A5042046224- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Sleep and related disorders
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Restless Legs Syndrome Research
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Nutritional Studies and Diet
- Bipolar Disorder and Treatment
- Biological Research and Disease Studies
- Mental Health and Psychiatry
- Sleep and Wakefulness Research
- Ginkgo biloba and Cashew Applications
- Diet and metabolism studies
- Personality Disorders and Psychopathology
- Alzheimer's disease research and treatments
National University of Singapore
2024-2025
National University Health System
2024
University of Hong Kong
2022-2024
King's College London
2019-2023
Chinese University of Hong Kong
2023
Queen Mary Hospital
2022
Objective: The underlying mechanisms of mild behavioral impairment (MBI), a marker for cognitive and dementia, have remained unclear especially in multiethnic Asian population. study aimed to examine whether baseline Alzheimer disease biomarkers, including plasma neurofilament light (NfL) chain, phosphorylated tau-181 (p-tau181), the p-tau181-to-amyloid-β42 (p-tau181/Aβ42) ratio, could predict MBI incidence dementia-free older adults. Methods: Participants were recruited from community...
Abstract Bidirectional relationship between sleep disturbances and affective disorders is increasingly recognised, but its underlying mechanisms are far from clear, there a scarcity of studies that report on in recurrent depressive disorder (RDD) bipolar (BPAD). To address this, we conducted retrospective study polysomnographic clinical records patients presenting to tertiary clinic with disorders. Sixty-three BPAD (32 female; mean age ± S.D.: 41.8 12.4 years) 126 age- gender-matched RDD (62...
Abstract Mentalizing, or theory of mind (ToM), impairments and self-referential hypermentalizing bias are well-evident in schizophrenia. However, findings compared to individuals with at-risk mental states (ARMS) inconsistent, investigations into the relationship between social cognitive anxiety two populations scarce. This study aimed examine compare these deficits first-episode schizophrenia-spectrum disorder (FES) ARMS, explore potential specific associations neurocognition...
Background Neurocognitive and neuropsychiatric symptoms are essential clinical manifestations of age-related cognitive impairment, yet their patterns co-existence remain unclear through the continuum. Objective To examine associations person-centered cluster-derived patterns, based on a comprehensive collection domain-specific assessments, with neuroimaging markers dementia risk. Methods 641 participants were included in analysis from memory clinics Singapore. Latent class was applied to...
Abstract Background Mild behavioural impairment (MBI) is associated with accelerated cognitive decline and conversion to dementia. However, the relationship between Alzheimer’s disease (AD)‐related pathological mechanisms MBI remains unclear. This study aimed examine whether baseline plasma neurofilament light chain (NfL), phosphorylated tau‐181 (P‐Tau181) P‐Tau181‐to‐Amyloid beta 42 (P‐Tau181/Aβ42) ratio are incident in an Asian cohort of dementia‐free individuals. Method Dementia‐free...
Abstract Brain serotonin dysregulation is associated with dementia and neuropsychiatric symptomology. However, the prognostic utility of circulating levels in detecting features prodromal including functional decline, cognitive impairment, mild behavioural impairment brain atrophy remains unclear. In this prospective study memory clinic subjects followed-up for ≤5 years, dementia-free subjects, classified as having no or at baseline, underwent annual neuropsychological assessments Montreal...