A5031666867- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Poxvirus research and outbreaks
- Fire effects on ecosystems
- Respiratory viral infections research
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Veterinary Equine Medical Research
- Virology and Viral Diseases
- Topological Materials and Phenomena
- Plant Virus Research Studies
- Reproductive Physiology in Livestock
- Heusler alloys: electronic and magnetic properties
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Magnetic and transport properties of perovskites and related materials
National Institute of Infectious Diseases
2016-2025
Okayama Red Cross General Hospital
2022-2025
Okayama University
2025
Nara Medical University
2023
Beckman Coulter Foundation
2023
Tohoku University
2022
Instituto Conmemorativo Gorgas de Estudios de la Salud
2021
Kagawa Prefectural Central Hospital
2021
Hiroshima University
2017-2021
Universidade Federal de Goiás
2021
Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient retrospective study on Japan.
Severe acute respiratory syndrome (SARS), which is caused by a novel coronavirus (CoV), highly communicable disease with the lungs as major pathological target. Although SARS likely stems from overexuberant host inflammatory responses, exact mechanism leading to detrimental outcome in patients remains unknown. Pulmonary macrophages (Mphi), airway epithelium, and dendritic cells (DC) are key cellular elements of innate defenses against infections. While pulmonary Mphi situated at luminal...
ABSTRACT Poliovirus selectively replicates in neurons the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed both target nontarget tissues humans transgenic mice expressing human PVR (PVR-transgenic mice). We assessed role of alpha/beta interferon (IFN) determining tissue tropism by comparing pathogenesis virulent Mahoney strain PVR-transgenic deficient IFN gene (PVR-transgenic/ Ifnar knockout PVR-transgenic/ showed increased susceptibility to poliovirus....
The role of secretory IgA in conferring cross-protective immunity was examined polymeric (p)IgR knockout (KO) mice immunized intranasally with different inactivated vaccines prepared from A/PR/8/34 (H1N1), A/Yamagata/120/86 A/Beijing/262/95 and B/Ibaraki/2/85 viruses infected the virus upper respiratory tract (RT)-restricting volume. In wild-type mice, immunization or its variant (A/Yamagata/120/86 A/Beijing/262/95) conferred complete protection partial cross-protection against infection,...
Human lung epithelial cells are likely among the first targets to encounter invading severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Not only can these support growth of SARS-CoV infection, but they also capable secreting inflammatory cytokines initiate and, eventually, aggravate host innate responses, causing detrimental immune-mediated pathology within lungs. Thus, a comprehensive evaluation complex signaling is crucial for paving way better understand SARS...
Background. Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne acute infectious disease caused by the SFTS virus (SFTSV). has been reported in China, South Korea, and Japan as novel Bunyavirus. Although several molecular epidemiology phylogenetic studies have performed, information obtained was limited, because analyses included no or only small number of SFTSV strains from Japan. Methods. The nucleotide sequences 75 samples were newly determined directly patients' serum...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is the causative agent of SFTS, an emerging hemorrhagic fever. This disease has a high case fatality rate and endemic to China, South Korea, Japan. Because there are currently no effective therapeutics for potent safe antivirals needed treatment SFTS. The inhibitory effect T-705 (favipiravir) on replication SFTSV in Vero cells was evaluated. Mice lacking type I interferon receptor (IFNAR(-/-)) were used as vivo lethal model infection....
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease a high case fatality risk and caused by the SFTS virus (SFTSV). A retrospective study conducted after first identification of patient in Japan revealed that endemic to region, exists indigenously Japan. Since nucleotide sequence Japanese SFTSV strains contains considerable differences compared Chinese strains, there urgent need establish sensitive specific method capable detecting SFTSV....
Canine distemper virus (CDV) has recently expanded its host range to nonhuman primates. A large CDV outbreak occurred in rhesus monkeys at a breeding farm Guangxi Province, China, 2006, followed by another an animal center Beijing 2008. In 2008 Japan, also cynomolgus imported from China. that outbreak, 46 died severe pneumonia during quarantine period. strain (CYN07-dV) was isolated Vero cells expressing dog signaling lymphocyte activation molecule (SLAM). Phylogenic analysis showed CYN07-dV...
We conducted an epidemiologic study of severe fever with thrombocytopenia syndrome (SFTS) in Japan during 2013-2017. Of 303 cases reported that period, 133 (44%) were included this study. The median time between onset illness and diagnosis SFTS shortened, from 11.5 to 3.0 days, but the case-fatality rate remained high, at 27%. In 64 patients (48%), a close contact companion animals was within 2 weeks disease onset. these patients, 40 surveyed further, we confirmed 3 had direct body fluids...
Atomically thin PtSe2 films have attracted extensive research interests for potential applications in high-speed electronics, spintronics and photodetectors. Obtaining high quality, single crystalline with large size is critical. Here we report the first successful layer-by-layer growth of quality by molecular beam epitaxy. from 1 ML to 22 been grown characterized low-energy electron diffraction, Raman spectroscopy X-ray photoemission spectroscopy. Moreover, a systematic thickness dependent...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic caused by the SFTS phlebovirus (SFTSV). patients were first reported in China, followed Japan and South Korea. In 2017, cats diagnosed for time, suggesting that these animals are susceptible to SFTSV. To confirm whether or not indeed SFTSV, animal subjects experimentally infected Four of six SPL010 strain SFTSV died, all showing similar more severe symptoms than human patients, such as a fever,...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic caused by a tick-borne banyangvirus and associated high fatality. Despite increasing incidence of SFTS serious public health concerns in East Asia, the pathogenesis lethal virus (SFTSV) infection humans not fully understood. Numbers postmortem examinations to determine target cells viral have so far been limited. Here we showed that B differentiating into plasmablasts macrophages secondary lymphoid organs were...
Abstract This study examined whether secretory IgA (S‐IgA) antibodies (Abs) could confer cross‐protective immunity against infection with influenza B viruses of antigenically distinct lineages. Wild‐type or polymeric Ig receptor (pIgR)‐knockout (KO) mice were immunized by different intranasal (i.n.) administration inactivated vaccines. Four weeks later challenged either the B/Ibaraki/2/85 virus, representative B/Victoria/2/87 (B/Victoria)‐lineage, B/Yamagata/16/88 B/Yamagata‐lineage. Three...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic a high case fatality rate caused by SFTS virus (SFTSV). Effective vaccines and specific therapies for are urgently sought, investigation into virus-host cell interactions expected to contribute the development of antiviral strategies. In this study, we have developed pseudotype vesicular stomatitis (VSV) bearing unmodified Gn/Gc glycoproteins (GPs) SFTSV (SFTSVpv). We analyzed host entry native SFTSV. Both SFTSVpv...
ABSTRACT A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as receptor only poorly but readily adapted to use it following P541S substitution the hemagglutinin protein. Since CYN07-dV had an intrinsic ability nectin-4, became able both immune and epithelial cell receptors, well monkey ones, suggesting that CDV can potentially infect humans.
Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) animal models. A multicenter non-randomized, uncontrolled single arm trial was conducted to collect data on the safety of favipiravir treatment patients. All participants received orally (first-day loading dose 1800 mg twice day followed by 800 for 7–14 days total). SFTSV RT-PCR biochemistry tests were performed at...
A woman in her fifties showed symptoms of fever, loss appetite, vomiting, and general fatigue 2 days after she was bitten by a sick cat, which had later died, Yamaguchi prefecture, western Japan, June 2016. She subsequently died multiorgan failure, an autopsy performed to determine the cause death. However, etiological pathogens were not quickly identified. The pathological features patient retrospectively re-examined, pathology regional lymph node at site cat bite found show necrotizing...
In the early phase after transmural myocardial infarction (MI), infarcted myocardium undergoes replacement by scar tissue, which is essential for preserving structural integrity of tissue. Transforming growth factor (TGF)-beta1, known as a fibrotic cytokine, plays pivotal role in reparative fibrosis MI. It reported that granulocyte colony-stimulating (G-CSF) can accelerate wound healing. The aim our study was to investigate effect G-CSF on ventricular expansion MI.MI induced ligation left...
Conventional Rashba spin polarization is caused by the combination of strong spin-orbit interaction and spatial inversion asymmetry. However, Rashba-Dresselhaus-type spin-split states are predicted in centrosymmetric LaOBiS2 system recent theory, which stem from local asymmetry active BiS2 layer. By performing high-resolution spin- angle-resolved photoemission spectroscopy, we have investigated electronic band structure texture superconductor LaO0.55F0.45BiS2. Here present direct...
Severe fever with thrombocytopenia syndrome (SFTS) is a disease high case fatality rate that caused by infection the recently identified tick-borne SFTS virus (SFTSV), for which there are no specific countermeasures. We examined effects of ribavirin and mizoribine, nucleoside analogue drugs broad antiviral activities, on SFTSV proliferation in vitro. When 3 cell lines were treated these before during Chinese strain, 99% effective concentrations (EC99) 19–64 μg/ml (78–262 μM); contrast, EC99...
We report on a 70-year-old man with fever, leukopenia, thrombocytopenia, vomiting, malaise, dyspnea, and consciousness disturbance who was infected severe fever thrombocytopenia syndrome virus in northern Taiwan, 2019. This autochthonous case confirmed by reverse transcription PCR, isolation, genomic sequencing.
Severe fever with thrombocytopenia syndrome (SFTS) caused by a species Dabie bandavirus (formerly SFTS virus [SFTSV]) is an emerging hemorrhagic infectious disease high case-fatality rate. One of the best strategies for preventing to develop vaccine, which expected induce both humoral and cellular immunity. We applied highly attenuated but still immunogenic vaccinia strain LC16m8 (m8) as recombinant vaccine SFTS. Recombinant m8s expressing SFTSV nucleoprotein (m8-N), envelope glycoprotein...