured in 71 NAFLD patients (20 51 without MCI) 61 controls. Characterization activation leukocyte populations CD4+ sub-populations carried out analyzed by flow cytometry. We the released from cell cultures mRNA expression transcription factors receptors peripheral blood mononuclear cells....
Abundant evidence supports the significant impact of biological sex on various aspects Parkinson Disease (PD), including incidence, progression, symptoms or response to treatment. The incidence and prevalence disease is higher in males, while its age onset earlier than females. There are also differences symptomatology, both motor non-motor. In female PD, tremor, pain, depression dysphagia predominant, whereas male freezing gait, camptocormia, cognitive impairment urinary dysfunction more...
Background and Aims: Minimal hepatic encephalopathy (MHE) is associated with changes in the immune system including an increased pro-inflammatory environment altered differentiation of CD4+ T lymphocytes. The mechanisms remain unknown. Changes extracellular vesicle (EVs) cargo proteins miRNAs could play a main role as mediators MHE. aim was to assess whether plasma EVs from MHE patients inducing lymphocyte subtypes patients. Method: We characterized miRNA protein EV 50 cirrhotic (27 without...