A5022193169- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- CRISPR and Genetic Engineering
- Neurobiology and Insect Physiology Research
- Single-cell and spatial transcriptomics
University of Illinois Chicago
2019-2020
Article19 August 2020Open Access Source DataTransparent process A cell atlas of adult muscle precursors uncovers early events in fibre-type divergence Drosophila Maria Paula Zappia Department Biochemistry and Molecular Genetics, University Illinois at Chicago, IL, USA Search for more papers by this author Lucia de Castro Majd M Ariss orcid.org/0000-0001-8013-5172 Holly Jefferson orcid.org/0000-0002-7989-2317 Abul BMMK Islam orcid.org/0000-0002-7274-0855 Genetic Engineering Biotechnology,...
Summary In Drosophila , the wing disc-associated adult muscle precursors (AMPs) give rise to fibrillar indirect flight muscles (IFM) and tubular direct (DFM). To understand early transcriptional events underlying this diversification, we performed single cell RNA-sequencing experiments built a atlas of AMPs associated with third instar larval disc. Our analysis identified distinct signatures for IFM DFM that underlie molecular basis their divergence. The further revealed various states...