To improve the efficiency of topical ocular drug administration, we focused on development a nanoparticles loaded contact lens to deliver hydrophobic over prolonged period time. The cross-linked based PCL (poly ε-caprolactone), 2-hydroxy ethyl methacrylate (HEMA), and poly ethylene glycol diacrylate (PEG-DA) were prepared by surfactant-free miniemulsion polymerization. material was through photopolymerization HEMA N-vinylpyrrolidone (NVP) using PEG-DA as cross-linker. Effects loading...

Lung diseases such as acute respiratory distress syndrome (ARDS) have a high incidence worldwide. The current drug therapies for ARDS supportive effects, making them inefficient. New methods stromal cell therapy are needed this problem. This research was performed with ten Zealand rabbits in two groups. Bone marrow aspiration on the treated group, and mesenchymal stem cells were isolated cultured. experimental model of induced using LPS from Escherichia coli strain O55:B5. Then, 1010 bone...

Background: Exogenous surfactants from natural sources help restore normal lung function in premature cases. Pulmonary-surfactant dysfunction can lead to acute injury and is characterized by alveolar instability, floating, collapse. These abnormalities occur adult respiratory distress syndrome (ARDS) neonatal (NRDS). Objectives: This study aimed identify the best source of exogenous surfactant its composition. Methods: Twenty-four healthy Holstein calves were selected three age groups both...

Abstract Background During transportation many horses develop post‐transportation infection, which can be life‐threatening and end their sport career. Preventing mucus accumulation inflammation during is vital, emphasizing the need for effective strategies to enhance overall horse health welfare. Objectives Assess impact of N‐acetylcysteine (NAC) on in subjected 18 hours head confinement. Animals Six healthy crossbred horses, 5.3 ± 2.1 years age weighing 387 30 kg. Methods Prospective...

Efficient production of functional and mature alveolar epithelial is a major challenge for developing any cell replacement therapy lung degenerative diseases. The extracellular matrix (ECM) pro-vides dynamic environment mediates cellular responses during development maintenance tissue functions. decellularized ECM (dECM) which retains its native-like structure bio-chemical composition can provide the induction embryonic stem (ESC) differentiation toward tissue-specific lineages in vitro...

Among the large animals, heart of sheep is functionally and structurally very similar to human heart. In research, are used as an animal model study process cardiac disease pathogenesis treatment. Therefore, determining normal values structures with echocardiography particular emphasis. The purpose present research define in Iranian Shall breed sheep.

Lipoma is a benign tumor of well-differentiated adipocytes that has been reported in some domestic animals. Omental lipomas human and animals are rare as case report. This study aimed to report an omental lipoma slaughtered sheep. In the observational examination sheep slaughterhouse Tehran Province, Iran, during inspection abdominal area, mass was seen on greater omentum. The sampled placed 10% formalin for histopathology. single, soft, dense, capsuled, oval, weighing 150 g, 4.5×3.5 cm...

Sheep have been used as translational models of human postnatal testicular development. However, the morphometric features normal developing testis in sheep embryos not previously investigated using stereology. The objective present work was to establish quantitative parameters for fetal tissue components sheep, unbiased design-based stereological methods. Twenty-four were divided into four gestational age groups (9-11, 12-14, 15-17 and 18-20 weeks gestation) on basis embryos' crown-rump...

Coenurosis and Listerial encephalitis are two diseases of the central nervous system in sheep. In September 2018, an 18-month-old male sheep was referred to Tehran University Veterinary Hospital with complaints dullness, depression anorexia. observation clinical examination within 1 hour, signs depression, body temperature 39°C , unilateral left sided blindness, clonic seizure, head deviation left, stiffness limbs, circling a circular path tilt were recorded. After examination, patient...

The introduction of an experimental animal model for myocardial infarction (MI) has particular importance. Research done on large animals provides valuable information the researchers because similar characteristics their hearts compared to humans, but cost purchasing and maintaining them is high. In comparison, using small advantages, such as they are easy work with have low purchase maintenance costs. However, in some these animals, due less similarity heart cannot simulate natural...

Abstract Methods: 10 healthy sheep were separated as the control (PBS) and treatment(BM-MSCs). The BM-samples aspirated in treatment group isolation expansion of BM-MSCs achieved. 24h after ARDS-induction by E.coli LPS (400 µg/kg), 5×10 7 1 ml PBS intrapulmonary infused groups, respectively. total lung volume Hounsfield unit CT-scan cardiac parameters echocardiography calculated before ARDS (time -24) cells/PBS infusion time(time 0) then for 6,12,24,48,72,168h infusion. At end, sacrificed...

Abstract Efficient production of alveolar epithelial cells and achieving optimal functionality maturity has presented a serious challenge in recent years. The extracellular matrix (ECM) provides dynamic environment mediates cellular responses during both development tissue repair. Decellularized ECM (dECM) which retains its native-like structure biochemical composition the signals needed to induce differentiation into tissue-specific lineages vitro. Here, we repopulated lung ECM-derived...