A5059750412- Circadian rhythm and melatonin
- Cancer survivorship and care
- Vestibular and auditory disorders
- Cancer-related cognitive impairment studies
- Sleep and Wakefulness Research
- Sleep and related disorders
- COVID-19 and healthcare impacts
- Spaceflight effects on biology
- Economic and Financial Impacts of Cancer
- Sleep and Work-Related Fatigue
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Trauma and Emergency Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and exercise physiology
- Ergonomics and Musculoskeletal Disorders
- Palliative Care and End-of-Life Issues
- Regulation of Appetite and Obesity
- Thermoregulation and physiological responses
- Ultrasound in Clinical Applications
- Sport Psychology and Performance
- Surgical site infection prevention
- Urban Green Space and Health
Normandie Université
2014-2025
Université de Caen Normandie
2014-2025
Inserm
2014-2025
Le Mans Université
2020-2024
Institut des Molécules et Matériaux du Mans
2021-2024
Cyceron
2020-2024
Laboratoire Motricité, Interactions, Performance
2023
Bellevue College
2023
Institut de Virologie
2020-2022
Massachusetts General Hospital
2021-2022
Hypergravity disrupts the circadian regulation of temperature (Temp) and locomotor activity (Act) mediated through vestibular otolithic system in mice. In contrast, we do not know whether anatomical structures associated with input are crucial for rhythm at 1 G on Earth. present study observed effects bilateral loss (BVL) daily rhythms Temp Act semipigmented rats. Our model lesion allowed selective peripheral hair cell degeneration without any other damage. Rats BVL exhibited a disruption...
Background New insights have expanded the influence of vestibular system to regulation circadian rhythmicity. Indeed, hypergravity or bilateral loss (BVL) in rodents causes a disruption their daily rhythmicity for several days. The thus influences hypothalamic rhythms on Earth, which raises question whether might be altered due pathology humans. aim this study was evaluate human people presenting total comparison with control participants. Methodology and Principal Findings Nine patients...
Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and/or treatment that persists for years after completion in approximately one third survivors. Exercise beneficial the management CRF, general exercise guidelines survivors are available. There multiple potential pathways by which improves with CRF diverse respect to type, treatments experienced side effects. While likely sufficient most survivors, tailoring interventions may be more effective those persistent...
Among factors impacting performance during an ultramarathon, sleep is underappreciated factor that has received little attention. The aims of this study were to characterize habitual behaviors in ultramarathon runners and examine strategies they use manage before ultramarathons. Responses from 636 participants a questionnaire considered. This population was found more on weekends holidays (7–8 h 8–9 h) than weekdays (6–7 7–8 h; p < 0.001). Work mediator napping habits since 19–25% reported...
Daytime activity is largely regulated by the day/night pattern. Various physiological and cognitive functions display a variation during diurnal period, where individuals manage their balance, spatial orientation consequently perception of vertical. However, findings concerning daytime changes postural control quality remain contradictory, mainly due to methodogical considerations. The aim our study evaluate effect time day on Fifteen male subjects underwent six test sessions over 24-hour...
The etiology of fatigability from whole body exercise was examined for the first time to accurately elucidate relationship between fatigue and in multiple sclerosis (MS). Compromised corticospinal responsiveness predicted severity, providing a novel, objective indicator MS. Although impaired corticomotor transmission did not aggravate muscle activation this group people with (PwMS) lower disability, heightened seen contribute perceptions PwMS.
Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued non-fatigued survivors. We hypothesized that would be more disturbed people experiencing clinically-relevant fatigue, objective measures associated with the severity Cancer survivors (n = 87) completed a 14-day wrist actigraphy measurement estimate their cycles. Fatigue measured using Functional Assessment Chronic Illness Therapy Scale...
The aim of the study was to test effect total sleep deprivation on performance and time-of-day pattern subjective visual vertical (SVV) postural control. Nineteen healthy, young participants (4 women 15 men 21.9 ± 1.2 yr) were engaged in two counterbalanced experimental sessions with or without deprivation. Oral temperature, Karolinska Sleepiness Scale, analogic scale for fatigue, control, SVV randomly measured every 4 h, from 0600 2200. A linear mixed model used capture time day condition...
Abstract Hypothalamic orexin neurons are involved in various physiological functions, including thermoregulation. The orexinergic system has been considered as a potent mediator of the exercise response. present study describes how antagonization by dual receptor antagonist (DORA) modifies thermoregulatory process during exercise. Core Body Temperature (CBT) and Spontaneous Locomotor Activity (SLA) 12 male Wistar rats were recorded after either oral administration DORA (30 mg/kg or 60 mg/kg)...
Background Patients with breast cancer (BC) exhibit circadian rhythm disruptions, mainly of rest-activity (RAR), which sleep is an essential component, and cortisol rhythm. Sleep complaints such as insomnia cognitive impairments are prevalent in BC. In general population, known to contribute greatly cognition. Thus, improving RAR (and particularly sleep) could help limiting BC patients. It has recently been suggested that, addition its role spatial memory, the vestibular system contributes...
Abstract Background Cancer-related fatigue (CRF) is the most common side effect of cancer and treatment. CRF prevalence up to 50% in breast patients can continue several years after remission. This persistent subjective sense exhaustion multifactorial. Numerous parameters have been evidenced be related across biological, physical, psychological, social and/or behavioral dimensions. Although has studied for many years, majority previous studies focused on only one dimension, i.e., physical...
Abstract Rest-activity rhythm (RAR) disruptions are frequently associated with chemotherapy in breast cancer (BC), but they less known BC endocrine therapy (ET). The aim of this ancillary study was to characterize the RAR and estimated sleep characteristics from actigraphy patients either treated (ET+) or untreated ET (ET−), compared healthy controls (HC) using a cross-sectional design. Eighteen ET+, 18 ET−, 16 HC completed questionnaires wore wrist actigraphs at home for 2 weeks. Parametric...
The vestibular system is responsible for sensing every angular and linear head acceleration, mainly during periods of motor activity. Previous animal human experiments have shown biological rhythm disruptions in small rodents exposed to a hypergravity environment, but also patients with bilateral loss compared control population. This raised the hypothesis afferent influence on circadian synchronization. present study aimed test impact stimulation induced by rotatory chair rest/activity...
Animal and human studies demonstrate anatomical functional links between the vestibular nuclei circadian timing system. This promotes hypothesis of a rhythm function. The objective this study was to evaluate function through vestibulo-ocular reflex using rotatory chair at different times day assess rhythmicity Two identical evaluating temporal variation (VOR) were performed, first in young adults (age: 22.4 ± 1.5 y), second older (70.7 4.7 y). slow phase velocity time constant VOR evaluated...
Many patients treated for breast cancer (BC) complain about cognitive difficulties affecting their daily lives. Recently, sleep disturbances and circadian rhythm disruptions have been brought to the fore as potential contributors in with BC. Yet, studies on these factors well neural correlates are scarce. The purpose of ICANSLEEP-1 (Impact SLEEP CANcer) study is characterize using polysomnography its relationship evolution functioning at both behavioral neuroanatomical levels across...
Abstract Purpose COVIDTrach is a UK multi-centre prospective cohort study project evaluating the outcomes of tracheostomy in patients with COVID-19 receiving mechanical ventilation. It also examines incidence SARS-CoV-2 infection among healthcare workers involved procedure. Method An invitation to participate was sent all NHS departments patients. Data entered prospectively and clinical updated via an online database (REDCap). Clinical variables were compared using multivariable regression...
Abstract Input from the light/dark (LD) cycle constitutes primary synchronizing stimulus for suprachiasmatic nucleus (SCN) circadian clock. However, SCN can also be synchronized by non-photic inputs. Here, we hypothesized that vestibular system, which detects head motion and orientation relative to gravity, may provide sensory inputs synchronize rhythmicity. We investigated resynchronization of core temperature (Tc) rhythm a six-hour phase advance LD (LD + 6) using hypergravity (2 G) as...